Influence of macrolide maintenance therapy and bacterial colonisation on exacerbation frequency and progression of COPD (COLUMBUS): Study protocol for a randomised controlled trial by Uzun Sevim, Djamin Remco S, Kluytmans JanAJW, Van’t Veer Nils E, Ermens Anton A M, Pelle Aline J, Mulder Paul, van der Eerden Menno M, Aerts JoachimGJV

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