TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling by Camilla Heiniö, Riikka Havunen, Joao Santos, Klaas de Lint, Victor Cervera-Carrascon, Anna Kanerva, Akseli Hemminki

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Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control by Dafne C. A. Quixabeira, Sadia Zafar, Joao M. Santos, Joao M. Santos, Victor Cervera-Carrascon, Victor Cervera-Carrascon, Riikka Havunen, Riikka Havunen, Tatiana V. Kudling, Saru Basnet, Marjukka Anttila, Anna Kanerva, Anna Kanerva, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

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Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1 by Riikka Havunen, Riikka Kalliokoski, Mikko Siurala, Suvi Sorsa, João M. Santos, Victor Cervera-Carrascon, Marjukka Anttila, Akseli Hemminki

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Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers by Joao Santos, Camilla Heiniö, Dafne Quixabeira, Sadia Zafar, James Clubb, Santeri Pakola, Victor Cervera-Carrascon, Riikka Havunen, Anna Kanerva, Akseli Hemminki

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Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus by Riikka Havunen, João M. Santos, Suvi Sorsa, Tommi Rantapero, Dave Lumen, Mikko Siurala, Anu J. Airaksinen, Victor Cervera-Carrascon, Siri Tähtinen, Anna Kanerva, Akseli Hemminki

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A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma by Cristian Capasso, Aniket Magarkar, Victor Cervera-Carrascon, Manlio Fusciello, Sara Feola, Martin Muller, Mariangela Garofalo, Lukasz Kuryk, Siri Tähtinen, Lucio Pastore, Alex Bunker, Vincenzo Cerullo

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Effective Combination Immunotherapy with Oncolytic Adenovirus and Anti-PD-1 for Treatment of Human and Murine Ovarian Cancers by Camilla Heiniö, James Clubb, Tatiana Kudling, Dafne Quixabeira, Victor Cervera-Carrascon, Riikka Havunen, Susanna Grönberg-Vähä-Koskela, João Manuel Santos, Johanna Tapper, Anna Kanerva, Akseli Hemminki

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Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation by Víctor González-Ruiz, Ángel Cores, Olmo Martín-Cámara, Karen Orellana, Víctor Cervera-Carrascón, Patrycja Michalska, Ana I. Olives, Rafael León, M. Antonia Martín, J. Carlos Menéndez

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Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1 by Victor Cervera-Carrascon, Victor Cervera-Carrascon, Dafne C. A. Quixabeira, Joao M. Santos, Joao M. Santos, Riikka Havunen, Riikka Havunen, Ioanna Milenova, Ioanna Milenova, Jan Verhoeff, Camilla Heiniö, Sadia Zafar, Juan J. Garcia-Vallejo, Victor W. van Beusechem, Tanja D. de Gruijl, Aino Kalervo, Suvi Sorsa, Anna Kanerva, Anna Kanerva, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

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CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy by Sadia Zafar, Suvi Sorsa, Mikko Siurala, Otto Hemminki, Riikka Havunen, Victor Cervera-Carrascon, João Manuel Santos, Hongjie Wang, Andre Lieber, Tanja De Gruijl, Anna Kanerva, Akseli Hemminki

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Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity by Akseli Hemminki, Víctor Cervera-Carrascón, Mikko Siurala, Riikka Havunen, Sadia Zafar, Tanja de Gruijl, Anna Kanerva, João Manuel Santos, Camilla Heiniö, Dafne C A Quixabeira, Ralf Butzow, Heini Lassus

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Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer by James H. A. Clubb, James H. A. Clubb, James H. A. Clubb, Tatiana V. Kudling, Tatiana V. Kudling, Camilla Heiniö, Camilla Heiniö, Saru Basnet, Saru Basnet, Santeri Pakola, Santeri Pakola, Víctor Cervera Carrascón, Víctor Cervera Carrascón, Víctor Cervera Carrascón, João Manuel Santos, João Manuel Santos, João Manuel Santos, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Riikka Havunen, Riikka Havunen, Riikka Havunen, Suvi Sorsa, Suvi Sorsa, Suvi Sorsa, Vincent Zheng, Vincent Zheng, Tuula Salo, Tuula Salo, Tuula Salo, Tuula Salo, Tuula Salo, Leif Bäck, Leif Bäck, Katri Aro, Katri Aro, Sanni Tulokas, Venla Loimu, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

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An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartmen... by Santeri Pakola, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Tatiana V. Kudling, James H. A. Clubb, James H. A. Clubb, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, Saru Basnet, Elise Jirovec, Elise Jirovec, Victor Arias, Lyna Haybout, Lyna Haybout, Camilla Heiniö, Joao M. Santos, Joao M. Santos, Victor Cervera-Carrascon, Victor Cervera-Carrascon, Riikka Havunen, Riikka Havunen, Marjukka Anttila, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

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805 Oncolytic adenovirus encoding human interleukin-7 in combination with ICIs as a treatment strategy against renal cell carcinoma (RCC) by Akseli Hemminki, Víctor Cervera-Carrascón, Otto Hemminki, João Manuel Santos, Saru Basnet, Santeri A Pakola, James Clubb, Elise Jirovec, Dafne CA Quixabeira, Tatiana Kudling, Lyna Haybout, Susanna AM Grönberg-Vähä-Koskela, Victor Arias

Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 by Dafne C. A. Quixabeira, Victor Cervera-Carrascon, Joao M. Santos, James H.A. Clubb, Tatiana V. Kudling, Saru Basnet, Camilla Heiniö, Susanna Grönberg-Vähä-Koskela, Marjukka Anttila, Riikka Havunen, Anna Kanerva, Akseli Hemminki

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739 Emerging proteomic and safety analysis of blood from solid tumor patients receiving TILT-123 (Ad5/3-E2F-d24-hTNFa-IRES-hIL2) monotherapy in TUNIMO phase 1 clinical trial by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, João Santos, Riikka Havunen, Juha Kononen, Jorma Sormunen, Katriina Peltola, Riitta Korpisaari, Marjut Jaakkola, Suvi Sorsa, Santeri A Pakola, James Clubb, Elise Jirovec, Dafne CA Quixabeira, Tatiana Kudling, Lyna Haybout, Claudia Kistler

745 Immune cell profiling of advanced-stage solid tumors patients treated with an oncolytic adenovirus encoding for TNF-a and IL-2 (TILT-123) by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, João Santos, Riikka Havunen, Juha Kononen, Jorma Sormunen, Katriina Peltola, Riitta Korpisaari, Susanna Juteau, Marjut Jaakkola, Suvi Sorsa, Santeri A Pakola, James Clubb, Elise Jirovec, Dafne CA Quixabeira, Tatiana Kudling, Lyna Haybout, Claudia Kistler

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition by Victor Cervera-Carrascon, Dafne C.A. Quixabeira, Joao Manuel Santos, Riikka Havunen, Sadia Zafar, Otto Hemminki, Camilla Heiniö, Eleonora Munaro, Mikko Siurala, Suvi Sorsa, Tuomas Mirtti, Petrus Järvinen, Markus Mildh, Harry Nisen, Antti Rannikko, Marjukka Anttila, Anna Kanerva, Akseli Hemminki

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711 Development of oncolytic adenovirus Ad5/3-E2F-D24-hTNFa-IRES-hIL2 (TILT-123) for the treatment of solid tumours – from preclinical testing to phase I clinical trials by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, Riikka Havunen, João Manuel Santos, Juha Kononen, Jorma Sormunen, Katriina Peltola, Riitta Korpisaari, Marjut Jaakkola, Suvi Sorsa, Santeri A Pakola, James Clubb, Elise Jirovec, Dafne CA Quixabeira, Tatiana Kudling, Lyna Haybout, Claudia Kistler

Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors by Saru Basnet, Joao M. Santos, Dafne C.A. Quixabeira, James H.A. Clubb, Susanna A.M. Grönberg-Vähä-Koskela, Victor Arias, Santeri Pakola, Tatiana V. Kudling, Camilla Heiniö, Riikka Havunen, Victor Cervera-Carrascon, Suvi Sorsa, Marjukka Anttila, Anna Kanerva, Akseli Hemminki

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