S108: ATP CITRATE LYASE IS AN ESSENTIAL PLAYER OF THE METABOLIC REWIRING INDUCED BY PTEN LOSS DURING T-ALL DEVELOPMENT by Guillaume Andrieu, Guillaume Andrieu, Estelle Balduci, Caroline Costa, Els Verhoeyen, Ivan Nemazanyy, Ganna Pannasiuk, Kathryn Wellen, Elizabeth Macintyre, Vahid Asnafi, Melania Tesio

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Impact of T-cell Receptor Status on Mutational Landscape and Outcome in T-ALL by Marie Emilie Dourthe, Lucien Courtois, Guillaume P. Andrieu, Mathieu Simonin, Aurore Touzart, Ludovic Lhermitte, Arnaud Petit, Nicolas Boissel, André Baruchel, Vahid Asnafi, Elizabeth Macintyre

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CBFβ-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acute Myeloid Leukemia by Gaëlle Cordonnier, Amit Mandoli, Nicolas Cagnard, Guillaume Hypolite, Ludovic Lhermitte, Els Verhoeyen, Vahid Asnafi, Niall Dillon, Elizabeth Macintyre, Joost H.A. Martens, Jonathan Bond

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S106: METABOLIC PLASTICITY REVEALS A TARGETABLE VULNERABILITY IN LEUKEMIA by Guillaume Andrieu, Mathieu Simonin, Aurélie Cabannes-Hamy, Etienne Lengliné, Ambroise Marçais, Marie-Emilie Dourthe, Alexandre Theron, Nicolas Boissel, Hervé Dombret, Philippe Rousselot, Olivier Hermine, Vahid Asnafi

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INTRAEPITHELIAL LYMPHOCYTOSIS QUANTIFICATION BY MACHINE LEARNING IN CELIAC DISEASE. A CELAC STUDY by Julie Bruneau, Sarah Makri, Pierre Isnard, Shérine Khater, LudovicLhermitte, Saima Ben Hadj, Laura Stantinat, Nicolas Goudin, Vahid Asnafi, Christophe Cellier, Olivier Hermine, Thierry-Jo Molina

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Toward Pediatric T Lymphoblastic Lymphoma Stratification Based on Minimal Disseminated Disease and NOTCH1/FBXW7 Status by Amélie Trinquand, Adriana Plesa, Chrystelle Abdo, Fabien Subtil, Nathalie Aladjidi, Charlotte Rigaud, Aurore Touzart, Ludovic Lhermitte, Arnaud Petit, Katell Michaux, Charlotte Jung, Catherine Chassagne-Clement, Vahid Asnafi, Yves Bertrand, Nathalie Garnier, Elizabeth Macintyre

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P321: TNF-MEDIATED CELL DEATH: AN ACTIONABLE TARGET FOR IMMUNOTHERAPY IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA by Marie-Emilie Dourthe, Etienne Lengline, Guillaume Charbonnier, Mehdi Latiri, Chaimae Saji, Agata Cieslak, Mathieu Simonin, Norbert Ifrah, Hervé Dombret, Olivier Hermine, Nicolas Boissel, André Baruchel, Jacques Ghysdael, Elizabeth Macintyre, Christine Tran-Quang, Guillaume Andrieu, Vahid Asnafi

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P319: IL7-RECEPTOR EXPRESSION IS FREQUENT IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND PREDICTS SENSITIVITY TO JAK-INHIBITION by Lucien Courtois, Aurélie Cabannes-Hamy, Rathana Kim, Marine Delecourt, Antoine Pinton, Guillaume Charbonnier, Melanie Feroul, Charlotte Smith, Giulia Tueur, Cecile Pivert, Estelle Balducci, Mathieu Simonin, Salvatore Spicuglia, Nicolas Boissel, Guillaume Andrieu, Vahid Asnafi, Philippe Rousselot, Ludovic Lhermitte

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BLNK mutation associated with T-cell LGL leukemia and autoimmune diseases: Case report in hematology by Guillemette Fouquet, Guillemette Fouquet, Guillemette Fouquet, Julien Rossignol, Laure Ricard, Flavia Guillem, Flavia Guillem, Lucile Couronné, Vahid Asnafi, Manon Vavasseur, Mélanie Parisot, Nicolas Garcelon, Frédéric Rieux-Laucat, Arsène Mekinian, Arsène Mekinian, Olivier Hermine, Olivier Hermine, Olivier Hermine

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Germinal epimutation of Fragile Histidine Triad (FHIT) gene is associated with progression to acute and chronic adult T-cell leukemia diseases by Marcia Bellon, Izabela Bialuk, Veronica Galli, Xue-Tao Bai, Lourdes Farre, Achilea Bittencourt, Ambroise Marçais, Michael N. Petrus, Lee Ratner, Thomas A. Waldmann, Vahid Asnafi, Antoine Gessain, Masao Matsuoka, Genoveffa Franchini, Olivier Hermine, Toshiki Watanabe, Christophe Nicot

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The Need for a Consensus Next-generation Sequencing Panel for Mature Lymphoid Malignancies by Pierre Sujobert, Yannick Le Bris, Laurence de Leval, Audrey Gros, Jean Philippe Merlio, Cedric Pastoret, Sarah Huet, Clémentine Sarkozy, Frédéric Davi, Mary Callanan, Catherine Thieblemont, David Sibon, Vahid Asnafi, Claude Preudhomme, Philippe Gaulard, Fabrice Jardin, Gilles Salles, Elizabeth Macintyre

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Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation by Kutaiba Alhaj Hussen, Emna Chabaane, Elisabeth Nelson, Shalva Lekiashvili, Samuel Diop, Seydou Keita, Bertrand Evrard, Aurélie Lardenois, Marc Delord, Els Verhoeyen, Kerstin Cornils, Zeinab Kasraian, Elizabeth A. Macintyre, Ana Cumano, David Garrick, Michele Goodhardt, Guillaume P. Andrieu, Vahid Asnafi, Frederic Chalmel, Bruno Canque

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Harnessing the MYB-dependent TAL1 5’super-enhancer for targeted therapy in T-ALL by Charlotte Smith, Aurore Touzart, Mathieu Simonin, Christine Tran-Quang, Guillaume Hypolite, Mehdi Latiri, Guillaume P. Andrieu, Estelle Balducci, Marie-Émilie Dourthe, Ashish Goyal, Françoise Huguet, Arnaud Petit, Norbert Ifrah, André Baruchel, Hervé Dombret, Elizabeth Macintyre, Christoph Plass, Jacques Ghysdael, Nicolas Boissel, Vahid Asnafi

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TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2 by Estelle Balducci, Thomas Steimlé, Charlotte Smith, Patrick Villarese, Mélanie Feroul, Dominique Payet-Bornet, Sophie Kaltenbach, Lucile Couronné, Ludovic Lhermitte, Aurore Touzart, Marie-Emilie Dourthe, Mathieu Simonin, André Baruchel, Hervé Dombret, Norbert Ifrah, Nicolas Boissel, Bertrand Nadel, Elizabeth Macintyre, Agata Cieslak, Vahid Asnafi

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Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL by Mathieu Simonin, Aline Schmidt, Christophe Bontoux, Marie-Émilie Dourthe, Etienne Lengliné, Guillaume P. Andrieu, Ludovic Lhermitte, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Françoise Huguet, Isabelle Arnoux, Stéphane Ducassou, Elizabeth Macintyre, Virginie Gandemer, Hervé Dombret, Arnaud Petit, Norbert Ifrah, André Baruchel, Nicolas Boissel, Vahid Asnafi

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ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases. by Gandhi Damaj, Magalie Joris, Olivia Chandesris, Katia Hanssens, Erinn Soucie, Danielle Canioni, Brigitte Kolb, Isabelle Durieu, Emanuel Gyan, Cristina Livideanu, Stephane Chèze, Momar Diouf, Reda Garidi, Sophie Georgin-Lavialle, Vahid Asnafi, Ludovic Lhermitte, Christian Lavigne, David Launay, Michel Arock, Olivier Lortholary, Patrice Dubreuil, Olivier Hermine

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Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. by Daniella Arêas Mendes-da-Cruz, Anne Colette Brignier, Vahid Asnafi, Frederic Baleydier, Carolina Valença Messias, Yves Lepelletier, Nawel Bedjaoui, Amedée Renand, Salete Smaniotto, Danielle Canioni, Pierre Milpied, Karl Balabanian, Philippe Bousso, Stéphane Leprêtre, Yves Bertrand, Hervé Dombret, Norbert Ifrah, Mireille Dardenne, Elizabeth Macintyre, Wilson Savino, Olivier Hermine

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From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia by Magali Saez-Ayala, Laurent Hoffer, Sébastien Abel, Khaoula Ben Yaala, Benoit Sicard, Guillaume P. Andrieu, Mehdi Latiri, Emma K. Davison, Marco A. Ciufolini, Paul Brémond, Etienne Rebuffet, Philippe Roche, Carine Derviaux, Edwige Voisset, Camille Montersino, Remy Castellano, Yves Collette, Vahid Asnafi, Stéphane Betzi, Patrice Dubreuil, Sébastien Combes, Xavier Morelli

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Optical genome mapping refines cytogenetic diagnostics, prognostic stratification and provides new molecular insights in adult MDS/AML patients by Estelle Balducci, Sophie Kaltenbach, Patrick Villarese, Eugénie Duroyon, Loria Zalmai, Chloé Friedrich, Felipe Suarez, Ambroise Marcais, Didier Bouscary, Justine Decroocq, Rudy Birsen, Michaëla Fontenay, Marie Templé, Chantal Brouzes, Aurore Touzart, Thomas Steimlé, Agata Cieslak, Ludovic Lhermitte, Carole Almire, Nicolas Chapuis, Olivier Hermine, Vahid Asnafi, Olivier Kosmider, Lucile Couronné

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P1166: BRIGATINIB IN PATIENTS WITH ALK-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA WHO HAVE FAILED BRENTUXIMAB VEDOTIN by Layla Veleanu, Bruno Tesson, Laurence Lamant, Ambroise Marçais, Julie Bruneau, Sophie Kaltenbach, Chantal Brouzes, Charlotte Degoutte, Josquin Moraly, Patrick Villarese, Ludovic Lhermitte, Mehdi Latiri, Gregoire Hure, Adrien Chauchet, Caroline Delette, Sylvie Grosleron, Elise Toussaint, Quentin Cabrera, Pauline Brice, Francois-Xavier Gros, Aline Clavert, Lucie Oberic, Marielle Legoff, Sophie Cereja, Fabienne Meggetto, Elizabeth Macintyre, Vahid Asnafi, David Sibon

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