High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer by Sarah E. Pierce, Jeffrey M. Granja, William J. Greenleaf

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Protocol for mapping the three-dimensional organization of dinoflagellate genomes by Georgi K. Marinov, Anshul Kundaje, William J. Greenleaf, Arthur R. Grossman

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Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme by Johan O. L. Andreasson, Andrew Savinov, Steven M. Block, William J. Greenleaf

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An optimized ATAC-seq protocol for genome-wide mapping of active regulatory elements in primary mouse cortical neurons by Maya Maor-Nof, Zohar Shipony, Georgi K. Marinov, William J. Greenleaf, Aaron D. Gitler

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The chromatin landscape of the euryarchaeon Haloferax volcanii by Georgi K. Marinov, S. Tansu Bagdatli, Tong Wu, Chuan He, Anshul Kundaje, William J. Greenleaf

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Global mapping of RNA-chromatin contacts reveals a proximity-dominated connectivity model for ncRNA-gene interactions by Charles Limouse, Owen K. Smith, David Jukam, Kelsey A. Fryer, William J. Greenleaf, Aaron F. Straight

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Generation of a dual edited human induced pluripotent stem cell Myl7-GFP reporter line with inducible CRISPRi/dCas9 by Eyal Metzl-Raz, Nike Bharucha, Jennifer Arthur Ataam, Alexandra A. Gavidia, William J. Greenleaf, Ioannis Karakikes

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Unsupervised clustering and epigenetic classification of single cells by Mahdi Zamanighomi, Zhixiang Lin, Timothy Daley, Xi Chen, Zhana Duren, Alicia Schep, William J. Greenleaf, Wing Hung Wong

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INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division by Graeme J. Gowans, Alicia N. Schep, Ka Man Wong, Devin A. King, William J. Greenleaf, Ashby J. Morrison

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Reduced chromatin accessibility to CD4 T cell super-enhancers encompassing susceptibility loci of rheumatoid arthritis by Rohit R. Jadhav, Bin Hu, Zhongde Ye, Khushboo Sheth, Xuanying Li, William J. Greenleaf, Cornelia M. Weyand, Jörg J. Goronzy

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A comprehensive thermodynamic model for RNA binding by the Saccharomyces cerevisiae Pumilio protein PUF4 by Christoph Sadée, Lauren D. Hagler, Winston R. Becker, Inga Jarmoskaite, Pavanapuresan P. Vaidyanathan, Sarah K. Denny, William J. Greenleaf, Daniel Herschlag

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Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity by Xingqi Chen, Ulrike M. Litzenburger, Yuning Wei, Alicia N. Schep, Edward L. LaGory, Hani Choudhry, Amato J. Giaccia, William J. Greenleaf, Howard Y. Chang

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Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions by Rajarshi P. Ghosh, Quanming Shi, Linfeng Yang, Michael P. Reddick, Tatiana Nikitina, Victor B. Zhurkin, Polly Fordyce, Timothy J. Stasevich, Howard Y. Chang, William J. Greenleaf, Jan T. Liphardt

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CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping by Georgi K. Marinov, Samuel H. Kim, S. Tansu Bagdatli, Soon Il Higashino, Alexandro E. Trevino, Josh Tycko, Tong Wu, Lacramioara Bintu, Michael C. Bassik, Chuan He, Anshul Kundaje, William J. Greenleaf

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A Conditional System to Specifically Link Disruption of Protein-Coding Function with Reporter Expression in Mice by Shin-Heng Chiou, Caroline Kim-Kiselak, Viviana I. Risca, Megan K. Heimann, Chen-Hua Chuang, Aurora A. Burds, William J. Greenleaf, Tyler E. Jacks, David M. Feldser, Monte M. Winslow

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Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements by Josh Tycko, Michael Wainberg, Georgi K. Marinov, Oana Ursu, Gaelen T. Hess, Braeden K. Ego, Aradhana, Amy Li, Alisa Truong, Alexandro E. Trevino, Kaitlyn Spees, David Yao, Irene M. Kaplow, Peyton G. Greenside, David W. Morgens, Douglas H. Phanstiel, Michael P. Snyder, Lacramioara Bintu, William J. Greenleaf, Anshul Kundaje, Michael C. Bassik

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