Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level by Viktoriia Tsuber, Yunus Kadamov, Lars Brautigam, Ulrika Warpman Berglund, Thomas Helleday

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Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer by Sofia Henriksson, José Manuel Calderón-Montaño, Daniel Solvie, Ulrika Warpman Berglund, Thomas Helleday

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Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway by Jianyu Shen, Emilio Guillén Mancina, Shenyu Chen, Theodora Manolakou, Helge Gad, Ulrika Warpman Berglund, Kumar Sanjiv, Thomas Helleday

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Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids by Aleksandra Pettke, Marianna Tampere, Robin Pronk, Olov Wallner, Anna Falk, Ulrika Warpman Berglund, Thomas Helleday, Ali Mirazimi, Marjo-Riitta Puumalainen

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A phenomics approach for antiviral drug discovery by Jonne Rietdijk, Marianna Tampere, Aleksandra Pettke, Polina Georgiev, Maris Lapins, Ulrika Warpman-Berglund, Ola Spjuth, Marjo-Riitta Puumalainen, Jordi Carreras-Puigvert

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In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization by Maurice Michel, Evert J. Homan, Elisée Wiita, Kia Pedersen, Ingrid Almlöf, Anna-Lena Gustavsson, Thomas Lundbäck, Thomas Lundbäck, Thomas Helleday, Thomas Helleday, Ulrika Warpman Berglund

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Karonudib is a promising anticancer therapy in hepatocellular carcinoma by Xiangwei Hua, Kumar Sanjiv, Helge Gad, Therese Pham, Camilla Gokturk, Azita Rasti, Zhenjun Zhao, Kang He, Mingxuan Feng, Yunjin Zang, Jianjun Zhang, Qiang Xia, Thomas Helleday, Ulrika Warpman Berglund

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The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation by Petra Marttila, Nadilly Bonagas, Christina Chalkiadaki, Hannah Stigsdotter, Korbinian Schelzig, Jianyu Shen, Crystal M. Farhat, Amber Hondema, Julian Albers, Elisée Wiita, Azita Rasti, Ulrika Warpman Berglund, Ana Slipicevic, Oliver Mortusewicz, Thomas Helleday

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TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model by Brice Moukengue, Hannah K Brown, Céline Charrier, Séverine Battaglia, Marc Baud'huin, Thibaut Quillard, Therese M Pham, Ioannis S Pateras, Vassilis G Gorgoulis, Thomas Helleday, Dominique Heymann, Ulrika Warpman Berglund, Benjamin Ory, Francois Lamoureux

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Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma by Morten P. Oksvold, Ulrika Warpman Berglund, Helge Gad, Baoyan Bai, Trond Stokke, Idun Dale Rein, Therese Pham, Kumar Sanjiv, Geir Frode Øy, Jens Henrik Norum, Erlend B. Smeland, June H. Myklebust, Thomas Helleday, Thea Kristin Våtsveen

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Computational and Experimental Druggability Assessment of Human DNA Glycosylases by Maurice Michel, Torkild Visnes, Evert J. Homan, Brinton Seashore-Ludlow, Mattias Hedenström, Elisée Wiita, Karl Vallin, Cynthia B. J. Paulin, Jiaxi Zhang, Olov Wallner, Martin Scobie, Andreas Schmidt, Annika Jenmalm-Jensen, Ulrika Warpman Berglund, Thomas Helleday

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities by Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M. Reaper, Oliver Mortusewicz, Sylvain A. Jacques, Raoul V. Kuiper, Niklas Schultz, Martin Scobie, Peter A. Charlton, John R. Pollard, Ulrika Warpman Berglund, Mikael Altun, Thomas Helleday

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Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses by Marianna Tampere, Aleksandra Pettke, Cristiano Salata, Olov Wallner, Tobias Koolmeister, Armando Cazares-Körner, Torkild Visnes, Maria Carmen Hesselman, Elena Kunold, Elisee Wiita, Christina Kalderén, Molly Lightowler, Ann-Sofie Jemth, Janne Lehtiö, Åsa Rosenquist, Ulrika Warpman-Berglund, Thomas Helleday, Ali Mirazimi, Rozbeh Jafari, Marjo-Riitta Puumalainen

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Virtual fragment screening for DNA repair inhibitors in vast chemical space by Andreas Luttens, Duc Duy Vo, Emma R. Scaletti, Elisée Wiita, Ingrid Almlöf, Olov Wallner, Jonathan Davies, Sara Košenina, Liuzhen Meng, Maeve Long, Oliver Mortusewicz, Geoffrey Masuyer, Flavio Ballante, Maurice Michel, Evert Homan, Martin Scobie, Christina Kalderén, Ulrika Warpman Berglund, Andrii V. Tarnovskiy, Dmytro S. Radchenko, Yurii S. Moroz, Jan Kihlberg, Pål Stenmark, Thomas Helleday, Jens Carlsson

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Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming by Ioannis S. Pateras, Chloe Williams, Despoina D. Gianniou, Aggelos T. Margetis, Margaritis Avgeris, Pantelis Rousakis, Aigli-Ioanna Legaki, Peter Mirtschink, Wei Zhang, Konstantina Panoutsopoulou, Anastasios D. Delis, Stamatis N. Pagakis, Wei Tang, Stefan Ambs, Ulrika Warpman Berglund, Thomas Helleday, Anastasia Varvarigou, Antonios Chatzigeorgiou, Anders Nordström, Ourania E. Tsitsilonis, Ioannis P. Trougakos, Jonathan D. Gilthorpe, Teresa Frisan

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Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy by Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia BJ Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman‐Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan‐Inge Henter, Torsten Schaller, Thomas Helleday, Nikolas Herold

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