Editorial: Development of in vitro toxicology methods using organoid systems and toxicogenomic approaches by Toshio Imai, Yoshitaka Hippo

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Current Status of Patient-Derived Ovarian Cancer Models by Yoshiaki Maru, Yoshitaka Hippo

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Recent Advances in Implantation-Based Genetic Modeling of Biliary Carcinogenesis in Mice by Masashi Izumiya, Shingo Kato, Yoshitaka Hippo

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Structural characterization of human de novo protein NCYM and its complex with a newly identified DNA aptamer using atomic force microscopy and small-angle X-ray scattering by Seigi Yamamoto, Fumiaki Kono, Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Miwako Hirose, Katsunori Horii, Yoshitaka Hippo, Yoshitaka Hippo, Yoshitaka Hippo, Taro Tamada, Taro Tamada, Yusuke Suenaga, Tatsuhito Matsuo

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Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance by Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Hiroyuki Kogashi, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yoshitaka Hippo, Yoshitaka Hippo, Yusuke Suenaga

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Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition by Yoshiaki Maru, Naotake Tanaka, Yasutoshi Tatsumi, Yuki Nakamura, Makiko Itami, Yoshitaka Hippo

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Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis by Chen-Ju Lin, Zeina Nasr, Prem K. Premsrirut, John A. Porco, Jr., Yoshitaka Hippo, Scott W. Lowe, Jerry Pelletier

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Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix by Yoshiaki Maru, Akira Kawata, Ayumi Taguchi, Yoshiyuki Ishii, Satoshi Baba, Mayuyo Mori, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Yutaka Osuga, Tomoyuki Fujii, Yoshitaka Hippo

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Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds by Shingo Kato, Kentaro Fushimi, Yuichiro Yabuki, Yoshiaki Maru, Sho Hasegawa, Tetsuya Matsuura, Daisuke Kurotaki, Akihiro Suzuki, Noritoshi Kobayashi, Masato Yoneda, Takuma Higurashi, Makiko Enaka, Tomohiko Tamura, Yoshitaka Hippo, Atsushi Nakajima

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Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells. by Yuko Atsumi, Hiroaki Fujimori, Hirokazu Fukuda, Aki Inase, Keitaro Shinohe, Yoshiko Yoshioka, Mima Shikanai, Yosuke Ichijima, Junya Unno, Shuki Mizutani, Naoto Tsuchiya, Yoshitaka Hippo, Hitoshi Nakagama, Mitsuko Masutani, Hirobumi Teraoka, Ken-ichi Yoshioka

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Application of organoid culture from HPV18‐positive small cell carcinoma of the uterine cervix for precision medicine by Misako Kusakabe, Ayumi Taguchi, Michihiro Tanikawa, Daisuke Hoshi, Saki Tsuchimochi, Xi Qian, Yusuke Toyohara, Akira Kawata, Ryota Wagatsuma, Kohei Yamaguchi, Yoko Yamamoto, Masako Ikemura, Kenbun Sone, Mayuyo Mori‐Uchino, Hiroko Matsunaga, Tetsushi Tsuruga, Takeshi Nagamatsu, Iwao Kukimoto, Osamu Wada‐Hiraike, Masahito Kawazu, Tetsuo Ushiku, Haruko Takeyama, Katsutoshi Oda, Kei Kawana, Yoshitaka Hippo, Yutaka Osuga

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