Atorvastatin activates skeletal RyR1 channels: towards reducing statin side-effects by Lindsay, C, Venturi, E, Russell, A, Sitsapesan, R

Statins bind to cardiac ryanodine receptor (RyR2) channels to alter opening frequency by Wilson, A, Lindsay, C, Venturi, E, Russell, A, Sitsapesan, R

FKBP12 is a high affinity, reversible activator of RyR2, and FKBP12.6 antagonises its actions by Sitsapesan, R, Pitt, SJ, Venturi, E, Galfre, E, O'Neill, S, Sitsapesan, M

Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2: calcium signaling and excitation–contraction in cardiac, skeletal and smooth muscle by Hu, J, Venturi, E, Sigalas, C, Murayama, T, Nishi, M, Takeshima, H, Sitsapesan, R

Modelling the ATP binding site of RyR2 to rationalise ligand-induced gating behaviour by Lindsay, C, Sitsapesan, M, Chan, WM, Venturi, E, Welch, W, Musgaard, M, Sitsapesan, RM

FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation by Venturi, E, Galfré, E, O'Brien, F, Pitt, SJ, Bellamy, S, Sessions, RB, Sitsapesan, R

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour by Lindsay, C, Sitsapesan, M, Chen, W, Venturi, E, Welch, W, Musgaard, M, Sitsapesan, R

Impaired ligand regulation of native RyR2 channels in the catecholaminergic polymorphic ventricular tachycardia mutation, RyR2-V2475F(+/−) by Wilson, A, Venturi, E, Sigalas, C, Song, Y, Valdivia, C, Valdivia, H, Lei, M, Sitsapesan, R

The malignant hyperthermia G2435R mutation causes constitutive RYR1 openings by Humberstone, TM, Lindsay, C, Wilson, AD, Venturi, E, Alhussni, A, Sigalas, C, Allen, PD, Sitsapesan, RM

TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model. by Venturi, E, Matyjaszkiewicz, A, Pitt, S, Tsaneva-Atanasova, K, Nishi, M, Yamazaki, D, Takeshima, H, Sitsapesan, R

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6. by Galfré, E, Pitt, S, Venturi, E, Sitsapesan, M, Zaccai, N, Tsaneva-Atanasova, K, O'Neill, S, Sitsapesan, R

Cardiac deficiency of P21-activated kinase 1 promotes atrial arrhythmogenesis in mice following adrenergic challenge by Jung, E, Capel, R, Jiang, C, Venturi, E, Neagu, G, Pearcey, S, Zhou, Y, Zhang, Y, Lei, M

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+ by Wilson, AD, Hu, J, Sigalas, C, Venturi, E, Valdivia, HH, Valdivia, CR, Lei, M, Musgaard, M, Sitsapesan, R

Enhanced activity of multiple TRIC‐B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents by O'Brien, F, Eberhardt, D, Witschas, K, El-Ajouz, S, Iida, T, Nishi, M, Takeshima, H, Sitsapesan, R, Venturi, E

Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel by Venturi, E, Mio, K, Nishi, M, Ogura, T, Moriya, T, Pitt, S, Okuda, K, Kakizawa, S, Sitsapesan, R, Sato, C, Takeshima, H

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform by Venturi, E, Lindsay, C, Lotteau, S, Yang, Z, Steer, E, Witschas, K, Wilson, A, Wickens, J, Russell, A, Steele, D, Calaghan, S, Sitsapesan, R

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. by Pitt, S, Funnell, T, Sitsapesan, M, Venturi, E, Rietdorf, K, Ruas, M, Ganesan, A, Gosain, R, Churchill, G, Zhu, M, Parrington, J, Galione, A, Sitsapesan, R

Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A by El-Ajouz, S, Venturi, E, Witschas, K, Beech, M, Wilson, A, Lindsay, C, Eberhardt, D, O'Brien, F, Iida, T, Nishi, M, Takeshima, H, Sitsapesan, R

Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength by Elbaz, M, Ruiz, A, Bachmann, C, Eckhardt, J, Pelczar, P, Venturi, E, Lindsay, C, Wilson, AD, Alhussni, A, Humberstone, T, Pietrangelo, L, Boncompagni, S, Sitsapesan, R, Treves, S, Zorzato, F

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2) by Grieben, M, Pike, A, Shintre, C, Venturi, E, El-Ajouz, S, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N, Sitsapesan, R, Huiskonen, J, Carpenter, E