Investigating novel mutational mechanisms for glucokinase mutations with near normal or paradoxical kinetics by Tribble, N, Beer, N, Grimsby, J, Baltrusch, S, Gloyn, A

Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy. by Turkkahraman, D, Bircan, I, Tribble, N, Akçurin, S, Ellard, S, Gloyn, A

Naturally occurring glucokinase mutations are associated with defects in posttranslational S-nitrosylation. by Ding, S, Tribble, N, Kraft, C, Markwardt, M, Gloyn, A, Rizzo, M

Functional characterisation of the glucokinase regulatory protein gene variant P446L shows diminished regulation by fructose-6 phosphate resulting in increased glucokinase activity by Beer, N, Tribble, N, Roos, C, Orho-Melander, M, Gloyn, A

Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach. by Gloyn, A, Tribble, N, van de Bunt, M, Barrett, A, Johnson, P

The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY by Steele, A, Tribble, N, Caswell, R, Wensley, K, Hattersley, A, Gloyn, A, Ellard, S

The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY. by Steele, A, Tribble, N, Caswell, R, Wensley, K, Hattersley, A, Gloyn, A, Ellard, S

Naturally occurring glucokinase mutations at the same amino acid residue cause opposite clinical phenotypes of hypo- and hyperglycaemia by Beer, N, Tribble, N, Colclough, K, Arundel, P, Grimsby, J, Chik, C, Ellard, S, Gloyn, A

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. by Beer, N, Tribble, N, McCulloch, L, Roos, C, Johnson, P, Orho-Melander, M, Gloyn, A

Identification and functional characterisation of novel inactivating glucokinase mutations causing GCK-MODY in Slovakia by Valentinova, L, Beer, N, Stanik, J, Tribble, N, Huckova, M, Gasperikova, D, Klimes, I, Gloyn, A

Identification and functional characterisation of novel glucokinase mutations causing maturity-onset diabetes of the young in Slovakia. by Valentinova, L, Beer, N, Stanik, J, Tribble, N, van de Bunt, M, Huckova, M, Barrett, A, Klimes, I, Gasperikova, D, Gloyn, A

Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation. by Christesen, H, Tribble, N, Molven, A, Siddiqui, J, Sandal, T, Brusgaard, K, Ellard, S, Njølstad, P, Alm, J, Brock Jacobsen, B, Hussain, K, Gloyn, A

Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis... by Beer, N, Osbak, K, van de Bunt, M, Tribble, N, Steele, A, Wensley, K, Edghill, E, Colcough, K, Barrett, A, Valentínová, L, Rundle, J, Raimondo, A, Grimsby, J, Ellard, S, Gloyn, A

Identification of a novel beta cell glucokinase (GCK) promoter mutation (-71 G > C) which reduces promoter activity by Gasperikova, D, Tribble, N, Stanik, J, Huckova, M, Misovicova, N, van de Bunt, M, Kuklisova, L, Barrow, B, Barak, L, Dobransky, R, Bereczkova, E, Colclough, K, Ellard, S, Klimes, I, Gloyn, A

Identification of a Novel beta-Cell Glucokinase (GCK) Promoter Mutation (-71G > C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fa... by Gasperikova, D, Tribble, N, Stanik, J, Huckova, M, Misovicova, N, van de Bunt, M, Valentinova, L, Barrow, B, Barak, L, Dobransky, R, Bereczkova, E, Michalek, J, Wicks, K, Colclough, K, Knight, J, Ellard, S, Klimes, I, Gloyn, A

Identification of a novel beta-cell glucokinase (GCK) promoter mutation (-71G>C) that modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fast... by Gasperíková, D, Tribble, N, Staník, J, Hucková, M, Misovicová, N, van de Bunt, M, Valentínová, L, Barrow, B, Barák, L, Dobránsky, R, Bereczková, E, Michálek, J, Wicks, K, Colclough, K, Knight, J, Ellard, S, Klimes, I, Gloyn, A