Autophagy is activated in systemic lupus erythematosus and required for plasmablast development. by Clarke, A, Ellinghaus, U, Cortini, A, Stranks, A, Simon, A, Botto, M, Vyse, T

Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. by Lewis, G, Rapsomaniki, E, Bouriez, T, Crockford, T, Ferry, H, Rigby, R, Vyse, T, Lambe, T, Cornall, R

A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. by Willcocks, L, Carr, E, Niederer, H, Rayner, T, Williams, T, Yang, W, Scott, J, Urban, B, Peshu, N, Vyse, T, Lau, Y, Lyons, P, Smith, K

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model. by Maguire, S, Peck, B, Wai, P, Campbell, J, Barker, H, Gulati, A, Daley, F, Vyse, S, Huang, P, Lord, C, Farnie, G, Brennan, K, Natrajan, R

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus by Oliveira, JJ, Karrar, S, Rainbow, DB, Pinder, CL, Clarke, P, García, A, Al-Assar, O, Burling, K, Morris, S, Stratton, R, Vyse, TJ, Wicker, LS, Todd, JA, Ferreira, R

HLA has strongest association with IgA nephropathy in genome-wide analysis. by Feehally, J, Farrall, M, Boland, A, Gale, D, Gut, I, Heath, S, Kumar, A, Peden, J, Maxwell, P, Morris, D, Padmanabhan, S, Vyse, T, Zawadzka, A, Rees, A, Lathrop, M, Ratcliffe, P

Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in systemic lupus erythematosus by Odhams, C, Roberts, A, Vester, S, Duarte, C, Beales, C, Clarke, A, Lindinger, S, Daffern, S, Zito, A, Chen, L, Jones, L, Boteva, L, Morris, D, Small, K, Fernando, M, Cunninghame Graham, D, Vyse, T

TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues. by Zhang, Z, Gorman, C, Vermi, A, Monaco, C, Foey, A, Owen, S, Amjadi, P, Vallance, A, McClinton, C, Marelli-Berg, F, Isomäki, P, Russell, A, Dazzi, F, Vyse, T, Brennan, F, Cope, A

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression by Ferreira, RC, Dopico, X, Oliveira, JJ, Rainbow, DB, Yang, JH, Trzupek, D, Todd, SA, McNeill, M, Steri, M, Orrù, V, Fiorillo, E, Crouch, DJM, Pekalski, ML, Cucca, F, Tree, TI, Vyse, TJ, Wicker, LS, Todd, JA

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. by Fanciulli, M, Norsworthy, P, Petretto, E, Dong, R, Harper, L, Kamesh, L, Heward, J, Gough, S, de Smith, A, Blakemore, A, Froguel, P, Owen, C, Pearce, S, Teixeira, L, Guillevin, L, Graham, D, Pusey, C, Cook, H, Vyse, T, Aitman, T

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity by Ferreira, R, Simons, H, Thompson, W, Rainbow, D, Yang, X, Cutler, A, Oliveira, J, Castro Dopico, X, Smyth, D, Savinykh, N, Mashar, M, Vyse, T, Dunger, D, Baxendale, H, Chandra, A, Wallace, C, Todd, J, Wicker, L, Pekalski, M

Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. by Aitman, T, Dong, R, Vyse, T, Norsworthy, P, Johnson, MD, Smith, J, Mangion, J, Roberton-Lowe, C, Marshall, A, Petretto, E, Hodges, MD, Bhangal, G, Patel, S, Sheehan-Rooney, K, Duda, M, Cook, P, Evans, D, Domin, J, Flint, J, Boyle, J, Pusey, C, Cook, H

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. by Rioux, J, Goyette, P, Vyse, T, Hammarström, L, Fernando, M, Green, T, De Jager, P, Foisy, S, Wang, J, de Bakker, P, Leslie, S, McVean, G, Padyukov, L, Alfredsson, L, Annese, V, Hafler, D, Pan-Hammarström, Q, Matell, R, Sawcer, S, Compston, A, Cree, B, Mirel, D, Daly, M, Behrens, T, Klareskog, L

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. by de Bakker, P, McVean, G, Sabeti, P, Miretti, M, Green, T, Marchini, J, Ke, X, Monsuur, A, Whittaker, P, Delgado, M, Morrison, J, Richardson, A, Walsh, E, Gao, X, Galver, L, Hart, J, Hafler, D, Pericak-Vance, M, Todd, J, Daly, M, Trowsdale, J, Wijmenga, C, Vyse, T, Beck, S, Murray, S

Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations. by Valdes, A, Styrkarsdottir, U, Doherty, M, Morris, D, Mangino, M, Tamm, A, Doherty, SA, Kisand, K, Kerna, I, Tamm, A, Wheeler, M, Maciewicz, R, Zhang, W, Muir, K, Dennison, E, Hart, D, Metrustry, S, Jonsdottir, I, Jonsson, G, Jonsson, H, Ingvarsson, T, Cooper, C, Vyse, T, Spector, T, Stefansson, K, Arden, N

Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE). by Hellquist, A, Zucchelli, M, Lindgren, C, Saarialho-Kere, U, Järvinen, T, Koskenmies, S, Julkunen, H, Onkamo, P, Skoog, T, Panelius, J, Räisänen-Sokolowski, A, Hasan, T, Widen, E, Gunnarson, I, Svenungsson, E, Padyukov, L, Assadi, G, Berglind, L, Mäkelä, V, Kivinen, K, Wong, A, Cunningham Graham, D, Vyse, T, D'Amato, M, Kere, J

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders. by Taylor, J, Martin, H, Lise, S, Broxholme, J, Cazier, J, Rimmer, A, Kanapin, A, Lunter, G, Fiddy, S, Allan, C, Aricescu, A, Attar, M, Babbs, C, Becq, J, Beeson, D, Bento, C, Bignell, P, Blair, E, Buckle, V, Bull, K, Cais, O, Cario, H, Chapel, H, Copley, R, Cornall, R, Craft, J, Dahan, K, Davenport, E, Dendrou, C, Devuyst, O, Fenwick, A, Flint, J, Fugger, L, Gilbert, R, Goriely, A, Green, A, Greger, I, Grocock, R, Gruszczyk, A, Hastings, R, Hatton, E, Higgs, D, Hill, A, Holmes, C, Howard, M, Hughes, L, Humburg, P, Johnson, D, Karpe, F, Kingsbury, Z, Kini, U, Knight, J, Krohn, J, Lamble, S, Langman, C, Lonie, L, Luck, J, McCarthy, D, McGowan, S, McMullin, M, Miller, K, Murray, L, Németh, A, Nesbit, A, Nutt, D, Ormondroyd, E, Oturai, A, Pagnamenta, A, Patel, S, Percy, M, Petousi, N, Piazza, P, Piret, S, Polanco-Echeverry, G, Popitsch, N, Powrie, F, Pugh, C, Quek, L, Robbins, P, Robson, K, Russo, A, Sahgal, N, van Schouwenburg, P, Schuh, A, Silverman, E, Simmons, A, Sørensen, P, Sweeney, E, Taylor, J, Thakker, R, Tomlinson, I, Trebes, A, Twigg, S, Uhlig, H, Vyas, P, Vyse, T, Wall, S, Watkins, H, Whyte, M, Witty, L, Wright, B, Yau, C, Buck, D, Humphray, S, Ratcliffe, P, Bell, J, Wilkie, A, Bentley, D, Donnelly, P, McVean, G