Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease by Phoebe Valdes, Andrew B. Caldwell, Qing Liu, Michael Q. Fitzgerald, Srinivasan Ramachandran, Celeste M. Karch, Dominantly Inherited Alzheimer Network (DIAN), Douglas R. Galasko, Shauna H. Yuan, Steven L. Wagner, Shankar Subramaniam

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Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure by Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, The Dominantly Inherited Alzheimer Network (DIAN), Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga, Oscar Harari

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Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort by Reddy Peera Kommaddi, Aditi Verma, Graciela Muniz-Terrera, Vivek Tiwari, Keerthana Chithanathan, Latha Diwakar, Ruturaj Gowaikar, Smitha Karunakaran, Palash Kumar Malo, Neill R. Graff-Radford, Gregory S. Day, Christoph Laske, Jonathan Vöglein, Georg Nübling, Takeshi Ikeuchi, Kensaku Kasuga, the Dominantly Inherited Alzheimer Network (DIAN), Vijayalakshmi Ravindranath

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Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study by Peter R Millar, Brian A Gordon, Patrick H Luckett, Tammie LS Benzinger, Carlos Cruchaga, Anne M Fagan, Jason J Hassenstab, Richard J Perrin, Suzanne E Schindler, Ricardo F Allegri, Gregory S Day, Martin R Farlow, Hiroshi Mori, Georg Nübling, The Dominantly Inherited Alzheimer Network, Randall J Bateman, John C Morris, Beau M Ances

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Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae by Christine Rother, Ruth E. Uhlmann, Stephan A. Müller, Juliane Schelle, Angelos Skodras, Ulrike Obermüller, Lisa M. Häsler, Marius Lambert, Frank Baumann, Ying Xu, Carina Bergmann, Giulia Salvadori, Maarten Loos, Irena Brzak, Derya Shimshek, Ulf Neumann, Dominantly Inherited Alzheimer Network, Lary C. Walker, Stephanie A. Schultz, Jasmeer P. Chhatwal, Stephan A. Kaeser, Stefan F. Lichtenthaler, Matthias Staufenbiel, Mathias Jucker

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Herpes simplex virus and rates of cognitive decline or whole brain atrophy in the Dominantly Inherited Alzheimer Network by Charlotte Warren‐Gash, Sharon L. Cadogan, Jennifer M. Nicholas, Judith M. Breuer, Divya Shah, Neil Pearce, Suhail Shiekh, Liam Smeeth, Martin R. Farlow, Hiroshi Mori, Brian A. Gordon, Georg Nuebling, Eric McDade, Randall J. Bateman, Peter R. Schofield, Jae‐Hong Lee, John C. Morris, David M. Cash, Nick C. Fox, Basil H. Ridha, Martin N. Rossor, for the Dominantly Inherited Alzheimer Network

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Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease by Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga

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Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers by Logan Brase, Shih-Feng You, Ricardo D’Oliveira Albanus, Jorge L. Del-Aguila, Yaoyi Dai, Brenna C. Novotny, Carolina Soriano-Tarraga, Taitea Dykstra, Maria Victoria Fernandez, John P. Budde, Kristy Bergmann, John C. Morris, Randall J. Bateman, Richard J. Perrin, Eric McDade, Chengjie Xiong, Alison M. Goate, Martin Farlow, Dominantly Inherited Alzheimer Network (DIAN), Greg T. Sutherland, Jonathan Kipnis, Celeste M. Karch, Bruno A. Benitez, Oscar Harari

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CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline by Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative

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Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. by Muhammad Ali, Yun Ju Sung, Fengxian Wang, Maria V Fernández, John C Morris, Anne M Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleó, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin R Farlow, Richard J Perrin, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN), Carlos Cruchaga

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Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America by Leonel Tadao Takada, Carmen Aláez-Verson, Bhagyashri D. Burgute, Ricardo Nitrini, Ana Luisa Sosa, Raphael Machado Castilhos, Marcia Fagundes Chaves, Erika-Mariana Longoria, Karol Carrillo-Sánchez, Sonia Maria Dozzi Brucki, Luis Leonardo Flores-Lagunes, Carolina Molina, Marcos Jimenez Olivares, Ellen Ziegemeier, Jennifer Petranek, Alison M. Goate, Carlos Cruchaga, Alan E. Renton, Maria Victoria Fernández, Gregory S. Day, Eric McDade, Randall J. Bateman, Celeste M. Karch, Jorge J. Llibre-Guerra, for the Dominantly Inherited Alzheimer Network

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Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease by Nelly Joseph‐Mathurin, Yi Su, Tyler M. Blazey, Mateusz Jasielec, Andrei Vlassenko, Karl Friedrichsen, Brian A. Gordon, Russ C. Hornbeck, Lisa Cash, Beau M. Ances, Thomas Veale, David M. Cash, Adam M. Brickman, Virginia Buckles, Nigel J. Cairns, Carlos Cruchaga, Alison Goate, Clifford R. Jack Jr., Celeste Karch, William Klunk, Robert A. Koeppe, Daniel S. Marcus, Richard Mayeux, Eric McDade, James M. Noble, John Ringman, Andrew J. Saykin, Paul M. Thompson, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger, Dominantly Inherited Alzheimer Network

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Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease by Anna Hofmann, Lisa M. Häsler, Marius Lambert, Stephan A. Kaeser, Susanne Gräber-Sultan, Ulrike Obermüller, Elke Kuder-Buletta, Christian la Fougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Nick C. Fox, Natalie S. Ryan, Henrik Zetterberg, Jorge J. Llibre-Guerra, Richard J. Perrin, Laura Ibanez, Peter R. Schofield, William S. Brooks, Gregory S. Day, Martin R. Farlow, Ricardo F. Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, Jae-Hong Lee, Jee Hoon Roh, Hiroshi Mori, Francisco Lopera, Randall J. Bateman, Eric McDade, Brian A. Gordon, Jasmeer P. Chhatwal, Mathias Jucker, Stephanie A. Schultz, Dominantly Inherited Alzheimer Network

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Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease by Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricardo F Allegri, Sarah B Berman, Jasmeer P Chhatwal, Patricio A Chrem Mendez, Gregory S Day, Anna Hofmann, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Yoshiki Niimi, Victor J Sánchez-González, Peter R Schofield, Ana Luisa Sosa-Ortiz, Jonathan Vöglein, for the Dominantly Inherited Alzheimer Network, Randall J Bateman, Beau M Ances, Eric M McDade

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Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease by Ophir Keret, Adam M. Staffaroni, John M. Ringman, Yann Cobigo, Sheng‐Yang M. Goh, Amy Wolf, Isabel Elaine Allen, Stephen Salloway, Jasmeer Chhatwal, Adam M. Brickman, Dolly Reyes‐Dumeyer, Randal J. Bateman, Tammie L.S. Benzinger, John C. Morris, Beau M. Ances, Nelly Joseph‐Mathurin, Richard J. Perrin, Brian A. Gordon, Johannes Levin, Jonathan Vöglein, Mathias Jucker, Christian laFougère, Ralph N. Martins, Hamid R. Sohrabi, Kevin Taddei, Victor L. Villemagne, Peter R. Schofield, William S. Brooks, Michael Fulham, Colin L. Masters, Bernardino Ghetti, Andrew J. Saykin, Clifford R. Jack, Neill R. Graff‐Radford, Michael Weiner, David M. Cash, Ricardo F. Allegri, Patricio Chrem, Su Yi, Bruce L. Miller, Gil D. Rabinovici, Howard J. Rosen, Dominantly Inherited Alzheimer Network

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Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease by Muhammad Ali, Derek B. Archer, Priyanka Gorijala, Daniel Western, Jigyasha Timsina, Maria V. Fernández, Ting-Chen Wang, Claudia L. Satizabal, Qiong Yang, Alexa S. Beiser, Ruiqi Wang, Gengsheng Chen, Brian Gordon, Tammie L. S. Benzinger, Chengjie Xiong, John C. Morris, Randall J. Bateman, Celeste M. Karch, Eric McDade, Alison Goate, Sudha Seshadri, Richard P. Mayeux, Reisa A. Sperling, Rachel F. Buckley, Keith A. Johnson, Hong-Hee Won, Sang-Hyuk Jung, Hang-Rai Kim, Sang Won Seo, Hee Jin Kim, Elizabeth Mormino, Simon M. Laws, Kang-Hsien Fan, M. Ilyas Kamboh, Prashanthi Vemuri, Vijay K. Ramanan, Hyun-Sik Yang, Allen Wenzel, Hema Sekhar Reddy Rajula, Aniket Mishra, Carole Dufouil, Stephanie Debette, Oscar L. Lopez, Steven T. DeKosky, Feifei Tao, Michael W. Nagle, Knight Alzheimer Disease Research Center (Knight ADRC), the Dominantly Inherited Alzheimer Network (DIAN), Alzheimer’s Disease Neuroimaging Initiative (ADNI), ADNI-DOD, A4 Study Team, the Australian Imaging Biomarkers, Lifestyle (AIBL) Study, Timothy J. Hohman, Yun Ju Sung, Logan Dumitrescu, Carlos Cruchaga

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