Pharmacogenetics – challenges and opportunities ahead by Ulrich M Zanger

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Pharmacogenomics of cytochrome P450 3A4 (CYP3A4): recent progress towards the missing heritability problem by Kathrin eKlein, Ulrich M Zanger

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MIRNA-DISTILLER: a stand-alone application to compile microRNA data from databases by Jessica K. Rieger, Denis A. Bodan, Ulrich M Zanger

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Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells by Tamara Heintze, Kathrin Klein, Ute Hofmann, Ulrich M. Zanger

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Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function by Amit V. Pandey, Amit V. Pandey, Colin J. Henderson, Yuji Ishii, Michel Kranendonk, Wayne L. Backes, Ulrich M. Zanger, Ulrich M. Zanger

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Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes by Maria Thomas, Jessica K. Rieger, Benjamin A. Kandel, Kathrin Klein, Ulrich M. Zanger

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Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response by J. E. Zhang, Kathrin Klein, Kathrin Klein, Andrea L. Jorgensen, Ben Francis, Ana Alfirevic, Stephane Bourgeois, Panagiotis Deloukas, Panagiotis Deloukas, Panagiotis Deloukas, Ulrich M. Zanger, Ulrich M. Zanger, Munir Pirmohamed

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Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis by Tamara Heintze, Tamara Heintze, Denise Wilhelm, Thierry Schmidlin, Thierry Schmidlin, Thierry Schmidlin, Ute Hofmann, Ute Hofmann, Ulrich M. Zanger, Ulrich M. Zanger, Matthias Schwab, Matthias Schwab, Matthias Schwab, Kathrin Klein, Kathrin Klein

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LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods. by Ronny Feuer, Sebastian Vlaic, Janine Arlt, Oliver Sawodny, Uta Dahmen, Ulrich M Zanger, Maria Thomas

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Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. by Yijing Zhang, Kathrin Klein, Aarathi Sugathan, Najlla Nassery, Alan Dombkowski, Ulrich M Zanger, David J Waxman

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Human Sterol Regulatory Element-Binding Protein 1a Contributes Significantly to Hepatic Lipogenic Gene Expression by Andreas Bitter, Andreas K. Nüssler, Wolfgang E. Thasler, Kathrin Klein, Ulrich M. Zanger, Matthias Schwab, Oliver Burk

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Pathway-targeted pharmacogenomics of CYP1A2 in human liver by Kathrin eKlein, Stefan eWinter, Miia eTurpeinen, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger

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A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort by Kathrin Klein, Kathrin Klein, Roman Tremmel, Roman Tremmel, Stefan Winter, Stefan Winter, Sarah Fehr, Sarah Fehr, Florian Battke, Florian Battke, Tim Scheurenbrand, Tim Scheurenbrand, Elke Schaeffeler, Elke Schaeffeler, Saskia Biskup, Saskia Biskup, Matthias Schwab, Matthias Schwab, Matthias Schwab, Matthias Schwab, Ulrich M. Zanger, Ulrich M. Zanger

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Paraoxonase (PON1 and PON3) polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis by Stephan eRiedmaier, Kathrin eKlein, Stefan eWinter, Ute eHofmann, Matthias eSchwab, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger

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Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling. by Roland Keller, Marcus Klein, Maria Thomas, Andreas Dräger, Ute Metzger, Markus F Templin, Thomas O Joos, Wolfgang E Thasler, Andreas Zell, Ulrich M Zanger

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Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8 by Maria eThomas, Stefan eWinter, Britta eKlumpp, Miia eTurpeinen, Kathrin eKlein, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger

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Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression by Hannah Asperger, Nadia Stamm, Berthold Gierke, Michael Pawlak, Ute Hofmann, Ulrich M. Zanger, Annamaria Marton, Robert L. Katona, Andrea Buhala, Csaba Vizler, Jan-Philipp Cieslik, Eugen Ruckhäberle, Dieter Niederacher, Tanja Fehm, Hans Neubauer, Marina Ludescher

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β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor by Thomas Klag, Maria Thomas, Dirk Ehmann, Lioba Courth, Daniela Mailänder-Sanchez, Thomas S. Weiss, Rania Dayoub, Kerstin Abshagen, Brigitte Vollmar, Wolfgang E. Thasler, Eduard F. Stange, Christoph P. Berg, Nisar P. Malek, Ulrich M. Zanger, Jan Wehkamp

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Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium... by Ai-Ming Yu, Magnus Ingelman-Sundberg, Nathan J. Cherrington, Lauren M. Aleksunes, Ulrich M. Zanger, Wen Xie, Hyunyoung Jeong, Edward M. Morgan, Peter J. Turnbaugh, Curtis D. Klaassen, Aadra P. Bhatt, Matthew R. Redinbo, Pengying Hao, David J. Waxman, Li Wang, Xiao-bo Zhong

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