Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. door Van Voorhis, W, Adams, J, Adelfio, R, Baker, S, Sinden, R

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. door Gelb, M, Van Voorhis, W, Buckner, F, Yokoyama, K, Eastman, R, Carpenter, E, Panethymitaki, C, Brown, K, Smith, D

Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. door Hast, M, Fletcher, S, Cummings, C, Pusateri, E, Blaskovich, M, Rivas, K, Gelb, M, Van Voorhis, W, Sebti, S, Hamilton, A, Beese, L

Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and... door Fletcher, S, Cummings, C, Rivas, K, Katt, W, Hornéy, C, Buckner, F, Chakrabarti, D, Sebti, S, Gelb, M, Van Voorhis, W, Hamilton, A

Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. door Suryadevara, P, Olepu, S, Lockman, J, Ohkanda, J, Karimi, M, Verlinde, C, Kraus, J, Schoepe, J, Van Voorhis, W, Hamilton, A, Buckner, F, Gelb, M

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. door Fletcher, S, Keaney, E, Cummings, C, Blaskovich, M, Hast, M, Glenn, M, Chang, S, Bucher, C, Floyd, R, Katt, W, Gelb, M, Van Voorhis, W, Beese, L, Sebti, S, Hamilton, A

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. door Van Voorhis, W, Rivas, K, Bendale, P, Nallan, L, Hornéy, C, Barrett, L, Bauer, K, Smart, B, Ankala, S, Hucke, O, Verlinde, C, Chakrabarti, D, Strickland, C, Yokoyama, K, Buckner, F, Hamilton, A, Williams, D, Lombardo, L, Floyd, D, Gelb, M

Setting our sights on infectious diseases door De Rycker, M, Horn, D, Aldridge, B, Amewu, RK, Barry, CE, Buckner, FS, Cook, S, Ferguson, MAJ, Gobeau, N, Herrmann, J, Herrling, P, Hope, W, Keiser, J, Lafuente-Monasterio, MJ, Leeson, PD, Leroy, D, Manjunatha, UH, McCarthy, J, Miles, TJ, Mizrahi, V, Moshynets, O, Niles, J, Overington, JP, Pottage, J, Rao, SPS, Read, KD, Ribeiro, I, Silver, LL, Southern, J, Spangenberg, T, Sundar, S, Taylor, C, Van Voorhis, W, White, NJ, Wyllie, S, Wyatt, PG, Gilbert, IH