Reverse-Design toward Optimized Labeled Chemical Probes – Examples from the Endocannabinoid System by Mónica Guberman, Miroslav Kosar, Anahid Omran, Erick M. Carreira, Marc Nazaré, Uwe Grether

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Late-stage Functionalization and its Impact on Modern Drug Discovery by David F. Nippa, Remo Hohler, Antonia F. Stepan, Uwe Grether, David B. Konrad, Rainer E. Martin

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Editorial: Therapeutic potential of the cannabinoid CB2 receptor by Reem Smoum, Uwe Grether, Meliha Karsak, Andrea J. Vernall, Frank Park, Cecilia J. Hillard, Pal Pacher

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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature by Alicia M. Kemble, Benoit Hornsperger, Iris Ruf, Hans Richter, Jörg Benz, Bernd Kuhn, Dominik Heer, Matthias Wittwer, Britta Engelhardt, Uwe Grether, Ludovic Collin

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Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening by David F. Nippa, Kenneth Atz, Alex T. Müller, Jens Wolfard, Clemens Isert, Martin Binder, Oliver Scheidegger, David B. Konrad, Uwe Grether, Rainer E. Martin, Gisbert Schneider

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Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice by Claudia Gonzalo-Consuegra, Irene Santos-García, Laura García-Toscano, Raquel Martín-Baquero, Carmen Rodríguez-Cueto, Matthias B. Wittwer, Pawel Dzygiel, Uwe Grether, Eva de Lago, Javier Fernández-Ruiz

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Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis by Richard Frederick Porter, Anna-Maria Szczesniak, James Thomas Toguri, Simon Gebremeskel, Brent Johnston, Christian Lehmann, Jürgen Fingerle, Benno Rothenhäusler, Camille Perret, Mark Rogers-Evans, Atsushi Kimbara, Matthias Nettekoven, Wolfgang Guba, Uwe Grether, Christoph Ullmer, Melanie E. M. Kelly

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Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors by Morgan Scott-Dennis, Morgan Scott-Dennis, Fikri A. Rafani, Fikri A. Rafani, Yicheng Yi, Yicheng Yi, Themiya Perera, Themiya Perera, Clare R. Harwood, Clare R. Harwood, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Dmitry B. Veprintsev, Dmitry B. Veprintsev, Dmitry B. Veprintsev, David A. Sykes, David A. Sykes, David A. Sykes

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Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease by Samuel Ruiz de Martín Esteban, Irene Benito-Cuesta, Itziar Terradillos, Itziar Terradillos, Ana M. Martínez-Relimpio, M. Andrea Arnanz, Gonzalo Ruiz-Pérez, Claudia Korn, Catarina Raposo, Roman C. Sarott, Matthias V. Westphal, Izaskun Elezgarai, Izaskun Elezgarai, Erick M. Carreira, Cecilia J. Hillard, Uwe Grether, Pedro Grandes, Pedro Grandes, M. Teresa Grande, Julián Romero

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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity by Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, Travis W. Grim, Filomena Fezza, Luciano de Petrocellis, Christoph Ullmer, Benno Rothenhäusler, Camille Perret, Noortje van Gils, David Finlay, Christa MacDonald, Andrea Chicca, Marianela Dalghi Gens, Jordyn Stuart, Henk de Vries, Nicolina Mastrangelo, Lizi Xia, Georgios Alachouzos, Marc P. Baggelaar, Andrea Martella, Elliot D. Mock, Hui Deng, Laura H. Heitman, Mark Connor, Vincenzo Di Marzo, Jürg Gertsch, Aron H. Lichtman, Mauro Maccarrone, Pal Pacher, Michelle Glass, Mario van der Stelt

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A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence by Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt

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