Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity by Congcong Zhang, Congcong Zhang, Congcong Zhang, Pranav Oberoi, Sarah Oelsner, Anja Waldmann, Aline Lindner, Torsten Tonn, Torsten Tonn, Torsten Tonn, Torsten Tonn, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels

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Anti-SARS-CoV-2 Revaccination Success in Kidney Transplant Recipients With No Initial Humoral Response Is Linked to Primary Vaccine Type by Julian Stumpf, Julian Stumpf, Jörg Schwöbel, Claudia Karger, Holger Schirutschke, René Mauer, Anna Klimova, Torsten Tonn, Torsten Tonn, Christian Hugo, Christian Hugo

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Editorial: Translating NK cell scientific research to clinical product manufacturing by Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Volker Huppert, Torsten Tonn, Wing Leung

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Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer by Nivedha Murali Shankar, Nivedha Murali Shankar, Nivedha Murali Shankar, Nivedha Murali Shankar, Paola Ortiz-Montero, Paola Ortiz-Montero, Anastasia Kurzyukova, Anastasia Kurzyukova, Wiebke Rackwitz, Wiebke Rackwitz, Stephan R. Künzel, Stephan R. Künzel, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Torsten Tonn, Torsten Tonn, Torsten Tonn, Franziska Knopf, Franziska Knopf, Jiri Eitler, Jiri Eitler

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Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting by Torsten Tonn, Winfried Wels, Jiri Eitler, Natalie Wotschel, Nicole Miller, Laurent Boissel, Hans G Klingemann

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Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo by Renata Nacasaki Silvestre, Jiri Eitler, Jiri Eitler, Julia Teixeira Cottas de Azevedo, Mariane Cariati Tirapelle, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Kamilla Swiech, Dimas Tadeu Covas, Rodrigo T. Calado, Paola Ortiz Montero, Paola Ortiz Montero, Kelen Cristina Ribeiro Malmegrim, Kelen Cristina Ribeiro Malmegrim, Marxa L. Figueiredo, Torsten Tonn, Torsten Tonn, Torsten Tonn, Virginia Picanço-Castro

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MMF/MPA Is the Main Mediator of a Delayed Humoral Response With Reduced Antibody Decline in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination by Julian Stumpf, Julian Stumpf, Torsten Siepmann, Jörg Schwöbel, Grit Glombig, Alexander Paliege, Anne Steglich, Florian Gembardt, Friederike Kessel, Hannah Kröger, Patrick Arndt, Jan Sradnick, Kerstin Frank, Anna Klimova, René Mauer, Torsten Tonn, Torsten Tonn, Christian Hugo, Christian Hugo

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442-Q CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation by Torsten Tonn, Winfried Wels, Hans Klingemann, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Paola Ortiz Montero, Wiebke Rackwitz, Venugopal Gudipati, Johannes Huppa

Palbociclib impairs the proliferative capacity of activated T cells while retaining their cytotoxic efficacy by Claudia Arndt, Claudia Arndt, Antje Tunger, Antje Tunger, Rebekka Wehner, Rebekka Wehner, Rebekka Wehner, Rebecca Rothe, Rebecca Rothe, Eleni Kourtellari, Stephanie Luttosch, Katharina Hannemann, Stefanie Koristka, Liliana R. Loureiro, Anja Feldmann, Torsten Tonn, Torsten Tonn, Torsten Tonn, Theresa Link, Theresa Link, Theresa Link, Jan Dominik Kuhlmann, Jan Dominik Kuhlmann, Jan Dominik Kuhlmann, Pauline Wimberger, Pauline Wimberger, Pauline Wimberger, Michael Philipp Bachmann, Michael Philipp Bachmann, Michael Philipp Bachmann, Michael Philipp Bachmann, Marc Schmitz, Marc Schmitz, Marc Schmitz

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EV-3, an endogenous human erythropoietin isoform with distinct functional relevance by Christel Bonnas, Liane Wüstefeld, Daniela Winkler, Romy Kronstein-Wiedemann, Ekrem Dere, Katja Specht, Melanie Boxberg, Torsten Tonn, Hannelore Ehrenreich, Herbert Stadler, Inge Sillaber

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Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A. by Stefanie D Roth, Jörg Schüttrumpf, Peter Milanov, Daniela Abriss, Christopher Ungerer, Patricia Quade-Lyssy, Jeremy C Simpson, Rainer Pepperkok, Erhard Seifried, Torsten Tonn

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Serum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer by David Digomann, Max Heiduk, Charlotte Reiche, Jessica Glück, Christoph Kahlert, Peter Mirtschink, Anna Klimova, Florian Bösch, Torsten Tonn, Jochen Gaedcke, Michael Ghadimi, Jürgen Weitz, Lena Seifert, Adrian M. Seifert

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Bortezomib promotes the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/Her2-targeted CAR-NK-92 cells via DR5 upregulation by Catrin Heim, Leonie Hartig, Nadine Weinelt, Laura M. Moser, Emilia Salzmann-Manrique, Michael Merker, Winfried S. Wels, Torsten Tonn, Peter Bader, Jan-Henning Klusmann, Sjoerd J.L. van Wijk, Eva Rettinger

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OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines by Miriam N. Jacobs, Jan M. Bult, Kevin Cavanagh, Christophe Chesne, Nathalie Delrue, Jianan Fu, Emma Grange, Ingrid Langezaal, Dominika Misztela, Jenny Murray, Martin Paparella, Gilly Stoddart, Torsten Tonn, Carol Treasure, Masaaki Tsukano, Rosemary Versteegen

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CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties by Selim Kuçi, Zyrafete Kuçi, Hermann Kreyenberg, Erika Deak, Kathrin Pütsch, Sabine Huenecke, Chandrasekhar Amara, Stefanie Koller, Eva Rettinger, Manuel Grez, Ulrike Koehl, Hatixhe Latifi-Pupovci, Reinhard Henschler, Torsten Tonn, Dorothee von Laer, Thomas Klingebiel, Peter Bader

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Perturbations of mesenchymal stromal cells after allogeneic hematopoietic cell transplantation predispose for bone marrow graft-versus-host-disease by Thomas Krüger, Thomas Krüger, Rebekka Wehner, Rebekka Wehner, Rebekka Wehner, Maik Herbig, Maik Herbig, Maik Herbig, Martin Kräter, Martin Kräter, Michael Kramer, Jan Moritz Middeke, Friedrich Stölzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlägel, Martin Wermke, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Jöhrens, Torsten Tonn, Torsten Tonn, Julien Subburayalu, Julien Subburayalu, Julien Subburayalu, Julien Subburayalu, Marc Schmitz, Marc Schmitz, Marc Schmitz, Marc Schmitz, Martin Bornhauser, Martin Bornhauser, Martin Bornhauser, Martin Bornhauser, Malte von Bonin, Malte von Bonin

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CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation by Torsten Tonn, Hans Klingemann, Winfried S Wels, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Michael Bachmann, Wiebke Rackwitz, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann

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ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma by Catrin Heim, Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Herman Kreyenberg, Halvard B. Bonig, Halvard B. Bonig, Torsten Tonn, Torsten Tonn, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Elise Gradhand, Elise Gradhand, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Michael T. Meister, Michael T. Meister, Marian Groot Koerkamp, Marian Groot Koerkamp, Frank C. P. Holstege, Frank C. P. Holstege, Jarno Drost, Jarno Drost, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Peter Bader, Peter Bader, Michael Merker, Michael Merker, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger

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Mass spectrometry-based identification of a naturally presented receptor tyrosine kinase-like orphan receptor 1-derived epitope recognized by CD8+ cytotoxic T cells by Falk Heidenreich, Elke Rücker-Braun, Juliane S. Walz, Anne Eugster, Denise Kühn, Sevina Dietz, Annika Nelde, Antje Tunger, Rebekka Wehner, Cornelia S. Link, Jan M. Middeke, Friedrich Stölzel, Torsten Tonn, Stefan Stevanovic, Hans-Georg Rammensee, Ezio Bonifacio, Michael Bachmann, Matthias Zeis, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Marc Schmitz

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C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer by Federica Portale, Roberta Carriero, Marta Iovino, Paolo Kunderfranco, Marta Pandini, Giulia Marelli, Nicolò Morina, Massimo Lazzeri, Paolo Casale, Piergiuseppe Colombo, Gabriele De Simone, Chiara Camisaschi, Enrico Lugli, Gianluca Basso, Javier Cibella, Sergio Marchini, Matteo Bordi, Greta Meregalli, Anna Garbin, Monica Dambra, Elena Magrini, Wiebke Rackwitz, Francesco Cecconi, Alessandro Corbelli, Fabio Fiordaliso, Jiri Eitler, Torsten Tonn, Diletta Di Mitri

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