Colocalization of corneal resistance factor GWAS loci with GTEx e/sQTLs highlights plausible candidate causal genes for keratoconus postnatal corneal stroma weakening by Xinyi Jiang, Xinyi Jiang, Thibaud Boutin, Veronique Vitart

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Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants by Xinyi Jiang, Nefeli Dellepiane, Erola Pairo-Castineira, Thibaud Boutin, Yatendra Kumar, Wendy A. Bickmore, Veronique Vitart

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Electronic health record and genome-wide genetic data in Generation Scotland participants [version 1; referees: 2 approved, 1 approved with reservations] by Shona M. Kerr, Archie Campbell, Jonathan Marten, Veronique Vitart, Andrew M McIntosh, David J. Porteous, Caroline Hayward

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Regional variation in health is predominantly driven by lifestyle rather than genetics by Carmen Amador, Charley Xia, Réka Nagy, Archie Campbell, David Porteous, Blair H. Smith, Nick Hastie, Veronique Vitart, Caroline Hayward, Pau Navarro, Chris S. Haley

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Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation. by Charley Xia, Carmen Amador, Jennifer Huffman, Holly Trochet, Archie Campbell, David Porteous, Generation Scotland, Nicholas D Hastie, Caroline Hayward, Veronique Vitart, Pau Navarro, Chris S Haley

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Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation. by Charley Xia, Carmen Amador, Jennifer Huffman, Holly Trochet, Archie Campbell, David Porteous, Generation Scotland, Nicholas D Hastie, Caroline Hayward, Veronique Vitart, Pau Navarro, Chris S Haley

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Copy number variation across European populations. by Wanting Chen, Caroline Hayward, Alan F Wright, Andrew A Hicks, Veronique Vitart, Sara Knott, Sarah H Wild, Peter P Pramstaller, James F Wilson, Igor Rudan, David J Porteous

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Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping. by Yoshitaka Nagamine, Ricardo Pong-Wong, Pau Navarro, Veronique Vitart, Caroline Hayward, Igor Rudan, Harry Campbell, James Wilson, Sarah Wild, Andrew A Hicks, Peter P Pramstaller, Nicholas Hastie, Alan F Wright, Chris S Haley

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Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions. by Mihail Halachev, Alison Meynert, Martin S Taylor, Veronique Vitart, Shona M Kerr, Lucija Klaric, S. G. P. Consortium, Timothy J Aitman, Chris S Haley, James G Prendergast, Carys Pugh, David A Hume, Sarah E Harris, David C Liewald, Ian J Deary, Colin A Semple, James F Wilson

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Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits. by Andrew D Bretherick, Oriol Canela-Xandri, Peter K Joshi, David W Clark, Konrad Rawlik, Thibaud S Boutin, Yanni Zeng, Carmen Amador, Pau Navarro, Igor Rudan, Alan F Wright, Harry Campbell, Veronique Vitart, Caroline Hayward, James F Wilson, Albert Tenesa, Chris P Ponting, J Kenneth Baillie, Chris Haley

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Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels. by Wilmar Igl, Asa Johansson, James F Wilson, Sarah H Wild, Ozren Polasek, Caroline Hayward, Veronique Vitart, Nicholas Hastie, Pavao Rudan, Carsten Gnewuch, Gerd Schmitz, Thomas Meitinger, Peter P Pramstaller, Andrew A Hicks, Ben A Oostra, Cornelia M van Duijn, Igor Rudan, Alan Wright, Harry Campbell, Ulf Gyllensten, EUROSPAN Consortium

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A multi-omics study of circulating phospholipid markers of blood pressure by Jun Liu, Paul S. de Vries, Fabiola Del Greco M., Åsa Johansson, Katharina E. Schraut, Caroline Hayward, Ko Willems van Dijk, Oscar. H. Franco, Andrew A. Hicks, Veronique Vitart, Igor Rudan, Harry Campbell, Ozren Polašek, Peter P. Pramstaller, James F. Wilson, Ulf Gyllensten, Cornelia M. van Duijn, Abbas Dehghan, Ayşe Demirkan

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Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation. by Gordan Lauc, Abdelkader Essafi, Jennifer E Huffman, Caroline Hayward, Ana Knežević, Jayesh J Kattla, Ozren Polašek, Olga Gornik, Veronique Vitart, Jodie L Abrahams, Maja Pučić, Mislav Novokmet, Irma Redžić, Susan Campbell, Sarah H Wild, Fran Borovečki, Wei Wang, Ivana Kolčić, Lina Zgaga, Ulf Gyllensten, James F Wilson, Alan F Wright, Nicholas D Hastie, Harry Campbell, Pauline M Rudd, Igor Rudan

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DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndrome by Andy Devereux-Cooke, Sian Leary, Simon J. McGrath, Emma Northwood, Anna Redshaw, Charles Shepherd, Pippa Stacey, Claire Tripp, Jim Wilson, Margaret Mar, Danielle Boobyer, Sam Bromiley, Sonya Chowdhury, Claire Dransfield, Mohammed Almas, Øyvind Almelid, David Buchanan, Diana Garcia, John Ireland, Shona M. Kerr, Isabel Lewis, Ewan McDowall, Malgorzata Migdal, Phil Murray, David Perry, Chris P. Ponting, Veronique Vitart, Jareth C. Wolfe

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Typing myalgic encephalomyelitis by infection at onset: A DecodeME study [version 4; peer review: 2 approved] by Andy Devereux-Cooke, Simon J. McGrath, Emma Northwood, Sian Leary, Pippa Stacey, Anna Redshaw, Jim Wilson, Claire Tripp, Isabel Lewis, Sonya Chowdhury, Sumy V. Baby, Øyvind Almelid, Hannes Becher, Tom Baker, Malgorzata Clyde, Thibaud Boutin, John Ireland, Diana Garcia, Ewan McDowall, Shona M. Kerr, Gemma L. Samms, David Perry, Jareth C. Wolfe, Veronique Vitart, Chris P. Ponting, Andrew D. Bretherick

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Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma by Andrew R. Hamel, Wenjun Yan, John M. Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A. Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R. Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P. Khawaja, Stuart MacGregor, International Glaucoma Genetics Consortium (IGGC), Rui Chen, Veronique Vitart, Joshua R. Sanes, Janey L. Wiggs, Ayellet V. Segrè

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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume by Simon Haworth, Chin Yang Shapland, Caroline Hayward, Bram P. Prins, Janine F. Felix, Carolina Medina-Gomez, Fernando Rivadeneira, Carol Wang, Tarunveer S. Ahluwalia, Martine Vrijheid, Mònica Guxens, Jordi Sunyer, Ioanna Tachmazidou, Klaudia Walter, Valentina Iotchkova, Andrew Jackson, Louise Cleal, Jennifer Huffmann, Josine L. Min, Lærke Sass, Paul R. H. J. Timmers, UK10K consortium, George Davey Smith, Simon E. Fisher, James F. Wilson, Tim J. Cole, Dietmar Fernandez-Orth, Klaus Bønnelykke, Hans Bisgaard, Craig E. Pennell, Vincent W. V. Jaddoe, George Dedoussis, Nicholas Timpson, Eleftheria Zeggini, Veronique Vitart, Beate St Pourcain

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Rare variant analyses across multiethnic cohorts identify novel genes for refractive error by Anthony M. Musolf, Annechien E. G. Haarman, Robert N. Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D. Lewis, Milly S. Tedja, Adriana I. Iglesias, Hengtong Li, Cameron S. Cowan, Consortium for Refractive Error and Myopia (CREAM), Ginevra Biino, Alison P. Klein, Priya Duggal, David A. Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Pärssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G. Hysi, Anthony P. Khawaja, Veronique Vitart, Christopher J. Hammond, Cornelia M. van Duijn, Virginie J. M. Verhoeven, Caroline C. W. Klaver, Joan E. Bailey-Wilson

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Genetic determinants of circulating sphingolipid concentrations in European populations. by Andrew A Hicks, Peter P Pramstaller, Asa Johansson, Veronique Vitart, Igor Rudan, Peter Ugocsai, Yurii Aulchenko, Christopher S Franklin, Gerhard Liebisch, Jeanette Erdmann, Inger Jonasson, Irina V Zorkoltseva, Cristian Pattaro, Caroline Hayward, Aaron Isaacs, Christian Hengstenberg, Susan Campbell, Carsten Gnewuch, A Cecilej W Janssens, Anatoly V Kirichenko, Inke R König, Fabio Marroni, Ozren Polasek, Ayse Demirkan, Ivana Kolcic, Christine Schwienbacher, Wilmar Igl, Zrinka Biloglav, Jacqueline C M Witteman, Irene Pichler, Ghazal Zaboli, Tatiana I Axenovich, Annette Peters, Stefan Schreiber, H-Erich Wichmann, Heribert Schunkert, Nick Hastie, Ben A Oostra, Sarah H Wild, Thomas Meitinger, Ulf Gyllensten, Cornelia M van Duijn, James F Wilson, Alan Wright, Gerd Schmitz, Harry Campbell

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Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. by Minerva M Carrasquillo, Olivia Belbin, Olivia Belbin, Fanggeng Zou, Mariet Allen, Nilufer Ertekin-Taner, Morad Ansari, Samantha L Wilcox, Mariah R Kashino, Li Ma, Linda H Younkin, Samuel G Younkin, Curtis S Younkin, Toros A Dincman, Melissa E Howard, Chanley C Howell, Chloe M Stanton, Christopher M Watson, Michael Crump, Veronique Vitart, Caroline Hayward, Nicholas D Hastie, Igor Rudan, Harry Campbell, Ozren Polasek, Kristelle Brown, Peter Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Patrick G Kehoe, David M Mann, A David Smith, Helen Beaumont, Donald Warden, Clive Holmes, Reinhard Heun, Heike Kölsch, Noor Kalsheker, V Shane Pankratz, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Alan F Wright, Steven G Younkin, Kevin Morgan

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