Advancing precision oncology: Insights into the tumor microenvironment and immunotherapy outcomes by Tomotaka Ugai, Qian Yao, Satoko Ugai, Shuji Ogino

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The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities by Kosuke Mima, Tsuyoshi Hamada, Kentaro Inamura, Hideo Baba, Tomotaka Ugai, Shuji Ogino

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Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors by Claire E. Thomas, Yasutoshi Takashima, Evertine Wesselink, Tomotaka Ugai, Tomotaka Ugai, Tomotaka Ugai, Robert S. Steinfelder, Daniel D. Buchanan, Daniel D. Buchanan, Daniel D. Buchanan, Conghui Qu, Li Hsu, Li Hsu, Andressa Dias Costa, Steven Gallinger, Robert C. Grant, Jeroen R. Huyghe, Sushma S. Thomas, Shuji Ogino, Shuji Ogino, Shuji Ogino, Shuji Ogino, Amanda I. Phipps, Amanda I. Phipps, Jonathan A. Nowak, Jonathan A. Nowak, Ulrike Peters, Ulrike Peters

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Addressing the Rising Trend in Early-Age-Onset Cancers in Canada by Petra Wildgoose, Filomena Servidio-Italiano, Michael J. Raphael, Monika Slovinec D’Angelo, Cassandra Macaulay, Shaqil Kassam, Nancy Nixon, José Perea, Sarah Hamilton, Ravi Ramjeesingh, Sharlene Gill, Aaron Pollett, Shuji Ogino, Tomotaka Ugai, Abha Gupta

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HLA discrepancy between graft and host rather than that graft and first donor impact the second transplant outcome by Yoshinobu Maeda, Tomotaka Ugai, Eisei Kondo, Kazuhiro Ikegame, Makoto Murata, Naoyuki Uchida, Toshihiro Miyamoto, Satoshi Takahashi, Kazuteru Ohashi, Hirohisa Nakamae, Takahiro Fukuda, Makoto Onizuka, Tetsuya Eto, Shuichi Ota, Makoto Hirokawa, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshinobu Kanda, Junya Kanda

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Healthy and unhealthy plant‐based diets in relation to the incidence of colorectal cancer overall and by molecular subtypes by Fenglei Wang, Tomotaka Ugai, Koichiro Haruki, Yi Wan, Naohiko Akimoto, Kota Arima, Rong Zhong, Tyler S. Twombly, Kana Wu, Kanhua Yin, Andrew T. Chan, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Liming Liang, Mingyang Song, Stephanie A. Smith‐Warner, Xuehong Zhang, Edward L. Giovannucci, Walter C. Willett, Shuji Ogino

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Tumor-immune partitioning and clustering algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment. by Mai Chan Lau, Jennifer Borowsky, Juha P Väyrynen, Koichiro Haruki, Melissa Zhao, Andressa Dias Costa, Simeng Gu, Annacarolina da Silva, Tomotaka Ugai, Kota Arima, Minh N Nguyen, Yasutoshi Takashima, Joe Yeong, David Tai, Tsuyoshi Hamada, Jochen K Lennerz, Charles S Fuchs, Catherine J Wu, Jeffrey A Meyerhardt, Shuji Ogino, Jonathan A Nowak

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Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD‐L1) expression in colorectal carcinoma by Tomotaka Ugai, Takashi Shimizu, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Genki Usui, Juha P Väyrynen, Kazuo Okadome, Koichiro Haruki, Naohiko Akimoto, Yohei Masugi, Annacarolina daSilva, Kosuke Mima, Xuehong Zhang, Andrew T Chan, Molin Wang, Wendy S Garrett, Gordon J Freeman, Jeffrey A Meyerhardt, Jonathan A Nowak, Mingyang Song, Marios Giannakis, Shuji Ogino

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Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma by Tomotaka Ugai, Melissa Zhao, Takashi Shimizu, Naohiko Akimoto, Shanshan Shi, Yasutoshi Takashima, Rong Zhong, Mai Chan Lau, Koichiro Haruki, Kota Arima, Kenji Fujiyoshi, Benjamin Langworthy, Yohei Masugi, Annacarolina da Silva, Katsuhiko Nosho, Yoshifumi Baba, Mingyang Song, Andrew T. Chan, Molin Wang, Jeffrey A. Meyerhardt, Marios Giannakis, Juha P. Väyrynen, Jonathan A. Nowak, Shuji Ogino

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Histopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients by Pei-Chen Tsai, Tsung-Hua Lee, Kun-Chi Kuo, Fang-Yi Su, Tsung-Lu Michael Lee, Eliana Marostica, Tomotaka Ugai, Melissa Zhao, Mai Chan Lau, Juha P. Väyrynen, Marios Giannakis, Yasutoshi Takashima, Seyed Mousavi Kahaki, Kana Wu, Mingyang Song, Jeffrey A. Meyerhardt, Andrew T. Chan, Jung-Hsien Chiang, Jonathan Nowak, Shuji Ogino, Kun-Hsing Yu

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Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data by Melissa Zhao, Mai Chan Lau, Koichiro Haruki, Juha P. Väyrynen, Carino Gurjao, Sara A. Väyrynen, Andressa Dias Costa, Jennifer Borowsky, Kenji Fujiyoshi, Kota Arima, Tsuyoshi Hamada, Jochen K. Lennerz, Charles S. Fuchs, Reiko Nishihara, Andrew T. Chan, Kimmie Ng, Xuehong Zhang, Jeffrey A. Meyerhardt, Mingyang Song, Molin Wang, Marios Giannakis, Jonathan A. Nowak, Kun-Hsing Yu, Tomotaka Ugai, Shuji Ogino

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Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor‐infiltrating lymphocyte levels by Tomotaka Ugai, Li Liu, Fred K. Tabung, Tsuyoshi Hamada, Benjamin W. Langworthy, Naohiko Akimoto, Koichiro Haruki, Yasutoshi Takashima, Kazuo Okadome, Hidetaka Kawamura, Melissa Zhao, Seyed Mostafa Mousavi Kahaki, Jonathan N. Glickman, Jochen K. Lennerz, Xuehong Zhang, Andrew T. Chan, Charles S. Fuchs, Mingyang Song, Molin Wang, Kun‐Hsing Yu, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Kana Wu, Shuji Ogino, Edward L. Giovannucci

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Germline genetic regulation of the colorectal tumor immune microenvironment by Stephanie L. Schmit, Ya-Yu Tsai, Joseph D. Bonner, Rebeca Sanz-Pamplona, Amit D. Joshi, Tomotaka Ugai, Sidney S. Lindsey, Marilena Melas, Kevin J. McDonnell, Gregory E. Idos, Christopher P. Walker, Chenxu Qu, W. Martin Kast, Diane M. Da Silva, Jonathan N. Glickman, Andrew T. Chan, Marios Giannakis, Jonathan A. Nowak, Hedy S. Rennert, Harlan S. Robins, Shuji Ogino, Joel K. Greenson, Victor Moreno, Gad Rennert, Stephen B. Gruber

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Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analysesResearch in context by Nikos Papadimitriou, Conghui Qu, Tabitha A. Harrison, Alaina M. Bever, Richard M. Martin, Konstantinos K. Tsilidis, Polly A. Newcomb, Stephen N. Thibodeau, Christina C. Newton, Caroline Y. Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J. Pellatt, Robert E. Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D. Buchanan, Brigid M. Lynch, Stephen B. Gruber, Yin Cao, Li Hsu, Jeroen R. Huyghe, Yi Lin, Robert S. Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H. Zaidi, Amanda E. Toland, Sonja I. Berndt, Wen-Yi Huang, Elom K. Aglago, David A. Drew, Amy J. French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A. Nowak, Claire E. Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A. Jenkins, Marc J. Gunter, Peter T. Campbell, Ulrike Peters, Mingyang Song, Amanda I. Phipps, Neil Murphy

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