Wellcome Trust Case Control Consortium
The Wellcome Trust Case Control Consortium (abbreviated WTCCC) is a collaboration between fifty research groups in the United Kingdom in the field of human genetics. Established in 2005, the WTCCC aims to conduct genome-wide association studies (GWASs) to shed light on the genetic architecture of common human diseases. The founding chairman of the consortium was University of Oxford statistician Peter Donnelly. The consortium was funded by £9 million from the Wellcome Trust. According to the consortium's website, it has identified "approximately 90" new susceptibility loci for common human diseases.The consortium's initial goal was to conduct large GWASs for eight common human diseases: tuberculosis, coronary heart disease, type 1 diabetes, type 2 diabetes, rheumatoid arthritis, Crohn's disease and ulcerative colitis, bipolar disorder and hypertension. These GWASs included a total of 19,000 subjects, of whom 2,000 had one of the eight diseases and an additional 3,000 served as controls. The study participants were genotyped using Affymetrix's GeneChip Human Mapping 500K Array Set, and genotype calling was conducted with the Chiamo algorithm.
The results of the WTCCC's initial research were reported in ''Nature'' in 2007. The research identified 24 genetic association "signals" that were statistically significant at ''P'' < 5 × 10−7. At the time, this was the largest study ever conducted of the genetics of human diseases. In announcing the study's findings at a London news conference, Donnelly said, "If you think of the genome as a very long road that you are trying to find your way along in the dark, previously we have only been able to turn lights on in a small number of places, but now we can turn on lights in a large number of places— in this case half a million lights". The 2007 ''Nature'' paper was later named "paper of the year" by ''the Lancet'', and it led to the WTCCC being named "research leader of the year" by ''Scientific American''. Provided by Wikipedia
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Genome-wide association data highlight an aetiological role for disturbances in cyclin-dependent kinase pathways in type 2 diabetes by Timpson, N, Zeggini, E, Weedon, M, Lingdren, C, Frayling, T, Elliott, K, Lango, H, Perry, J, Rayner, N, Freathy, R, Barret, J, Groves, C, Morris, A, Hattersley, A, McCarthy, M, Consort, U, WTCCC
Published 2007Conference item -
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Large-scale replication typing of modest signals from genome-wide association studies identifies additional type 2 diabetes susceptibility variants in the IGF2BP2 and VEGFA genes by Zeggini, E, Weedon, M, Lindgren, C, Frayling, T, Elliott, K, Lango, H, Timpson, N, Perry, J, Rayner, N, Freathy, R, Barrett, J, Groves, C, Morris, A, Hattersley, A, McCarthy, M, Consort, U, WTCCC
Published 2007Conference item -
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Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. by Blue Mountains Eye Study (BMES), Wellcome Trust Case Control Consortium 2 (WTCCC2), Strange, A, Bellenguez, C, Freeman, C, Pirinen, M, Su, Z, Band, G, Pearson, R, Vukcevic, D, Rautanen, A, Spencer, C, Donnelly, P
Published 2013Journal article -
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A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains by Ranlund, S, Calafato, S, Thygesen, JH, Lin, K, Cahn, W, Crespo-Facorro, B, De Zwarte, SMC, Díez, Á, Di Forti, M, Group, Iyegbe, C, Jablensky, A, Jones, R, Hall, M-H, Kahn, R, Kalaydjieva, L, Kravariti, E, McDonald, C, McIntosh, AM, McQuillin, A, Peic, Picchioni, M, Prata, DP, Rujescu, D, Schulze, K, Shaikh, M, Toulopoulou, T, Van Haren, N, Van Os, J, Vassos, E, Walshe, M, Wtccc2, Lewis, C, Murray, RM, Powell, J, Bramon, E
Published 2017Journal article -
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Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders by Calafato, MS, Thygesen, JH, Ranlund, S, Zartaloudi, E, Cahn, W, Crespo-Facorro, B, Díez-Revuelta, Á, Di Forti, M, Genetic Risk And Outcome Of Psychosis (Group) Consortium, Hall, M-H, Iyegbe, C, Jablensky, A, Kahn, R, Kalaydjieva, L, Kravariti, E, Lin, K, McDonald, C, McIntosh, AM, McQuillin, A, Psychosis Endophenotypes International Consortium (PEIC), Picchioni, M, Rujescu, D, Shaikh, M, Toulopoulou, T, Os, JV, Vassos, E, Walshe, M, Powell, J, Lewis, CM, Murray, RM, Bramon, E, Wellcome Trust Case Control Consortium 2 (WTCCC2)
Published 2018Journal article -
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A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. by Matthew Traylor, Kari-Matti Mäkelä, Laura L Kilarski, Elizabeth G Holliday, William J Devan, Mike A Nalls, Kerri L Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2), Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M Maguire, Matthew Walters, Ale Algra, Pankaj Sharma, John R Attia, Giorgio B Boncoraglio, Peter M Rothwell, Paul I W de Bakker, Joshua C Bis, Danish Saleheen, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, James F Meschia, Christopher Levi, Martin Dichgans, Terho Lehtimäki, Cathryn M Lewis, Hugh S Markus
Published 2014-07-01
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DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia by Eilis Hannon, Emma L Dempster, Georgina Mansell, Joe Burrage, Nick Bass, Marc M Bohlken, Aiden Corvin, Charles J Curtis, David Dempster, Marta Di Forti, Timothy G Dinan, Gary Donohoe, Fiona Gaughran, Michael Gill, Amy Gillespie, Cerisse Gunasinghe, Hilleke E Hulshoff, Christina M Hultman, Viktoria Johansson, René S Kahn, Jaakko Kaprio, Gunter Kenis, Kaarina Kowalec, James MacCabe, Colm McDonald, Andrew McQuillin, Derek W Morris, Kieran C Murphy, Colette J Mustard, Igor Nenadic, Michael C O'Donovan, Diego Quattrone, Alexander L Richards, Bart PF Rutten, David St Clair, Sebastian Therman, Timothea Toulopoulou, Jim Van Os, John L Waddington, Wellcome Trust Case Control Consortium (WTCCC), CRESTAR consortium, Patrick Sullivan, Evangelos Vassos, Gerome Breen, David Andrew Collier, Robin M Murray, Leonard S Schalkwyk, Jonathan Mill
Published 2021-02-01
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Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases by Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Höhn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE, Li, X, Yazar, S, Nag, A, Khawaja, AP, Polašek, O, Siscovick, D, Mitchell, P, Tham, YC, Haines, JL, Kearns, LS, Hayward, C, Shi, Y, Van Leeuwen, EM, Taylor, KD, Blue Mountains Eye Study - Gwas Group, Bonnemaijer, P, Rotter, JI, Martin, NG, Zeller, T, Mills, RA, Souzeau, E, Staffieri, SE, Jonas, JB, Schmidtmann, I, Boutin, T, Kang, JH, Lucas, SEM, Wong, TY, Beutel, ME, Wilson, JF, Wellcome Trust Case Control Consortium 2 (Wtccc2), Neighborhood Consortium, Uitterlinden, AG, Vithana, EN, Foster, PJ, Hysi, PG, Hewitt, AW, Khor, CC, Pasquale, LR, Montgomery, GW, Klaver, CCW, Aung, T, Pfeiffer, N, Mackey, DA, Hammond, CJ, Cheng, C-Y, Craig, JE, Rabinowitz, YS, Wiggs, JL, Burdon, KP, Van Duijn, CM, Macgregor, S
Published 2019Journal article -
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Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke by Cole, J, Xu, H, Ryan, K, Jaworek, T, Dueker, N, McArdle, P, Gaynor, B, Cheng, Y, O'Connell, J, Bevan, S, Malik, R, Ahmed, N, Amouyel, P, Anjum, S, Bis, J, Crosslin, D, Danesh, J, Engelter, S, Fornage, M, Frossard, P, Gieger, C, Giese, A, Grond-Ginsbach, C, Ho, W, Holliday, E, Hopewell, J, Hussain, M, Iqbal, W, Jabeen, S, Jannes, J, Kamal, A, Kamatani, Y, Kanse, S, Kloss, M, Lathrop, M, Leys, D, Lindgren, A, Longstreth, W, Mahmood, K, Meisinger, C, Metso, T, Mosley, T, Müller-Nurasyid, M, Norrving, B, Parati, E, Peters, A, Pezzini, A, Quereshi, I, Rasheed, A, Rauf, A, Salam, T, Shen, J, Słowik, A, Stanne, T, Strauch, K, Tatlisumak, T, Thijs, V, Tiedt, S, Traylor, M, Waldenberger, M, Walters, M, Zhao, W, Boncoraglio, G, Debette, S, Jern, C, Levi, C, Markus, H, Meschia, J, Rolfs, A, Rothwell, P, Saleheen, D, Seshadri, S, Sharma, P, Sudlow, C, Worrall, B, Metastroke Consortium Of The Isgc, Wtccc-2 Consortium, Stine, O, Kittner, S, Mitchell, B
Published 2018Journal article -
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Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis. by Gharahkhani, P, Fitzgerald, R, Vaughan, T, Palles, C, Gockel, I, Tomlinson, I, Buas, M, May, A, Gerges, C, Anders, M, Becker, J, Kreuser, N, Noder, T, Venerito, M, Veits, L, Schmidt, T, Manner, H, Schmidt, C, Hess, T, Böhmer, A, Izbicki, J, Hölscher, A, Lang, H, Lorenz, D, Schumacher, B, Hackelsberger, A, Mayershofer, R, Pech, O, Vashist, Y, Ott, K, Vieth, M, Weismüller, J, Nöthen, M, Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), Esophageal Adenocarcinoma GenEtics Consortium (EAGLE), Wellcome Trust Case Control Consortium 2 (WTCCC2), Attwood, S, Barr, H, Chegwidden, L, de Caestecker, J, Harrison, R, Love, S, MacDonald, D, Moayyedi, P, Prenen, H, Watson, R, Iyer, P, Anderson, L, Bernstein, L, Chow, W, Hardie, L, Lagergren, J, Liu, G, Risch, H, Wu, A, Ye, W, Bird, N, Shaheen, N, Gammon, M, Corley, D, Caldas, C, Moebus, S, Knapp, M, Peters, W, Neuhaus, H, Rösch, T, Ell, C, MacGregor, S, Pharoah, P, Whiteman, D, Jankowski, J, Schumacher, J
Published 2016Journal article -
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A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease by Plagnol, V, Nalls, M, Bras, J, Hernandez, D, Sharma, M, Sheerin, U, Saad, M, Simon-Sanchez, J, Schulte, C, Lesage, S, Sveinbjornsdottir, S, Amouyel, P, Arepalli, S, Band, G, Barker, R, Bellinguez, C, Ben-Shlomo, Y, Berendse, H, Berg, D, Bhatia, K, de Bie, R, Biffi, A, Bloem, B, Bochdanovits, Z, Bonin, M, Brockmann, K, Brooks, J, Burn, D, Charlesworth, G, Chen, H, Chinnery, P, Chong, S, Clarke, C, Cookson, MR, Cooper, J, Corvol, J, Counsell, C, Damier, P, Dartigues, J, Deloukas, P, Deuschl, G, Dexter, D, van Dijk, K, Dillman, A, Durif, F, Duerr, A, Edkins, S, Evans, JR, Foltynie, T, Freeman, C, Gao, J, Gardner, M, Gibbs, JR, Goate, A, Gray, E, Guerreiro, R, Gustafsson, O, Harris, C, Hellenthal, G, van Hilten, J, Hofman, A, Hollenbeck, A, Holton, J, Hu, M, Huang, X, Huber, H, Hudson, G, Hunt, SE, Huttenlocher, J, Illig, T, Jonsson, P, Langford, C, Lees, A, Lichtner, P, Limousin, P, Lopez, G, Lorenz, D, McNeill, A, Moorby, C, Moore, M, Morris, H, Morrison, K, Mudanohwo, E, O'Sullivan, S, Pearson, J, Pearson, R, Perlmutter, J, Petursson, H, Pirinen, M, Pollak, P, Post, B, Potter, S, Ravina, B, Revesz, T, Riess, O, Rivadeneira, F, Rizzu, P, Ryten, M, Sawcer, S, Schapira, A, Scheffer, H, Shaw, K, Shoulson, I, Sidransky, E, de Silva, R, Smith, C, Spencer, C, Stefansson, H, Steinberg, S, Stockton, J, Strange, A, Su, Z, Talbot, K, Tanner, C, Tashakkori-Ghanbaria, A, Tison, F, Trabzuni, D, Traynor, B, Uitterlinden, A, Vandrovcova, J, Velseboer, D, Vidailhet, M, Vukcevic, D, Walker, R, van de Warrenburg, B, Weale, M, Wickremaratchi, M, Williams, N, Williams-Gray, C, Winder-Rhodes, S, Stefansson, K, Martinez, M, Donnelly, P, Singleton, AB, Hardy, J, Heutink, P, Brice, A, Gasser, T, Wood, N, WTCCC2
Published 2011Journal article