1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer by Stefani Spranger, Rakesh K Jain, Kim Nguyen, Arjun Bhutkar, Ivy Chen, Dig Bijay Mahat, Heena Kumra, Emily Metcalf, Sarah Castro, William W Ho, Brandon Sullivan, Leon K Yim, Vikash Chauhan, Hernandez Moura Silva, Phillip A Sharp