Going beyond genetics to discover cancer targets by Gabriel J. Sandoval, William C. Hahn

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RMRP is a non-coding RNA essential for early murine development. by Joseph Rosenbluh, Deepak Nijhawan, Zhao Chen, Kwok-Kin Wong, Kenkichi Masutomi, William C Hahn

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Structural basis of PP2A inhibition by small t antigen. by Uhn Soo Cho, Seamus Morrone, Anna A Sablina, Jason D Arroyo, William C Hahn, Wenqing Xu

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IKK∊-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase Complex by Alicia Y. Zhou, Rhine R. Shen, Eejung Kim, Ying J. Lock, Ming Xu, Zhijian J. Chen, William C. Hahn

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Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects by Joshua M. Dempster, Isabella Boyle, Francisca Vazquez, David E. Root, Jesse S. Boehm, William C. Hahn, Aviad Tsherniak, James M. McFarland

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High throughput interrogation of somatic mutations in high grade serous cancer of the ovary. by Ursula A Matulonis, Michelle Hirsch, Emanuele Palescandolo, Eejung Kim, Joyce Liu, Paul van Hummelen, Laura MacConaill, Ronny Drapkin, William C Hahn

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Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma by Simone Hettmer, Anna C Schinzel, Daria Tchessalova, Michaela Schneider, Christina L Parker, Roderick T Bronson, Nigel GJ Richards, William C Hahn, Amy J Wagers

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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. by Heidi Greulich, Tzu-Hsiu Chen, Whei Feng, Pasi A Jänne, James V Alvarez, Mauro Zappaterra, Sara E Bulmer, David A Frank, William C Hahn, William R Sellers, Matthew Meyerson

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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. by Ron Firestein, Gil Blander, Shaday Michan, Philipp Oberdoerffer, Shuji Ogino, Jennifer Campbell, Anupama Bhimavarapu, Sandra Luikenhuis, Rafael de Cabo, Charles Fuchs, William C Hahn, Leonard P Guarente, David A Sinclair

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An Atlas of Variant Effects to understand the genome at nucleotide resolution by Douglas M. Fowler, David J. Adams, Anna L. Gloyn, William C. Hahn, Debora S. Marks, Lara A. Muffley, James T. Neal, Frederick P. Roth, Alan F. Rubin, Lea M. Starita, Matthew E. Hurles

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Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal by J. Michael Krill-Burger, Joshua M. Dempster, Ashir A. Borah, Brenton R. Paolella, David E. Root, Todd R. Golub, Jesse S. Boehm, William C. Hahn, James M. McFarland, Francisca Vazquez, Aviad Tsherniak

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CK1epsilon is required for breast cancers dependent on beta-catenin activity. by So Young Kim, Ian F Dunn, Ron Firestein, Piyush Gupta, Leslie Wardwell, Kara Repich, Anna C Schinzel, Ben Wittner, Serena J Silver, David E Root, Jesse S Boehm, Sridhar Ramaswamy, Eric S Lander, William C Hahn

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BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. by Joseph H Jeong, Zhenxiong Wang, Alexander S Guimaraes, Xuesong Ouyang, Jose L Figueiredo, Zhihu Ding, Shan Jiang, Isil Guney, Gyeong Hoon Kang, Eyoung Shin, William C Hahn, Massimo F Loda, Cory Abate-Shen, Ralph Weissleder, Lynda Chin

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Analysis and comparison of somatic mutations in paired primary and recurrent epithelial ovarian cancer samples. by Yong-Man Kim, Shin-Wha Lee, Sung-Min Chun, Dae-Yeon Kim, Jong-Hyeok Kim, Kyu-Rae Kim, Young-Tak Kim, Joo-Hyun Nam, Paul van Hummelen, Laura E MacConaill, William C Hahn, Se Jin Jang

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PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA by Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C. Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price, David M. Weinstock

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PTK6 regulates IGF-1-induced anchorage-independent survival. by Hanna Y Irie, Yashaswi Shrestha, Laura M Selfors, Fabianne Frye, Naoko Iida, Zhigang Wang, Lihua Zou, Jun Yao, Yiling Lu, Charles B Epstein, Sridaran Natesan, Andrea L Richardson, Kornelia Polyak, Gordon B Mills, William C Hahn, Joan S Brugge

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Mapping the landscape of genetic dependencies in chordoma by Tanaz Sharifnia, Mathias J. Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M. Dempster, Sandrine Muller, Joan Levy, Daniel M. Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C. Hahn, David E. Root, Paul A. Clemons, Stuart L. Schreiber

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Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells by Hugh S. Gannon, Tao Zou, Michael K. Kiessling, Galen F. Gao, Diana Cai, Peter S. Choi, Alexandru P. Ivan, Ilana Buchumenski, Ashton C. Berger, Jonathan T. Goldstein, Andrew D. Cherniack, Francisca Vazquez, Aviad Tsherniak, Erez Y. Levanon, William C. Hahn, Matthew Meyerson

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STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells by Jong Wook Kim, Christian Berrios, Miju Kim, Amy E Schade, Guillaume Adelmant, Huwate Yeerna, Emily Damato, Amanda Balboni Iniguez, Laurence Florens, Michael P Washburn, Kim Stegmaier, Nathanael S Gray, Pablo Tamayo, Ole Gjoerup, Jarrod A Marto, James DeCaprio, William C Hahn

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BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors by Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aaron Ross, Francisca Vazquez, William C. Hahn, Peter J. Park, Charles W. M. Roberts

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