Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse models. by Glen M Boyle, Marjorie M A D'Souza, Carly J Pierce, Ryan A Adams, Aaron S Cantor, Jenny P Johns, Lidia Maslovskaya, Victoria A Gordon, Paul W Reddell, Peter G Parsons

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Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes by Jason K. Cullen, Glen M. Boyle, Pei-Yi Yap, Stefan Elmlinger, Jacinta L. Simmons, Natasa Broit, Jenny Johns, Blake Ferguson, Lidia A. Maslovskaya, Andrei I. Savchenko, Paul Malek Mirzayans, Achim Porzelle, Paul V. Bernhardt, Victoria A. Gordon, Paul W. Reddell, Alberto Pagani, Giovanni Appendino, Peter G. Parsons, Craig M. Williams

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Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade by Kevin Hendrawan, Kelly M Brooks, Pei-Yi Yap, Blake Ferguson, Motoko Koyama, Herlina Handoko, Jenny Johns, Natasa Broit, Praphaporn Stewart, Daniel Shelley, Tracey McMahon, Yi Chieh Lim, Giovanni Appendino, Jason K Cullen, Zara C Bruce, Steven M Ogbourne, Paul W Reddell, Glen M Boyle, Peter G Parsons, Jacinta L Simmons, Emily S Wilson, Marjorie M A de Souza, Tam Hong Nguyen, Alberto Pagani, Victoria A Gordon

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