Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis by Long Ge, Gordon Guyatt, Bram Rochwerg, Thomas Piraino, Tim Karachi, Shannon M Fernando, Kimberley A Lewis, Dipayan Chaudhuri, Karen E A Burns, Karen Bosma, Nischal Ranganath, Laurent Brochard

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Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study by Jennifer L Y Tsang, David Armstrong, Kristen Sullivan, Roman Jaeschke, Tim Karachi, Cindy Hamielec, Joanna C Dionne, John W Devlin, Matthew Duprey, Rodrigo Cartin-Ceba, Mohammed Saeed Saad Alshahrani

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Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients (COMIC): a pilot randomised controlled trial protocol by Lehana Thabane, Wojciech Szczeklik, Bram Rochwerg, Kimberley Lewis, Sarah Culgin, Roman Jaeschke, Dan Perri, Corry Marchildon, Kelly Hassall, Thomas Piraino, Yousef Almubarak, Mohammed S Alshahrani, Bandar Baw, Tim Karachi, Waleed Alhazzani

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Tranexamic acid in cardiac surgery: a systematic review and meta-analysis (protocol) by Ryan Zarychanski, Bram Rochwerg, Tim Karachi, Alison Fox-Robichaud, Shannon M Fernando, Kwadwo Kyeremanteng, Thamer Alaifan, Ahmed Alenazy, Dominic Xiang Wang, Jessica Spence, Emilie Belley-Cote, Craig Ainswoth, Richard Whitlock

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Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial by Alyson Takaoka, Jennie Johnstone, François Lauzier, Diane Heels-Ansdell, Megan Davis, Nicole Zytaruk, Erick Duan, Joanna Dionne, Lois Saunders, Yaseen M. Arabi, John Marshall, Lehana Thabane, France Clarke, Lori Hand, Marie-Helene Masse, Bram Rochwerg, Lauralyn McIntyre, Martin Girard, Andreas Freitag, Tim Karachi, Deborah J. Cook, For The PROSPECT Investigators, The Canadian Critical Care Trials Group

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Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial by Devin S. McCaskell, Alexander J. Molloy, Laura Childerhose, F. Aileen Costigan, Julie C. Reid, Magda McCaughan, France Clarke, Deborah J. Cook, Jill C. Rudkowski, Christopher Farley, Tim Karachi, Bram Rochwerg, Anastasia Newman, Alison Fox-Robichaud, Margaret S. Herridge, Vincent Lo, Deanna Feltracco, Karen EA Burns, Rebecca Porteous, Andrew J. E. Seely, Ian M. Ball, Amy Seczek, Michelle E. Kho

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Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study by Daphnée Lamarche, Jennie Johnstone, Nicole Zytaruk, France Clarke, Lori Hand, Dessi Loukov, Jake C. Szamosi, Laura Rossi, Louis P. Schenck, Chris P. Verschoor, Ellen McDonald, Maureen O. Meade, John C. Marshall, Dawn M. E. Bowdish, Tim Karachi, Diane Heels-Ansdell, Deborah J. Cook, Michael G. Surette, for the PROSPECT Investigators, Canadian Critical Care Trials Group, Canadian Critical Care Translational Biology Group

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Correction to: Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial by Devin S. McCaskell, Alexander J. Molloy, Laura Childerhose, F. Aileen Costigan, Julie C. Reid, Magda McCaughan, France Clarke, Deborah J. Cook, Jill C. Rudkowski, Christopher Farley, Tim Karachi, Bram Rochwerg, Anastasia Newman, Alison Fox-Robichaud, Margaret S. Herridge, Vincent Lo, Deanna Feltracco, Karen E. A. Burns, Rebecca Porteous, Andrew J. E. Seely, Ian M. Ball, Amy Seczek, Michelle E. Kho

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Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength),... by Diane Heels-Ansdell, Laurel Kelly, Heather K O'Grady, Christopher Farley, Julie C Reid, Sue Berney, Amy M Pastva, Karen EA Burns, Frédérick D'Aragon, Margaret S Herridge, Andrew Seely, Jill Rudkowski, Bram Rochwerg, Alison Fox-Robichaud, Ian Ball, Francois Lamontagne, Erick H Duan, Jennifer Tsang, Patrick M Archambault, Avelino C Verceles, John Muscedere, Sangeeta Mehta, Shane W English, Tim Karachi, Karim Serri, Brenda Reeve, Lehana Thabane, Deborah Cook, Michelle E Kho

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Critical Care Cycling to Improve Lower Extremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ven... by Avelino C Verceles, Jennifer L Y Tsang, Sangeeta Mehta, Michelle E Kho, Alexander J Molloy, Margaret S Herridge, Bram Rochwerg, Ian M Ball, Joseph R Pellizzari, Jean-Eric Tarride, Diane Heels-Ansdell, John Muscedere, Francois Lamontagne, Tim Karachi, Alison Fox-Robichaud, Shane W English, Karen E A Burns, Frédérick D'Aragon, Sue Berney, Karim Serri, Erick H Duan, Lisa Buckingham, Julie Reid, Andrew J Seely, Christopher Farley, Amy M Pastva, Heather O'Grady, Laurel Kelly, Geoff Strong, Abby H Hurd

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