Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug developme... by Imprachim, N, Yosaatmadja, Y, Newman, JA

The SNM1A DNA repair nuclease by Baddock, HT, Yosaatmadja, Y, Newman, JA, Schofield, CJ, Gileadi, O, McHugh, PJ

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family by Baddock, HT, Newman, JA, Yosaatmadja, Y, Bielinski, M, Schofield, CJ, Gileadi, O, McHugh, PJ

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition by Yosaatmadja, Y, Baddock, HT, Newman, JA, Bielinski, M, Gavard, AE, Mukhopadhyay, SMM, Dannerfjord, AA, Schofield, CJ, McHugh, PJ, Gileadi, O

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification by Baddock, H, Brolih, S, Yosaatmadja, Y, Ratnaweera, M, Bielinski, M, Swift, L, Cruz-Migoni, A, Morris, G, Schofield, C, Gileadi, O, McHugh, P

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase by Newman, JA, Douangamath, A, Yadzani, S, Yosaatmadja, Y, Aimon, A, Brandão-Neto, J, Dunnett, L, Gorrie-Stone, T, Skyner, R, Fearon, D, Schapira, M, von Delft, F, Gileadi, O

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification by Baddock, HT, Brolih, S, Yosaatmadja, Y, Ratnaweera, M, Bielinski, M, Swift, LP, Cruz-Migoni, A, Fan, H, Keown, JR, Walker, AP, Morris, GM, Grimes, JM, Fodor, E, Schofield, CJ, Gileadi, O, McHugh, PJ

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target by Bielinski, M, Henderson, LR, Yosaatmadja, Y, Swift, LP, Baddock, HT, Bowen, MJ, Brem, J, Jones, PS, McElroy, SP, Morrison, A, Speake, M, van Boeckel, S, van Doornmalen, E, van Groningen, J, van den Hurk, H, Gileadi, O, Newman, JA, McHugh, PJ, Schofield, CJ