Integration of Immunome With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies by Abhinandan Devaprasad, Abhinandan Devaprasad, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Aridaman Pandit, Aridaman Pandit

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RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling by Weiyang Tao, Timothy R. D. J. Radstake, Aridaman Pandit

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Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals. by Kim C M Santegoets, Mark H Wenink, Wim B van den Berg, Timothy R D J Radstake

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Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation by Tiago Carvalheiro, Tiago Carvalheiro, Samuel Garcia, Samuel Garcia, Samuel Garcia, Samuel Garcia, M. Inês Pascoal Ramos, M. Inês Pascoal Ramos, Barbara Giovannone, Barbara Giovannone, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Wioleta Marut, Wioleta Marut, Linde Meyaard, Linde Meyaard

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Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus by Laura C. Van Eyndhoven, Laura C. Van Eyndhoven, Eleni Chouri, Eleni Chouri, Catarina I. Matos, Catarina I. Matos, Aridaman Pandit, Aridaman Pandit, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Jasper C. A. Broen, Abhyudai Singh, Jurjen Tel, Jurjen Tel

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The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis by Barbara Mariotti, Nila Hendrika Servaas, Nila Hendrika Servaas, Marzia Rossato, Marzia Rossato, Marzia Rossato, Nicola Tamassia, Marco A. Cassatella, Marta Cossu, Marta Cossu, Lorenzo Beretta, Maarten van der Kroef, Maarten van der Kroef, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Flavia Bazzoni

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High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis by Fleurieke H. Verhagen, Fleurieke H. Verhagen, Fleurieke H. Verhagen, Sanne Hiddingh, Sanne Hiddingh, Rianne Rijken, Aridaman Pandit, Aridaman Pandit, Emmerik Leijten, Emmerik Leijten, Michel Olde Nordkamp, Ninette H. ten Dam-van Loon, Stefan Nierkens, Saskia M. Imhof, Joke H. de Boer, Joke H. de Boer, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Jonas J. W. Kuiper, Jonas J. W. Kuiper, Jonas J. W. Kuiper

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Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner by Tiago Carvalheiro, Carlos Rafael-Vidal, Beatriz Malvar-Fernandez, Ana P. Lopes, Jose M. Pego-Reigosa, Timothy R. D. J. Radstake, Samuel Garcia

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Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells by Timothy R D J Radstake, Marianne Boes, Emmerik F A Leijten, Juliëtte N Pouw, Michel A M Olde Nordkamp, Tom G O'Toole

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Characterization of Long Non-Coding RNAs in Systemic Sclerosis Monocytes: A Potential Role for PSMB8-AS1 in Altered Cytokine Secretion by Nila H. Servaas, Barbara Mariotti, Maarten van der Kroef, Catharina G. K. Wichers, Aridaman Pandit, Flavia Bazzoni, Timothy R. D. J. Radstake, Marzia Rossato

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Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis by Roos A. W. Wennink, Roos A. W. Wennink, Aridaman Pandit, Anne-Mieke J. W. Haasnoot, Anne-Mieke J. W. Haasnoot, Sanne Hiddingh, Viera Kalinina Ayuso, Nico M. Wulffraat, Bas J. Vastert, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joke H. de Boer, Jonas J. W. Kuiper, Jonas J. W. Kuiper

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Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Mark Wenink, Kim Santegoets, Yanhui Deng, Anila Hussaini, Robert Simms, William W Cruikshank, Robert Lafyatis

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Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10. by Carmen A Ambarus, Kim C M Santegoets, Lenny van Bon, Mark H Wenink, Paul P Tak, Timothy R D J Radstake, Dominique L P Baeten

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Differential isoform expression of Allergin‐1 during acute and chronic inflammation by Ruben J. Geerdink, Maria Inês Pascoal Ramos, Luuk L. van denHoogen, Timothy R. D. J. Radstake, Shiro Shibayama, Akira Shibuya, Louis Bont, Linde Meyaard

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The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Anila Hussiani, Roger Hesselstrand, Dirk M Wuttge, Yanhui Deng, Robbert Simms, Erik Lubberts, Robert Lafyatis

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Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren’s Syndrome Patients Identifies CCL5 as a Novel Effector Molecule by Anneline C. Hinrichs, Anneline C. Hinrichs, Sofie L. M. Blokland, Sofie L. M. Blokland, Ana P. Lopes, Ana P. Lopes, Catharina G. K. Wichers, Catharina G. K. Wichers, Aike A. Kruize, Aridaman Pandit, Aridaman Pandit, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joel A. G. van Roon, Joel A. G. van Roon

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The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade. by Maarten R Hillen, Sarita A Y Hartgring, Cynthia R Willis, Timothy R D J Radstake, Cornelis E Hack, Floris P J G Lafeber, Joel A G van Roon

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The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators by Ana P. Lopes, Ana P. Lopes, Cornelis P. J. Bekker, Cornelis P. J. Bekker, Maarten R. Hillen, Maarten R. Hillen, Sofie L. M. Blokland, Sofie L. M. Blokland, Anneline C. Hinrichs, Anneline C. Hinrichs, Aridaman Pandit, Aridaman Pandit, Aike A. Kruize, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joel A. G. van Roon, Joel A. G. van Roon

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Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren's syndrome. by Ana P Lopes, Maarten R Hillen, Eleni Chouri, Sofie L M Blokland, Cornelis P J Bekker, Aike A Kruize, Marzia Rossato, Joel A G van Roon, Timothy R D J Radstake

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Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation by Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten, Timothy R. D. J. Radstake

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