In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities by Clémentine Halliez, Clémentine Halliez, Hazem Ibrahim, Timo Otonkoski, Timo Otonkoski, Roberto Mallone, Roberto Mallone

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Generation of iPSC line HEL47.2 from healthy human adult fibroblasts by Ras Trokovic, Jere Weltner, Timo Otonkoski

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Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells by Ras Trokovic, Jere Weltner, Parinya Noisa, Taneli Raivio, Timo Otonkoski

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Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation by Diego Balboa, Jere Weltner, Solja Eurola, Ras Trokovic, Kirmo Wartiovaara, Timo Otonkoski

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Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9 by Diego Balboa, Jere Weltner, Yuval Novik, Solja Eurola, Kirmo Wartiovaara, Timo Otonkoski

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Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9 by Diego Balboa, Jere Weltner, Yuval Novik, Solja Eurola, Kirmo Wartiovaara, Timo Otonkoski

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Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function by Anja Brboric, Svitlana Vasylovska, Jonna Saarimäki-Vire, Daniel Espes, José Caballero-Corbalan, Gunnar Larfors, Timo Otonkoski, Joey Lau

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Differentiating functional human islet-like aggregates from pluripotent stem cells by Tom Barsby, Hazem Ibrahim, Väinö Lithovius, Hossam Montaser, Diego Balboa, Eliisa Vähäkangas, Vikash Chandra, Jonna Saarimäki-Vire, Timo Otonkoski

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A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation. by Sanna Vuoristo, Sanna Toivonen, Jere Weltner, Milla Mikkola, Jarkko Ustinov, Ras Trokovic, Jaan Palgi, Riikka Lund, Timo Tuuri, Timo Otonkoski

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Kaposi’s Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter by Endrit Elbasani, Francesca Falasco, Silvia Gramolelli, Veijo Nurminen, Thomas Günther, Jere Weltner, Diego Balboa, Adam Grundhoff, Timo Otonkoski, Päivi M. Ojala

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Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets by Tom Barsby, Eliisa Vähäkangas, Jarkko Ustinov, Hossam Montaser, Hazem Ibrahim, Väinö Lithovius, Emilia Kuuluvainen, Vikash Chandra, Jonna Saarimäki-Vire, Pekka Katajisto, Ville Hietakangas, Timo Otonkoski

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MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells by Maria Lindahl, Tatiana Danilova, Erik Palm, Päivi Lindholm, Vootele Võikar, Elina Hakonen, Jarkko Ustinov, Jaan-Olle Andressoo, Brandon K. Harvey, Timo Otonkoski, Jari Rossi, Mart Saarma

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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes by Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski

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Selective microRNA-Offset RNA expression in human embryonic stem cells. by Suvi Asikainen, Liisa Heikkinen, Juuso Juhila, Frida Holm, Jere Weltner, Ras Trokovic, Milla Mikkola, Sanna Toivonen, Diego Balboa, Riina Lampela, Katherine Icay, Timo Tuuri, Timo Otonkoski, Garry Wong, Outi Hovatta

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ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons by Sandra Harjuhaahto, Tiina S. Rasila, Svetlana M. Molchanova, Rosa Woldegebriel, Jouni Kvist, Svetlana Konovalova, Markus T. Sainio, Jana Pennonen, Rubén Torregrosa-Muñumer, Hazem Ibrahim, Timo Otonkoski, Tomi Taira, Emil Ylikallio, Henna Tyynismaa

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A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells. by Kristiina Rajala, Bettina Lindroos, Samer M Hussein, Riikka S Lappalainen, Mari Pekkanen-Mattila, Jose Inzunza, Björn Rozell, Susanna Miettinen, Susanna Narkilahti, Erja Kerkelä, Katriina Aalto-Setälä, Timo Otonkoski, Riitta Suuronen, Outi Hovatta, Heli Skottman

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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α by Vikash Chandra, Hazem Ibrahim, Clémentine Halliez, Rashmi B. Prasad, Federica Vecchio, Om Prakash Dwivedi, Jouni Kvist, Diego Balboa, Jonna Saarimäki-Vire, Hossam Montaser, Tom Barsby, Väinö Lithovius, Isabella Artner, Swetha Gopalakrishnan, Leif Groop, Roberto Mallone, Decio L. Eizirik, Timo Otonkoski

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Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential by Aija Kyttälä, Roksana Moraghebi, Cristina Valensisi, Johannes Kettunen, Colin Andrus, Kalyan Kumar Pasumarthy, Mahito Nakanishi, Ken Nishimura, Manami Ohtaka, Jere Weltner, Ben Van Handel, Olavi Parkkonen, Juha Sinisalo, Anu Jalanko, R. David Hawkins, Niels-Bjarne Woods, Timo Otonkoski, Ras Trokovic

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An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation by Jonna Saarimäki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski

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Comprehensive characterization of the embryonic factor LEUTX by Lisa Gawriyski, Eeva-Mari Jouhilahti, Masahito Yoshihara, Liangru Fei, Jere Weltner, Tomi T. Airenne, Ras Trokovic, Shruti Bhagat, Mari H. Tervaniemi, Yasuhiro Murakawa, Kari Salokas, Xiaonan Liu, Sini Miettinen, Thomas R. Bürglin, Biswajyoti Sahu, Timo Otonkoski, Mark S. Johnson, Shintaro Katayama, Markku Varjosalo, Juha Kere

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