The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development di Luo, Dahai, Vasudevan, Subhash, Lescar, Julien

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Expression and immunoaffinity purification of recombinant dengue virus 2 NS1 protein as a cleavable SUMOstar fusion di Rozen-Gagnon, Kathryn, Ruedl, Christiane, Moreland, Nicole J., Vasudevan, Subhash G.

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Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity di Saw, Wuan-Geok, Chan, Kitti Wing-Ki, Vasudevan, Subhash G., Grüber, Gerhard

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Dengue virus serotype infection specifies the activation of the unfolded protein response di Chevet Eric, Vasudevan Subhash G, Wang Qing, Pluquet Olivier, Umareddy Indira, Gu Feng

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The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model di Watanabe, Satoru, Tan, Kah Hin, Rathore, Abhay P. S., Rozen-Gagnon, Kathryn, Shuai, Wang, Ruedl, Christiane, Vasudevan, Subhash G.

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Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation di Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng

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Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3 di Phoo, Wint Wint, El Sahili, Abbas, Zhang, ZhenZhen, Chen, Ming Wei, Liew, Chong Wai, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai

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A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication di Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.

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Molecular basis for specific viral RNA recognition and 2' -O-ribose methylation by the dengue virus nonstructural protein 5 (NS5) di Zhao, Yongqian, Soh, Tingjin Sherryl, Lim, Siew Pheng, Chung, Ka Yan, Swaminathan, Kunchithapadam, Vasudevan, Subhash G., Shi, Pei-Yong, Lescar, Julien, Luo, Dahai

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Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin di Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng

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Non-nucleoside inhibitors of Zika virus RNA-dependent RNA polymerase di Gharbi-Ayachi, Aïcha, Santhanakrishnan, Sridhar, Wong, Yee Hwa, Chan, Kitti Wing Ki, Tan, Siok Thing, Bates, Roderick Wayland, Vasudevan, Subhash G., El Sahili, Abbas, Lescar, Julien

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NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication di Swarbrick, Crystall M. D., Basavannacharya, Chandrakala, Chan, Kitti W. K., Chan, Shu-Ann, Singh, Daljit, Wei, Na, Phoo, Wint Wint, Luo, Dahai, Lescar, Julien, Vasudevan, Subhash G.

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Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution di Saw, Wuan Geok, Tria, Giancarlo, Grüber, Ardina, Subramanian Manimekalai, Malathy Sony, Zhao, Yongqian, Chandramohan, Arun, Srinivasan Anand, Ganesh, Matsui, Tsutomu, Weiss, Thomas M., Vasudevan, Subhash G., Grüber, Gerhard

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Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication di Zhao, Yongqian, Soh, Tingjin Sherryl, Chan, Kitti Wing Ki, Fung, Sarah Suet Yin, Swaminathan, Kunchithapadam, Lim, Siew Pheng, Shi, Pei-Yong, Huber, Thomas, Lescar, Julien, Luo, Dahai, Vasudevan, Subhash G.

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The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production di Chan, Kitti W. K., Tay, Moon Y. F., Smith, Kate, Ng, Ivan H. W., Zhao, Yongqian, Ooi, Eng Eong, Lescar, Julien, Luo, Dahai, Jans, David A., Forwood, Jade K., Vasudevan, Subhash G.

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The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication di Tay, Moon Y. F., Saw, Wuan Geok, Zhao, Yongqian, Chan, Kitti W. K., Singh, Daljit, Chong, Yuwen, Forwood, Jade K., Ooi, Eng Eong, Grüber, Gerhard, Lescar, Julien, Luo, Dahai, Vasudevan, Subhash G.

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Cell-active carbazole derivatives as inhibitors of the zika virus protease di Rassias, Gerasimos, Zogali, Vasiliki, Swarbrick, Crystall M. D., Chan, Kitti Wing Ki, Chan, Shu Ann, Gwee, Chin Piaw, Wang, Sai, Kaplanai, Entzy, Canko, Aleksander, Kiousis, Dimitrios, Lescar, Julien, Luo, Dahai, Matsoukas, Minos-Timotheos, Vasudevan, Subhash G.

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A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication di Zhao, Yongqian, Soh, Tingjin Sherryl, Zheng, Jie, Chan, Kitti Wing Ki, Phoo, Wint Wint, Lee, Chin Chin, Tay, Moon Y. F., Swaminathan, Kunchithapadam, Cornvik, Tobias Carl, Lim, Siew Pheng, Shi, Pei-Yong, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai

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Rational engineering and characterization of an mAb that neutralizes Zika virus by targeting a mutationally constrained quaternary epitope di Tharakaraman, Kannan, Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Subramanian, Vidya, Chionh, Yok Hian, Raguram, Aditya, Quinlan, Devin, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Sasisekharan, Ram

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Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope di Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Chionh, Yok Hian, Raguram, Aditya, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Tharakaraman, Kannan, Subramanian, Vidya, Quinlan, Devin Scott, Sasisekharan, Ram

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