Targeting ABCG1 and SREBP-2 mediated cholesterol homeostasis ameliorates Zika virus-induced ocular pathology by Sneha Singh, Robert E. Wright, III, Shailendra Giri, Vaithilingaraja Arumugaswami, Ashok Kumar

Get full text

Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection by Arun Sharma, Gustavo Garcia, Jr., Yizhou Wang, Jasmine T. Plummer, Kouki Morizono, Vaithilingaraja Arumugaswami, Clive N. Svendsen

Get full text

Viral and Host Small RNA Response to SARS-CoV-2 Infection by Guihua Sun, Qi Cui, Gustavo Garcia, Elizabeth M. Lizhar, Vaithilingaraja Arumugaswami, Yanhong Shi, Arthur D. Riggs

Get full text

In Silico Genome Analysis Reveals the Evolution and Potential Impact of SARS-CoV-2 Omicron Structural Changes on Host Immune Evasion and Antiviral Therapeutics by Dhruv Chauhan, Nikhil Chakravarty, Arjit Vijey Jeyachandran, Akshaya Jayakarunakaran, Sanjeev Sinha, Rakesh Mishra, Vaithilingaraja Arumugaswami, Arunachalam Ramaiah

Get full text

Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection by Qi Cui, Gustavo Garcia, Jr., Mingzi Zhang, Cheng Wang, Hongzhi Li, Tao Zhou, Guihua Sun, Vaithilingaraja Arumugaswami, Yanhong Shi

Get full text

Replication-Deficient Zika Vector-Based Vaccine Provides Maternal and Fetal Protection in Mouse Model by Gustavo Garcia, Nikhil Chakravarty, Angel Elma Abu, Arjit Vijey Jeyachandran, Kari-Ann Takano, Rebecca Brown, Kouki Morizono, Vaithilingaraja Arumugaswami

Get full text

High-resolution functional profiling of hepatitis C virus genome. by Vaithilingaraja Arumugaswami, Roland Remenyi, Vidhya Kanagavel, Eric Yiang Sue, Tuyet Ngoc Ho, Chang Liu, Vanessa Fontanes, Asim Dasgupta, Ren Sun

Get full text

Differential Susceptibility of Ex Vivo Primary Glioblastoma Tumors to Oncolytic Effect of Modified Zika Virus by Gustavo Garcia, Nikhil Chakravarty, Sophia Paiola, Estrella Urena, Priya Gyani, Christopher Tse, Samuel W. French, Moise Danielpour, Joshua J. Breunig, David A. Nathanson, Vaithilingaraja Arumugaswami

Get full text

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention by Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang

Get full text

Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection by Joseph Ignatius Irudayam, Deisy Contreras, Lindsay Spurka, Aparna Subramanian, Jenieke Allen, Songyang Ren, Vidhya Kanagavel, Quoclinh Nguyen, Arunachalam Ramaiah, Kalidas Ramamoorthy, Samuel W. French, Andrew S. Klein, Vincent Funari, Vaithilingaraja Arumugaswami

Get full text

Differential Susceptibility of Fetal Retinal Pigment Epithelial Cells, hiPSC- Retinal Stem Cells, and Retinal Organoids to Zika Virus Infection by Deisy Contreras, Gustavo Garcia, Melissa Kaye Jones, Laura E. Martinez, Akshaya Jayakarunakaran, Vineela Gangalapudi, Jie Tang, Ying Wu, Jiagang J. Zhao, Zhaohui Chen, Arunachalam Ramaiah, Irena Tsui, Ashok Kumar, Karin Nielsen-Saines, Shaomei Wang, Vaithilingaraja Arumugaswami

Get full text

A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection by Fangyuan Chen, Qingya Shi, Fen Pei, Andreas Vogt, Rebecca A Porritt, Gustavo Garcia, Angela C Gomez, Mary Hongying Cheng, Mark E Schurdak, Bing Liu, Stephen Y Chan, Vaithilingaraja Arumugaswami, Andrew M Stern, D Lansing Taylor, Moshe Arditi, Ivet Bahar

Get full text

The Apolipoprotein E neutralizing antibody inhibits SARS‐CoV‐2 infection by blocking cellular entry of lipoviral particles by Qi Cui, Arjit Vijey Jeyachandran, Gustavo Garcia jr., Chao Qin, Yu Zhou, Mingzi Zhang, Cheng Wang, Guihua Sun, Wei Liu, Tao Zhou, Lizhao Feng, Chance Palmer, Zhuo Li, Adam Aziz, Brigitte N. Gomperts, Pinghui Feng, Vaithilingaraja Arumugaswami, Yanhong Shi

Get full text

A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation by Amelia Palermo, Shen Li, Johanna ten Hoeve, Akshay Chellappa, Alexandra Morris, Barbara Dillon, Feiyang Ma, Yijie Wang, Edward Cao, Byourak Shabane, Rebeca Acín-Perez, Anton Petcherski, A. Jake Lusis, Stanley Hazen, Orian S. Shirihai, Matteo Pellegrini, Vaithilingaraja Arumugaswami, Thomas G. Graeber, Arjun Deb

Get full text

A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry by Anh Phuong Luu, Zhenlan Yao, Sangeetha Ramachandran, Stephanie A. Azzopardi, Linde A. Miles, William M. Schneider, H.-Heinrich Hoffmann, Leonia Bozzacco, Gustavo Garcia, Danyang Gong, Robert Damoiseaux, Hengli Tang, Kouki Morizono, Charles M. Rudin, Ren Sun, Vaithilingaraja Arumugaswami, John T. Poirier, Margaret R. MacDonald, Charles M. Rice, Melody M. H. Li

Get full text

Optimization of a micro-scale air–liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2 by Chandani Sen, Tammy M. Rickabaugh, Arjit Vijey Jeyachandran, Constance Yuen, Maisam Ghannam, Abdo Durra, Adam Aziz, Kristen Castillo, Gustavo Garcia, Arunima Purkayastha, Brandon Han, Felix W. Boulton, Eugene Chekler, Robert Garces, Karen C. Wolff, Laura Riva, Melanie G. Kirkpatrick, Amal Gebara-Lamb, Case W. McNamara, Ulrich A. K. Betz, Vaithilingaraja Arumugaswami, Robert Damoiseaux, Brigitte N. Gomperts

Get full text

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils by Einav Tayeb-Fligelman, Jeannette T. Bowler, Christen E. Tai, Michael R. Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L. Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M. Seidler, Jiahui Lu, Gregory M. Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R. Boyer, Yan Li, Daniel H. Anderson, Kevin A. Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S. Eisenberg

Get full text

The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 by Suan-Sin Foo, Mary Catherine Cambou, Thalia Mok, Viviana M. Fajardo, Kyle L. Jung, Trevon Fuller, Weiqiang Chen, Tara Kerin, Jenny Mei, Debika Bhattacharya, Younho Choi, Xin Wu, Tian Xia, Woo-Jin Shin, Jessica Cranston, Grace Aldrovandi, Nicole Tobin, Deisy Contreras, Francisco J. Ibarrondo, Otto Yang, Shangxin Yang, Omai Garner, Ruth Cortado, Yvonne Bryson, Carla Janzen, Shubhamoy Ghosh, Sherin Devaskar, Brenda Asilnejad, Maria Elisabeth Moreira, Zilton Vasconcelos, Priya R. Soni, L. Caroline Gibson, Patricia Brasil, Suzy A.A. Comhair, Vaithilingaraja Arumugaswami, Serpil C. Erzurum, Rashmi Rao, Jae U. Jung, Karin Nielsen-Saines

Get full text