P637: TIME-LIMITED TREATMENT WITH ACALABRUTINIB PLUS OBINUTUZUMAB IN TREATMENT-NAÏVE CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: EARLY RESULTS OF AN ONGOING PHASE 2 TRIAL by Jan Burger, Ekaterina Kim, Mariela Sivina, Ghayas Issa, Philip Thompson, William G. Wierda, Alessandra Ferrajoli

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Regulation of Mcl-1 Expression in Context to Bone Marrow Stromal Microenvironment in Chronic Lymphocytic Leukemia by Kumudha Balakrishnan, PhD, Jan A. Burger, Min Fu, Tejaswini Doifode, William G. Wierda, Varsha Gandhi

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The TKI Era in Chronic Leukemias by Danilo De Novellis, Fabiana Cacace, Valeria Caprioli, William G. Wierda, Kris M. Mahadeo, Francesco Paolo Tambaro

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Vecabrutinib inhibits B-cell receptor signal transduction in chronic lymphocytic leukemia cell types with wild-type or mutant Bruton tyrosine kinase by Burcu Aslan, Stefan Edward Hubner, Judith A. Fox, Pietro Taverna, William G. Wierda, Steven M. Kornblau, Varsha Gandhi

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Global miRNA profiling reveals key molecules that contribute to different chronic lymphocytic leukemia incidences in Asian and Western populations by Panpan Liu, Kefeng Wang, Jianan Li, Marcia A. Ogasawara, Zhongjun Xia, William G. Wierda, Michael J. Keating, Yiqing Li, Peng Huang

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Monitoring and Managing BTK Inhibitor Treatment-Related Adverse Events in Clinical Practice by Susan M. O’Brien, Jennifer R. Brown, John C. Byrd, Richard R. Furman, Paolo Ghia, Jeff P. Sharman, William G. Wierda

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Consolidation treatment with lenalidomide following front-line or salvage chemoimmunotherapy in chronic lymphocytic leukemia by Paolo Strati, Michael J. Keating, Jan A. Burger, Susan M. O’Brien, William G. Wierda, Zeev Estrov, Gracy Zacharian, Alessandra Ferrajoli

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Transcriptomic clustering of chronic lymphocytic leukemia: molecular subtypes based on Bruton’s tyrosine kinase expression levels by Gorkem Kismali, Ganiraju Manyam, Nitin Jain, Cristina Ivan, Betty Lamothe, Mary L. Ayres, LaKesla R. Iles, William G. Wierda, Varsha Gandhi

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The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells by Hima V. Vangapandu, Mary L. Ayres, Christopher A. Bristow, William G. Wierda, Michael J. Keating, Kumudha Balakrishnan, Christine M. Stellrecht, Varsha Gandhi

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Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion by Paolo Strati, Michael J. Keating, Susan M. O’Brien, Alessandra Ferrajoli, Jan Burger, Stefan Faderl, Francesco Paolo Tambaro, Nitin Jain, William G. Wierda

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A review of the incidence of tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with venetoclax and debulking strategies by Jeffrey P. Sharman, Juliana M. L. Biondo, Michelle Boyer, Kirsten Fischer, Michael Hallek, Dingfeng Jiang, Arnon P. Kater, Michele Porro Lurà, William G. Wierda

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Pirtobrutinib inhibits wild-type and mutant Bruton’s tyrosine kinase-mediated signaling in chronic lymphocytic leukemia by Burcu Aslan, Gorkem Kismali, Lakesla R. Iles, Ganiraju C. Manyam, Mary L. Ayres, Lisa S. Chen, Mihai Gagea, Maria Teresa Sabrina Bertilaccio, William G. Wierda, Varsha Gandhi

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High-Risk Acute Myeloid Leukemia: A Pediatric Prospective by Fabiana Cacace, Rossella Iula, Danilo De Novellis, Valeria Caprioli, Maria Rosaria D’Amico, Giuseppina De Simone, Rosanna Cuccurullo, William G. Wierda, Kris Michael Mahadeo, Giuseppe Menna, Francesco Paolo Tambaro

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P617: FIXED-DURATION (FD) IBRUTINIB + VENETOCLAX FOR FIRST-LINE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)/SMALL LYMPHOCYTIC LYMPHOMA (SLL): 4-Y FOLLOW-UP FROM FD COHORT OF PH... by Paolo Ghia, John Allan, Tanya Siddiqi, William G. Wierda, Constantine Tam, Carol Moreno, Alessandra Tedeschi, Edith Szafer-Glusman, Cathy Zhou, Chris Abbazio, Jim Dean, Anita Szoke, Paul M. Barr

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Autoimmune cytopenias in patients with chronic lymphocytic leukemia treated with ibrutinib by Candida Vitale, Inhye E. Ahn, Mariela Sivina, Alessandra Ferrajoli, William G. Wierda, Zeev Estrov, Sergej N. Konoplev, Nitin Jain, Susan O’Brien, Mohammed Farooqui, Michael J. Keating, Adrian Wiestner, Jan A. Burger

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A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. by Carmen D Schweighofer, Kevin R Coombes, Lynn L Barron, Lixia Diao, Rachel J Newman, Alessandra Ferrajoli, Susan O'Brien, William G Wierda, Rajyalakshmi Luthra, L Jeffrey Medeiros, Michael J Keating, Lynne V Abruzzo

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Calreticulin as a novel B-cell receptor antigen in chronic lymphocytic leukemia by Elisa ten Hacken, Maria Gounari, Jaap Willem Back, Ekaterina Shimanovskaya, Lydia Scarfò, Ekaterina Kim, Jared Burks, Maurilio Ponzoni, Giuseppe Alvise Ramirez, William G. Wierda, Zeev Estrov, Michael J. Keating, Alessandra Ferrajoli, Kostas Stamatopoulos, Paolo Ghia, Jan A. Burger

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The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells. by Stefania Fiorcari, Wells S Brown, Bradley W McIntyre, Zeev Estrov, Rossana Maffei, Susan O'Brien, Mariela Sivina, Julia Hoellenriegel, William G Wierda, Michael J Keating, Wei Ding, Neil E Kay, Brian J Lannutti, Roberto Marasca, Jan A Burger

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Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations. by Drew C Deniger, Jianqiang Yu, M Helen Huls, Matthew J Figliola, Tiejuan Mi, Sourindra N Maiti, George F Widhopf, Lenka V Hurton, Radhika Thokala, Harjeet Singh, Simon Olivares, Richard E Champlin, William G Wierda, Thomas J Kipps, Laurence J N Cooper

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Utility of positron emission tomography-computed tomography in patients with chronic lymphocytic leukemia following B-cell receptor pathway inhibitor therapy by Anthony R. Mato, William G. Wierda, Matthew S. Davids, Bruce D. Cheson, Steven E. Coutre, Michael Choi, Richard R. Furman, Leonard Heffner, Paul M. Barr, Herbert Eradat, Sharanya M. Ford, Lang Zhou, Maria Verdugo, Rod A. Humerickhouse, Jalaja Potluri, John C. Byrd

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