Optimizing Precision Oncology and Immunotherapy Strategies: Moving into the Next Stage of Cancer Medicine by Phoebe Lewis, Timothy A Yap

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Future directions in the evaluation of c-MET-driven malignancies by Johann S. de Bono, Timothy A. Yap

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Immuno-oncology combinations: raising the tail of the survival curve by Samuel J. Harris, Jessica Brown, Juanita Lopez, Timothy A. Yap

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c-MET: an exciting new target for anticancer therapy by Johann S. de Bono, Timothy A. Yap BSc (Hons), MB BS, MRCP

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The Promise of Poly(ADP-Ribose) Polymerase (PARP) Inhibitors in Gliomas by Nazanin Majd, Timothy A. Yap, W. K. Alfred Yung, John de Groot

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Antibody-drug conjugates in lung cancer: dawn of a new era? by Niamh Coleman, Timothy A. Yap, John V. Heymach, Funda Meric-Bernstam, Xiuning Le

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Application of Real-World Data to External Control Groups in Oncology Clinical Trial Drug Development by Timothy A. Yap, Ira Jacobs, Elodie Baumfeld Andre, Lauren J. Lee, Darrin Beaupre, Laurent Azoulay, Laurent Azoulay

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Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition by Niamh Coleman, Vivek Subbiah, Shubham Pant, Keyur Patel, Sinchita Roy-Chowdhuri, Sireesha Yedururi, Amber Johnson, Timothy A. Yap, Jordi Rodon, Kenna Shaw, Funda Meric-Bernstam

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A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments. by Anna Minchom, Parames Thavasu, Zai Ahmad, Adam Stewart, Alexandros Georgiou, Mary E R O'Brien, Sanjay Popat, Jaishree Bhosle, Timothy A Yap, Johann de Bono, Udai Banerji

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IOLite: phase 1b trial of doublet/triplet combinations of dostarlimab with niraparib, carboplatin–paclitaxel, with or without bevacizumab in patients with advanced cancer by Wei Guo, Manish R Patel, Nashat Gabrail, Jordi Rodon, Erika Hamilton, Timothy A Yap, Meghan Duncan, Alberto Bessudo, Jasgit Sachdev, Lena Evilevitch, Sujatha Kumar, Sharon Lu, Bruce J Dezube

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Genomic profiling reveals high frequency of DNA repair genetic aberrations in gallbladder cancer by Reham Abdel-Wahab, Timothy A. Yap, Russell Madison, Shubham Pant, Matthew Cooke, Kai Wang, Haitao Zhao, Tanios Bekaii-Saab, Elif Karatas, Lawrence N. Kwong, Funda Meric-Bernstam, Mitesh Borad, Milind Javle

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Selinexor in combination with standard chemotherapy in patients with advanced or metastatic solid tumors by Kyaw Z. Thein, Sarina A. Piha-Paul, Apostolia Tsimberidou, Daniel D. Karp, Filip Janku, Siqing Fu, Vivek Subbiah, David S. Hong, Timothy A. Yap, Jatin Shah, Denái R. Milton, Lacey McQuinn, Jing Gong, Yanyan Tran, Brett W. Carter, Rivka Colen, Funda Meric-Bernstam, Aung Naing

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Limited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing by Carol J. Nowlen, Molly Daniels, Burak Uzunparmak, Ecaterina E. Ileana Dumbrava, Ying Yuan, Keyur P. Patel, Nadine Rayes, Jacqueline Harkenrider, Chetna Wathoo, Jennifer Veazie, Krystle A. Luna, Wanlin Wang, Chacha Horombe, Milind Javle, Jordi Rodon Ahnert, Timothy A. Yap, Banu Arun, Karen H. Lu, Funda Meric-Bernstam

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Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers. by Geraldine Perkins, Timothy A Yap, Lorna Pope, Amy M Cassidy, Juliet P Dukes, Ruth Riisnaes, Christophe Massard, Philippe A Cassier, Susana Miranda, Jeremy Clark, Katie A Denholm, Khin Thway, David Gonzalez De Castro, Gerhardt Attard, L Rhoda Molife, Stan B Kaye, Udai Banerji, Johann S de Bono

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Actionability classification of variants of unknown significance correlates with functional effect by Amber Johnson, Patrick Kwok-Shing Ng, Michael Kahle, Julia Castillo, Bianca Amador, Yujia Wang, Jia Zeng, Vijaykumar Holla, Thuy Vu, Fei Su, Sun-Hee Kim, Tara Conway, Xianli Jiang, Ken Chen, Kenna R. Mills Shaw, Timothy A. Yap, Jordi Rodon, Gordon B. Mills, Funda Meric-Bernstam

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Phase I study of sapanisertib with carboplatin and paclitaxel in mTOR pathway altered solid malignancies by Omar Alhalabi, Roman Groisberg, Ralph Zinner, Andrew W. Hahn, Aung Naing, Shizhen Zhang, Apostolia M. Tsimberidou, Jordi Rodon, Siqing Fu, Timothy A. Yap, David S. Hong, Ming Sun, Yunfang Jiang, Shubham Pant, Amishi Y. Shah, Amado Zurita, Nizar M. Tannir, Raghunandan Vikram, Jason Roszik, Funda Meric-Bernstam, Vivek Subbiah

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Predictors of Oncologic Outcome in Patients Receiving Phase I Investigational Therapy for Recurrent or Metastatic Cervical Cancer by Ji Son, Heather Y. Lin, Siqing Fu, Amadeo B. Biter, Ecaterina E. Dumbrava, Daniel D. Karp, Aung Naing, Shubham Pant, Sarina A. Piha-Paul, Jordi Rodon, Vivek Subbiah, Apostolia M. Tsimberidou, Timothy A. Yap, Michael M. Frumovitz, Amir A. Jazaeri, Pedro T. Ramirez, Shannon N. Westin, Ying Yuan, Funda Meric-Bernstam, David S. Hong

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Challenges and opportunities associated with the MD Anderson IMPACT2 randomized study in precision oncology by Henry Hiep Vo, Siqing Fu, David S. Hong, Daniel D. Karp, Sarina Piha-Paul, Vivek Subbiah, Filip Janku, Aung Naing, Timothy A. Yap, Jordi Rodon, Jaffer A. Ajani, Carrie Cartwright, Amber Johnson, I-Wen Song, Jennifer Beck, Michael Kahle, Graciela M. Nogueras-Gonzalez, Vincent Miller, Calvin Chao, David J. Vining, Donald A. Berry, Funda Meric-Bernstam, Apostolia-Maria Tsimberidou

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Early tolerance and late persistence as alternative drug responses in cancer by Simona Punzi, Davide Cittaro, Guido Gatti, Gemma Crupi, Oronza A. Botrugno, Antonino Alex Cartalemi, Alon Gutfreund, Caterina Oneto, Valentina Giansanti, Chiara Battistini, Giovanni Santacatterina, Lucrezia Patruno, Ilaria Villanti, Martina Palumbo, Daniel J. Laverty, Francesca Giannese, Alex Graudenzi, Giulio Caravagna, Marco Antoniotti, Zachary Nagel, Ugo Cavallaro, Luisa Lanfrancone, Timothy A. Yap, Giulio Draetta, Nathalie Balaban, Giovanni Tonon

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Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer by Deanna Glassman, Mark S. Kim, Meredith Spradlin, Sunil Badal, Mana Taki, Pratip Bhattacharya, Prasanta Dutta, Charles V. Kingsley, Katherine I. Foster, Olamide Animasahun, Jin Heon Jeon, Abhinav Achreja, Anusha Jayaraman, Praveen Kumar, Minal Nenwani, Fulei Wuchu, Emine Bayraktar, Yutuan Wu, Elaine Stur, Lingegowda Mangala, Sanghoon Lee, Timothy A. Yap, Shannon N. Westin, Livia S. Eberlin, Deepak Nagrath, Anil K. Sood

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