P637: TIME-LIMITED TREATMENT WITH ACALABRUTINIB PLUS OBINUTUZUMAB IN TREATMENT-NAÏVE CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: EARLY RESULTS OF AN ONGOING PHASE 2 TRIAL by Jan Burger, Ekaterina Kim, Mariela Sivina, Ghayas Issa, Philip Thompson, William G. Wierda, Alessandra Ferrajoli

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The TKI Era in Chronic Leukemias by Danilo De Novellis, Fabiana Cacace, Valeria Caprioli, William G. Wierda, Kris M. Mahadeo, Francesco Paolo Tambaro

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Monitoring and Managing BTK Inhibitor Treatment-Related Adverse Events in Clinical Practice by Susan M. O’Brien, Jennifer R. Brown, John C. Byrd, Richard R. Furman, Paolo Ghia, Jeff P. Sharman, William G. Wierda

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The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells by Hima V. Vangapandu, Mary L. Ayres, Christopher A. Bristow, William G. Wierda, Michael J. Keating, Kumudha Balakrishnan, Christine M. Stellrecht, Varsha Gandhi

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A review of the incidence of tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with venetoclax and debulking strategies by Jeffrey P. Sharman, Juliana M. L. Biondo, Michelle Boyer, Kirsten Fischer, Michael Hallek, Dingfeng Jiang, Arnon P. Kater, Michele Porro Lurà, William G. Wierda

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Pirtobrutinib inhibits wild-type and mutant Bruton’s tyrosine kinase-mediated signaling in chronic lymphocytic leukemia by Burcu Aslan, Gorkem Kismali, Lakesla R. Iles, Ganiraju C. Manyam, Mary L. Ayres, Lisa S. Chen, Mihai Gagea, Maria Teresa Sabrina Bertilaccio, William G. Wierda, Varsha Gandhi

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Selection of a Nuclease-Resistant RNA Aptamer Targeting CD19 by Carla L. Esposito, Katrien Van Roosbroeck, Gianluca Santamaria, Deborah Rotoli, Annamaria Sandomenico, William G. Wierda, Alessandra Ferrajoli, Menotti Ruvo, George A. Calin, Vittorio de Franciscis, Silvia Catuogno

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High-Risk Acute Myeloid Leukemia: A Pediatric Prospective by Fabiana Cacace, Rossella Iula, Danilo De Novellis, Valeria Caprioli, Maria Rosaria D’Amico, Giuseppina De Simone, Rosanna Cuccurullo, William G. Wierda, Kris Michael Mahadeo, Giuseppe Menna, Francesco Paolo Tambaro

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P617: FIXED-DURATION (FD) IBRUTINIB + VENETOCLAX FOR FIRST-LINE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)/SMALL LYMPHOCYTIC LYMPHOMA (SLL): 4-Y FOLLOW-UP FROM FD COHORT OF PH... by Paolo Ghia, John Allan, Tanya Siddiqi, William G. Wierda, Constantine Tam, Carol Moreno, Alessandra Tedeschi, Edith Szafer-Glusman, Cathy Zhou, Chris Abbazio, Jim Dean, Anita Szoke, Paul M. Barr

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A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. by Carmen D Schweighofer, Kevin R Coombes, Lynn L Barron, Lixia Diao, Rachel J Newman, Alessandra Ferrajoli, Susan O'Brien, William G Wierda, Rajyalakshmi Luthra, L Jeffrey Medeiros, Michael J Keating, Lynne V Abruzzo

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The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells. by Stefania Fiorcari, Wells S Brown, Bradley W McIntyre, Zeev Estrov, Rossana Maffei, Susan O'Brien, Mariela Sivina, Julia Hoellenriegel, William G Wierda, Michael J Keating, Wei Ding, Neil E Kay, Brian J Lannutti, Roberto Marasca, Jan A Burger

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Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations. by Drew C Deniger, Jianqiang Yu, M Helen Huls, Matthew J Figliola, Tiejuan Mi, Sourindra N Maiti, George F Widhopf, Lenka V Hurton, Radhika Thokala, Harjeet Singh, Simon Olivares, Richard E Champlin, William G Wierda, Thomas J Kipps, Laurence J N Cooper

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P377: A PHASE II TRIAL OF MINI-HYPER-CVD WITH VENETOCLAX FOR PATIENTS WITH RELAPSED/REFRACTORY (R/R) PHILADELPHIA CHROMOSOME (PH)-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) by Fadi Haddad, Elias Jabbour, Marianne Zoghbi, Nicholas Short, Jayastu Senapati, Walid Macaron, Cedric Nasnas, Lewis Nasr, Naveen Pemmaraju, Nitin Jain, William G. Wierda, Gautam Borthakur, Guillermo Montalban-Bravo, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Kelly Chien, Jennifer Thankachan, Rebecca Garris, Hagop Kantarjian

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S146: GENOMIC EVOLUTION AND RESISTANCE TO PIRTOBRUTINIB IN COVALENT BTK-INHIBITOR (CBTKI) PRE-TREATED CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PATIENTS: RESULTS FROM THE PHASE I/II BRUIN... by Jennifer R. Brown, Sai Prasad Desikan, Bastien Nguyen, Helen Won, Shady Tantawy, Samuel Clark Mcneely, Narasimha Marella, Kevin Ebata, Jennifer Woyach, Krish Patel, Constantine Tam, Toby Eyre, Chan Cheah, Nirav N Shah, Paolo Ghia, Wojciech Jurczak, Minna Balbas, Binoj Nair, Paolo Abada, Chunxiao Wang, Denise Wang, Anthony R. Mato, Varsha Gandhi, William G. Wierda

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Triplet therapy with venetoclax, FLT3 inhibitor and decitabine for FLT3-mutated acute myeloid leukemia by Abhishek Maiti, Courtney D. DiNardo, Naval G. Daver, Caitlin R. Rausch, Farhad Ravandi, Tapan M. Kadia, Naveen Pemmaraju, Gautam Borthakur, Prithviraj Bose, Ghayas C. Issa, Nicholas J. Short, Musa Yilmaz, Guillermo Montalban-Bravo, Alessandra Ferrajoli, Elias J. Jabbour, Nitin Jain, Maro Ohanian, Koichi Takahashi, Philip A. Thompson, Sanam Loghavi, Kathryn S. Montalbano, Sherry Pierce, William G. Wierda, Hagop M. Kantarjian, Marina Y. Konopleva

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Epstein–Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival by Alessandra Ferrajoli, Cristina Ivan, Maria Ciccone, Masayoshi Shimizu, Yoshiaki Kita, Masahisha Ohtsuka, Lucilla D'Abundo, Jun Qiang, Susan Lerner, Nazila Nouraee, Kari G. Rabe, Laura Z. Rassenti, Katrien Van Roosbroeck, John T. Manning, Yuan Yuan, Xinna Zhang, Tait D. Shanafelt, William G. Wierda, Silvia Sabbioni, Jeffrey J. Tarrand, Zeev Estrov, Milan Radovich, Han Liang, Massimo Negrini, Thomas J. Kipps, Neil E. Kay, Michael Keating, George A. Calin

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Impact of prior therapies and subsequent transplantation on outcomes in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia treated with brexucabtagene a... by Daniel J DeAngelo, Yi Lin, Roch Houot, Marion Subklewe, Petra C Schuberth, Michael R Bishop, Nicolas Boissel, Dimitrios Tzachanis, Jae H Park, Monique C Minnema, Thibaut Leguay, Mehrdad Abedi, Bijal D Shah, Ryan D Cassaday, Olalekan O Oluwole, Aaron C Logan, Max S Topp, Kristen M O'Dwyer, Martha L Arellano, Maria R Baer, Gary J Schiller, William G Wierda, Patrick J Stiff, Deepa Jeyakumar, Daqin Mao, Sabina Adhikary, Lang Zhou, Rita Damico Khalid, Armin Ghobadia

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Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external hist... by Bijal D. Shah, Armin Ghobadi, Olalekan O. Oluwole, Aaron C. Logan, Nicolas Boissel, Ryan D. Cassaday, Thibaut Leguay, Michael R. Bishop, Max S. Topp, Dimitrios Tzachanis, Kristen M. O’Dwyer, Martha L. Arellano, Yi Lin, Maria R. Baer, Gary J. Schiller, Jae H. Park, Marion Subklewe, Mehrdad Abedi, Monique C. Minnema, William G. Wierda, Daniel J. DeAngelo, Patrick Stiff, Deepa Jeyakumar, Jinghui Dong, Sabina Adhikary, Lang Zhou, Petra C. Schuberth, Imi Faghmous, Behzad Kharabi Masouleh, Roch Houot

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