TOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS /
Toxicity has been estimated to be responsible for the erosion of ~ 1/3 of drug candidates and is a major contributor to the high cost of drug development, particularly when not recognized until late in the clinical trials or post-marketing. The causes of drug toxicity can be organized in several way...
| Principais autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | |
| Idioma: | eng |
| Publicado em: |
United Kingdom : Auris Reference Limited,
2020
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| Assuntos: |
| _version_ | 1826471636831830016 |
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| author | Mansour, Sameeh Abdel-Kadir, contributor 642707 Abbassy, Mostafa Abdel-Latif, contributor 642708 Shaldam, Hassan Aly, contributor 642709 Garvey, Mary, contributor 642710 Padmanabhan, Sibu C., contributor 642711 Pillai, Suresh C., contributor 642712 Cruz-Romero, Malco, contributor 642713 Kerry, Joseph P., contributor 642714 Morris, Michael A., contributor 642640 Guo-Ross, Shirley X., contributor 642715 Meek, Edward C., contributor 642716 Chambers, Janice E., contributor 385612 Carr, Rusell L., contributor 642717 Jayasekara, P. B., contributor 642718 Silvaneasharajah, L., contributor 642719 Perera, J., contributor 642720 Karunaratne, D. D., contributor 642721 Sandaruwan, K. D., contributor 642722 Rajapakse, R. N., contributor 642723 Banaszkiewiez, Laura, contributor 642724 Wiergowski, Marek, contributor 642725 Tomezak, Ewa, contributor 642726 Kata, Marzena, contributor 642727 Szpiech, Beata, contributor 642728 Namieśnik, Jacek, contributor 572175 Biziuk, Marek, contributor 642729 Fatima, Nudrat, contributor 642730 Nayeem, Naira, contributor 642731 Lyubenova, Mariyana, contributor 642732 Boteva, Silvena, contributor 642733 Wilkinson, Helen, contributor 642734 DClinPsy, contributor 642735 Whittington, Richard, 1958-, contributor 330157 Perry, Lorraine, contributor 642736 Eames, Catrin, contributor 642737 |
| author_facet | Mansour, Sameeh Abdel-Kadir, contributor 642707 Abbassy, Mostafa Abdel-Latif, contributor 642708 Shaldam, Hassan Aly, contributor 642709 Garvey, Mary, contributor 642710 Padmanabhan, Sibu C., contributor 642711 Pillai, Suresh C., contributor 642712 Cruz-Romero, Malco, contributor 642713 Kerry, Joseph P., contributor 642714 Morris, Michael A., contributor 642640 Guo-Ross, Shirley X., contributor 642715 Meek, Edward C., contributor 642716 Chambers, Janice E., contributor 385612 Carr, Rusell L., contributor 642717 Jayasekara, P. B., contributor 642718 Silvaneasharajah, L., contributor 642719 Perera, J., contributor 642720 Karunaratne, D. D., contributor 642721 Sandaruwan, K. D., contributor 642722 Rajapakse, R. N., contributor 642723 Banaszkiewiez, Laura, contributor 642724 Wiergowski, Marek, contributor 642725 Tomezak, Ewa, contributor 642726 Kata, Marzena, contributor 642727 Szpiech, Beata, contributor 642728 Namieśnik, Jacek, contributor 572175 Biziuk, Marek, contributor 642729 Fatima, Nudrat, contributor 642730 Nayeem, Naira, contributor 642731 Lyubenova, Mariyana, contributor 642732 Boteva, Silvena, contributor 642733 Wilkinson, Helen, contributor 642734 DClinPsy, contributor 642735 Whittington, Richard, 1958-, contributor 330157 Perry, Lorraine, contributor 642736 Eames, Catrin, contributor 642737 |
| author_sort | Mansour, Sameeh Abdel-Kadir, contributor 642707 |
| collection | OCEAN |
| description | Toxicity has been estimated to be responsible for the erosion of ~ 1/3 of drug candidates and is a major contributor to the high cost of drug development, particularly when not recognized until late in the clinical trials or post-marketing. The causes of drug toxicity can be organized in several ways and include mechanismbased (on-target) toxicity, immune hypersensitivity, off-target toxicity, and bioactivation/covalent modification. In addition, idiosyncratic responses are rare but one of the most problematic issues; several hypotheses for these have been advanced. An understanding of the mechanisms of toxicity provides a rational basis for interpreting descriptive toxicity data. The cellular mechanisms that contribute to the manifestation of toxicities are overviewed by relating a series of events that begins with exposure, involves a multitude of interactions between the invading toxicant and the organism, and culminates in a toxic effect. |
| first_indexed | 2024-03-05T17:06:21Z |
| format | |
| id | KOHA-OAI-TEST:600497 |
| institution | Universiti Teknologi Malaysia - OCEAN |
| language | eng |
| last_indexed | 2024-03-05T17:06:21Z |
| publishDate | 2020 |
| publisher | United Kingdom : Auris Reference Limited, |
| record_format | dspace |
| spelling | KOHA-OAI-TEST:6004972022-08-17T02:06:21ZTOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS / Mansour, Sameeh Abdel-Kadir, contributor 642707 Abbassy, Mostafa Abdel-Latif, contributor 642708 Shaldam, Hassan Aly, contributor 642709 Garvey, Mary, contributor 642710 Padmanabhan, Sibu C., contributor 642711 Pillai, Suresh C., contributor 642712 Cruz-Romero, Malco, contributor 642713 Kerry, Joseph P., contributor 642714 Morris, Michael A., contributor 642640 Guo-Ross, Shirley X., contributor 642715 Meek, Edward C., contributor 642716 Chambers, Janice E., contributor 385612 Carr, Rusell L., contributor 642717 Jayasekara, P. B., contributor 642718 Silvaneasharajah, L., contributor 642719 Perera, J., contributor 642720 Karunaratne, D. D., contributor 642721 Sandaruwan, K. D., contributor 642722 Rajapakse, R. N., contributor 642723 Banaszkiewiez, Laura, contributor 642724 Wiergowski, Marek, contributor 642725 Tomezak, Ewa, contributor 642726 Kata, Marzena, contributor 642727 Szpiech, Beata, contributor 642728 Namieśnik, Jacek, contributor 572175 Biziuk, Marek, contributor 642729 Fatima, Nudrat, contributor 642730 Nayeem, Naira, contributor 642731 Lyubenova, Mariyana, contributor 642732 Boteva, Silvena, contributor 642733 Wilkinson, Helen, contributor 642734 DClinPsy, contributor 642735 Whittington, Richard, 1958-, contributor 330157 Perry, Lorraine, contributor 642736 Eames, Catrin, contributor 642737 United Kingdom : Auris Reference Limited,2020©2020engToxicity has been estimated to be responsible for the erosion of ~ 1/3 of drug candidates and is a major contributor to the high cost of drug development, particularly when not recognized until late in the clinical trials or post-marketing. The causes of drug toxicity can be organized in several ways and include mechanismbased (on-target) toxicity, immune hypersensitivity, off-target toxicity, and bioactivation/covalent modification. In addition, idiosyncratic responses are rare but one of the most problematic issues; several hypotheses for these have been advanced. An understanding of the mechanisms of toxicity provides a rational basis for interpreting descriptive toxicity data. The cellular mechanisms that contribute to the manifestation of toxicities are overviewed by relating a series of events that begins with exposure, involves a multitude of interactions between the invading toxicant and the organism, and culminates in a toxic effect.Includes references and index.Toxicity has been estimated to be responsible for the erosion of ~ 1/3 of drug candidates and is a major contributor to the high cost of drug development, particularly when not recognized until late in the clinical trials or post-marketing. The causes of drug toxicity can be organized in several ways and include mechanismbased (on-target) toxicity, immune hypersensitivity, off-target toxicity, and bioactivation/covalent modification. In addition, idiosyncratic responses are rare but one of the most problematic issues; several hypotheses for these have been advanced. An understanding of the mechanisms of toxicity provides a rational basis for interpreting descriptive toxicity data. The cellular mechanisms that contribute to the manifestation of toxicities are overviewed by relating a series of events that begins with exposure, involves a multitude of interactions between the invading toxicant and the organism, and culminates in a toxic effect.PSZJBLClinical toxicologyURN:ISBN:9781788027328 |
| spellingShingle | Clinical toxicology Mansour, Sameeh Abdel-Kadir, contributor 642707 Abbassy, Mostafa Abdel-Latif, contributor 642708 Shaldam, Hassan Aly, contributor 642709 Garvey, Mary, contributor 642710 Padmanabhan, Sibu C., contributor 642711 Pillai, Suresh C., contributor 642712 Cruz-Romero, Malco, contributor 642713 Kerry, Joseph P., contributor 642714 Morris, Michael A., contributor 642640 Guo-Ross, Shirley X., contributor 642715 Meek, Edward C., contributor 642716 Chambers, Janice E., contributor 385612 Carr, Rusell L., contributor 642717 Jayasekara, P. B., contributor 642718 Silvaneasharajah, L., contributor 642719 Perera, J., contributor 642720 Karunaratne, D. D., contributor 642721 Sandaruwan, K. D., contributor 642722 Rajapakse, R. N., contributor 642723 Banaszkiewiez, Laura, contributor 642724 Wiergowski, Marek, contributor 642725 Tomezak, Ewa, contributor 642726 Kata, Marzena, contributor 642727 Szpiech, Beata, contributor 642728 Namieśnik, Jacek, contributor 572175 Biziuk, Marek, contributor 642729 Fatima, Nudrat, contributor 642730 Nayeem, Naira, contributor 642731 Lyubenova, Mariyana, contributor 642732 Boteva, Silvena, contributor 642733 Wilkinson, Helen, contributor 642734 DClinPsy, contributor 642735 Whittington, Richard, 1958-, contributor 330157 Perry, Lorraine, contributor 642736 Eames, Catrin, contributor 642737 TOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS / |
| title | TOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS / |
| title_full | TOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS / |
| title_fullStr | TOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS / |
| title_full_unstemmed | TOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS / |
| title_short | TOXICOLOGY : MECHANISMS AND ANALYTICAL METHODS / |
| title_sort | toxicology mechanisms and analytical methods |
| topic | Clinical toxicology |
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