A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers by Ersen Kameri, Ersen Kameri, Ersen Kameri, Vera Helena Jepsen, Pawel Stachura, Pawel Stachura, Nadine Rüchel, Rigveda Bhave, Leticia Benitez, Fatima Crispi, Eduard Gratacos, Nico Dragano, Stefan Janssen, Arndt Borkhardt, Arndt Borkhardt, Aleksandra Pandyra, Aleksandra Pandyra, Aleksandra Pandyra, Gesine Kögler, Gesine Kögler, Ute Fischer, Ute Fischer, Ute Fischer

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Resolving inherited and de novo germline predisposing sequence variants by means of whole exome trio analyses in childhood hematological malignancies by Triantafyllia Brozou, Layal Yasin, Danielle Brandes, Daniel Picard, Carolin Walter, Julian Varghese, Martin Dugas, Ute Fischer, Arndt Borkhardt, Oskar A. Haas

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CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL by Ute Fischer, Christian Ruckert, Bernd Hubner, Olaf Eckermann, Vera Binder, Tamam Bakchoul, Friedhelm R. Schuster, Sylvia Merk, Hans-Ulrich Klein, Monika Führer, Martin Dugas, Arndt Borkhardt

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Next-generation-sequencing-spectratyping reveals public T-cell receptor repertoires in pediatric very severe aplastic anemia and identifies a β chain CDR3 sequence associated with... by Pina F. I. Krell, Susanne Reuther, Ute Fischer, Thomas Keller, Stephan Weber, Michael Gombert, Friedhelm R. Schuster, Corinna Asang, Polina Stepensky, Brigitte Strahm, Roland Meisel, Jens Stoye, Arndt Borkhardt

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Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease by Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Hönscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer

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Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing by Christoph Bartenhagen, Ute Fischer, Klaus Korn, Stefan M. Pfister, Michael Gombert, Cai Chen, Vera Okpanyi, Julia Hauer, Anna Rinaldi, Jean-Pierre Bourquin, Cornelia Eckert, Jianda Hu, Armin Ensser, Martin Dugas, Arndt Borkhardt

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Optical Genome Mapping Identifies Novel Recurrent Structural Alterations in Childhood ETV6::RUNX1+ and High Hyperdiploid Acute Lymphoblastic Leukemia by Danielle Brandes, Layal Yasin, Karin Nebral, Jana Ebler, Dagmar Schinnerl, Daniel Picard, Anke K. Bergmann, Jubayer Alam, Stefan Köhrer, Oskar A. Haas, Andishe Attarbaschi, Tobias Marschall, Martin Stanulla, Arndt Borkhardt, Triantafyllia Brozou, Ute Fischer, Rabea Wagener

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Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans by Cyrill Schipp, Schafiq Nabhani, Kirsten Bienemann, Natalia Simanovsky, Shlomit Kfir-Erenfeld, Nathalie Assayag-Asherie, Prasad T. Oommen, Shoshana Revel-Vilk, Andrea Hönscheid, Michael Gombert, Sebastian Ginzel, Daniel Schäfer, Hans-Jürgen Laws, Eitan Yefenof, Bernhard Fleckenstein, Arndt Borkhardt, Polina Stepensky, Ute Fischer

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P330: PROTEOMIC PROFILING UNCOVERS THERAPEUTIC VULNERABILITIES FOR TCF3 TRANSLOCATED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS by Rebecca Hasselmann, Lena Blümel, Flavia Bernardi, Daniel Picard, Jacob Torrejon-Diaz, Vera Jepsen, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovca, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourquin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

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Hyperdiploid acute lymphoblastic leukemia in children with LZTR1 germline variants by Lisa Zipper, Rabea Wagener, Ute Fischer, Anna Hoffmann, Layal Yasin, Danielle Brandes, Stavrieta Soura, Ammarah Anwar, Carolin Walter, Julian Varghese, Julia Hauer, Franziska Auer, Sanil Bhatia, Martin Dugas, Stefanie V. Junk, Martin Stanulla, Oskar A. Haas, Arndt Borkhardt, Tobias Reiff, Triantafyllia Brozou

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Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens by Nadine Rüchel, Marina Oldenburg, Stefan Janssen, Aleksandra A. Pandyra, Wei Liu, Eleni Vasileiou, Daniel Hein, Vera Helena Jepsen, Ute Fischer, Daniel Picard, Gesine Kögler, Julia Hauer, Franziska Auer, Angelina Beer, Ortwin Adams, Colin MacKenzie, Martin Jaeger, Mihai G. Netea, Arndt Borkhardt, Katharina L. Gössling

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Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia by Lena Blumel, Flavia Bernardi, Daniel Picard, Jacob Torrejon Diaz, Vera H. Jepsen, Rebecca Hasselmann, Julian Schliehe-Diecks, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovka, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourqin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

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Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells by Melina Vogt, Niklas Dienstbier, Julian Schliehe-Diecks, Katerina Scharov, Jia-Wey Tu, Philip Gebing, Julian Hogenkamp, Berna-Selin Bilen, Silke Furlan, Daniel Picard, Marc Remke, Layal Yasin, David Bickel, Munishikha Kalia, Alfredo Iacoangeli, Thomas Lenz, Kai Stühler, Aleksandra A. Pandyra, Julia Hauer, Ute Fischer, Rabea Wagener, Arndt Borkhardt, Sanil Bhatia

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A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B‐cell lymphoma by Maria Joosten, Sebastian Ginzel, Christian Blex, Dmitri Schmidt, Michael Gombert, Cai Chen, René Martin Linka, Olivia Gräbner, Anika Hain, Burkhard Hirsch, Anke Sommerfeld, Anke Seegebarth, Uschi Gruber, Corinna Maneck, Langhui Zhang, Katharina Stenin, Henrik Dieks, Michael Sefkow, Carsten Münk, Claudia D. Baldus, Ralf Thiele, Arndt Borkhardt, Michael Hummel, Hubert Köster, Ute Fischer, Mathias Dreger, Volkhard Seitz

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Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets by Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Kloetgen, Michael Gombert, Ute Fischer, Daniel Hein, Salih Demir, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Beat Bornhauser, Jean-Pierre Bourquin, Stefan Krause, Juergen Enczmann, Lüder Hinrich Meyer, Cornelia Eckert, Arndt Borkhardt, Roland Meisel

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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

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