Nucleic acid-based vaccines targeting respiratory syncytial virus: Delivering the goods by Trevor R. F. Smith, Katherine Schultheis, Kate E. Broderick

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Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models by Viviane M. Andrade, Igor Maricic, Richa Kalia, Lauren Jachimowicz, Olivia Bedoya, Daniel W. Kulp, Laurent Humeau, Trevor R. F. Smith

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Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation by Kate E. Broderick, Niranjan Y. Sardesai, Trevor R. F. Smith, William B. Kiosses, Christine L. Knott, Gleb Kichaev, Dinah H. Amante, Janess M. Mendoza

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Adjuvant Screen Identifies Synthetic DNA-Encoding Flt3L and CD80 Immunotherapeutics as Candidates for Enhancing Anti-tumor T Cell Responses by Amy Haseley Thorne, Kirsten N. Malo, Ashley J. Wong, Tricia T. Nguyen, Neil Cooch, Charles Reed, Jian Yan, Kate E. Broderick, Trevor R. F. Smith, Emma L. Masteller, Laurent Humeau

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Live Virus Neutralisation of the 501Y.V1 and 501Y.V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets by Shane Riddell, Sarah Goldie, Alexander J. McAuley, Michael J. Kuiper, Peter A. Durr, Kim R. Blasdell, Mary Tachedjian, Julian D. Druce, Trevor R. F. Smith, Kate E. Broderick, Seshadri S. Vasan, Seshadri S. Vasan

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Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity by Katherine Schultheis, Holly M Pugh, Janet Oh, Jacklyn Nguyen, Bryan Yung, Charles Reed, Neil Cooch, Jing Chen, Jian Yan, Kar Muthumani, Laurent M. Humeau, David B. Weiner, Kate E. Broderick, Trevor R. F. Smith

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Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine by Ghiabe H. Guibinga, Bikash Sahay, Heather Brown, Neil Cooch, Jing Chen, Jian Yan, Charles Reed, Meerambika Mishra, Bryan Yung, Holly Pugh, Katherine Schultheis, Rianne N. Esquivel, David B. Weiner, Laurent H. Humeau, Kate E. Broderick, Trevor R.F. Smith

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Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model by Kevin Hollevoet, Kevin Hollevoet, Debby Thomas, Debby Thomas, Griet Compernolle, Griet Compernolle, Giles Vermeire, Elien De Smidt, Elien De Smidt, Stéphanie De Vleeschauwer, Trevor R. F. Smith, Paul D. Fisher, Maarten Dewilde, Maarten Dewilde, Nick Geukens, Paul Declerck, Paul Declerck

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Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo by Nicholas J. Tursi, Nicholas J. Tursi, Ziyang Xu, Ziyang Xu, Michaela Helble, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H. Park, Xizhou Zhu, Megan C. Wise, Trevor R. F. Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W. Kulp, David B. Weiner

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The DNA-based Lassa vaccine INO-4500 confers durable protective efficacy in cynomolgus macaques against lethal Lassa fever by Viviane M. Andrade, Kathleen Cashman, Kyle Rosenke, Eric Wilkinson, Nicole Josleyn, Ginger Lynn, Jesse Steffens, Sean Vantongeren, Jay Wells, Connie Schmaljohn, Paul Facemire, Jingjing Jiang, Jean Boyer, Aditya Patel, Friederike Feldmann, Patrick Hanley, Jamie Lovaglio, Kimberly White, Heinz Feldmann, Stephanie Ramos, Kate E. Broderick, Laurent M. Humeau, Trevor R. F. Smith

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DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections by Sarah T. C. Elliott, Nicole L. Kallewaard, Ebony Benjamin, Leslie Wachter-Rosati, Josephine M. McAuliffe, Ami Patel, Trevor R. F. Smith, Katherine Schultheis, Daniel H. Park, Seleeke Flingai, Megan C. Wise, Janess Mendoza, Stephanie Ramos, Kate E. Broderick, Jian Yan, Laurent M. Humeau, Niranjan Y. Sardesai, Kar Muthumani, Qing Zhu, David B. Weiner

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An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model by Ami Patel, Antonio DiGiandomenico, Ashley E. Keller, Trevor R. F. Smith, Daniel H. Park, Stephanie Ramos, Katherine Schultheis, Sarah T. C. Elliott, Janess Mendoza, Kate E. Broderick, Megan C. Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kar Muthumani, Laurent Humeau, Lily I. Cheng, Leslie Wachter-Rosati, C. Kendall Stover, Niranjan Y. Sardesai, David B. Weiner

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INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants by Viviane M. Andrade, Aaron Christensen-Quick, Joseph Agnes, Jared Tur, Charles Reed, Richa Kalia, Idania Marrero, Dustin Elwood, Katherine Schultheis, Mansi Purwar, Emma Reuschel, Trevor McMullan, Patrick Pezzoli, Kim Kraynyak, Albert Sylvester, Mammen P. Mammen, Pablo Tebas, J. Joseph Kim, David B. Weiner, Trevor R. F. Smith, Stephanie J. Ramos, Laurent M. Humeau, Jean D. Boyer, Kate E. Broderick

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In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates by Ami Patel, Kyle Rosenke, Elizabeth M. Parzych, Friederike Feldmann, Suman Bharti, Amanda J. Griffin, Blake Schouest, Matt Lewis, Jihae Choi, Neethu Chokkalingam, Viviane Machado, Brian J. Smith, Drew Frase, Ali R. Ali, Jamie Lovaglio, Brian Nguyen, Patrick W. Hanley, Susanne N. Walker, Ebony N. Gary, Abhijeet Kulkarni, Allison Generotti, Joseph R. Francica, Kim Rosenthal, Daniel W. Kulp, Mark T. Esser, Trevor R. F. Smith, Carl Shaia, David B. Weiner, Heinz Feldmann

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In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model by Ami Patel, Daniel H. Park, Carl W. Davis, Trevor R.F. Smith, Anders Leung, Kevin Tierney, Aubrey Bryan, Edgar Davidson, Xiaoying Yu, Trina Racine, Charles Reed, Marguerite E. Gorman, Megan C. Wise, Sarah T.C. Elliott, Rianne Esquivel, Jian Yan, Jing Chen, Kar Muthumani, Benjamin J. Doranz, Erica Ollmann Saphire, James E. Crowe, Kate E. Broderick, Gary P. Kobinger, Shihua He, Xiangguo Qiu, Darwyn Kobasa, Laurent Humeau, Niranjan Y. Sardesai, Rafi Ahmed, David B. Weiner

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DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2 by Elizabeth M. Parzych, Jianqiu Du, Ali R. Ali, Katherine Schultheis, Drew Frase, Trevor R. F. Smith, Jiayan Cui, Neethu Chokkalingam, Nicholas J. Tursi, Viviane M. Andrade, Bryce M. Warner, Ebony N. Gary, Yue Li, Jihae Choi, Jillian Eisenhauer, Igor Maricic, Abhijeet Kulkarni, Jacqueline D. Chu, Gabrielle Villafana, Kim Rosenthal, Kuishu Ren, Joseph R. Francica, Sarah K. Wootton, Pablo Tebas, Darwyn Kobasa, Kate E. Broderick, Jean D. Boyer, Mark T. Esser, Jesper Pallesen, Dan W. Kulp, Ami Patel, David B. Weiner

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Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial by Pablo Tebas, ShuPing Yang, Jean D. Boyer, Emma L. Reuschel, Ami Patel, Aaron Christensen-Quick, Viviane M. Andrade, Matthew P. Morrow, Kimberly Kraynyak, Joseph Agnes, Mansi Purwar, Albert Sylvester, Jan Pawlicki, Elisabeth Gillespie, Igor Maricic, Faraz I. Zaidi, Kevin Y. Kim, Yaya Dia, Drew Frase, Patrick Pezzoli, Katherine Schultheis, Trevor R.F. Smith, Stephanie J. Ramos, Trevor McMullan, Karen Buttigieg, Miles W. Carroll, John Ervin, Malissa C. Diehl, Elliott Blackwood, Mammen P. Mammen, Jessica Lee, Michael J. Dallas, Ami Shah Brown, Jacqueline E. Shea, J.Joseph Kim, David B. Weiner, Kate E. Broderick, Laurent M. Humeau

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Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model by Ami Patel, Jewell N. Walters, Emma L. Reuschel, Katherine Schultheis, Elizabeth Parzych, Ebony N. Gary, Igor Maricic, Mansi Purwar, Zeena Eblimit, Susanne N. Walker, Diana Guimet, Pratik Bhojnagarwala, Opeyemi S. Adeniji, Arthur Doan, Ziyang Xu, Dustin Elwood, Sophia M. Reeder, Laurent Pessaint, Kevin Y. Kim, Anthony Cook, Neethu Chokkalingam, Brad Finneyfrock, Edgar Tello-Ruiz, Alan Dodson, Jihae Choi, Alison Generotti, John Harrison, Nicholas J. Tursi, Viviane M. Andrade, Yaya Dia, Faraz I. Zaidi, Hanne Andersen, Mohamed Abdel-Mohsen, Mark G. Lewis, Kar Muthumani, J. Joseph Kim, Daniel W. Kulp, Laurent M. Humeau, Stephanie J. Ramos, Trevor R.F. Smith, David B. Weiner, Kate E. Broderick

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Immunogenicity of a DNA vaccine candidate for COVID-19 by Trevor R. F. Smith, Ami Patel, Stephanie Ramos, Dustin Elwood, Xizhou Zhu, Jian Yan, Ebony N. Gary, Susanne N. Walker, Katherine Schultheis, Mansi Purwar, Ziyang Xu, Jewell Walters, Pratik Bhojnagarwala, Maria Yang, Neethu Chokkalingam, Patrick Pezzoli, Elizabeth Parzych, Emma L. Reuschel, Arthur Doan, Nicholas Tursi, Miguel Vasquez, Jihae Choi, Edgar Tello-Ruiz, Igor Maricic, Mamadou A. Bah, Yuanhan Wu, Dinah Amante, Daniel H. Park, Yaya Dia, Ali Raza Ali, Faraz I. Zaidi, Alison Generotti, Kevin Y. Kim, Timothy A. Herring, Sophia Reeder, Viviane M. Andrade, Karen Buttigieg, Gan Zhao, Jiun-Ming Wu, Dan Li, Linlin Bao, Jiangning Liu, Wei Deng, Chuan Qin, Ami Shah Brown, Makan Khoshnejad, Nianshuang Wang, Jacqueline Chu, Daniel Wrapp, Jason S. McLellan, Kar Muthumani, Bin Wang, Miles W. Carroll, J. Joseph Kim, Jean Boyer, Daniel W. Kulp, Laurent M. P. F. Humeau, David B. Weiner, Kate E. Broderick

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