Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines
A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) an...
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2017
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| Online Access: | http://umpir.ump.edu.my/id/eprint/16454/1/fist-2017-nadeem-Synthesis%20and%20cytotoxic1.pdf |
| _version_ | 1825823517951655936 |
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| author | Akhtar, Muhammad Nadeem Ali Salim, Landa Zeenelabdin Swee, Keong Yeap Nadiah, Abu Seema, Zareen Kong, Mun Lo Addila, Abu Bakar Noorjahan Banu, Alitheen |
| author_facet | Akhtar, Muhammad Nadeem Ali Salim, Landa Zeenelabdin Swee, Keong Yeap Nadiah, Abu Seema, Zareen Kong, Mun Lo Addila, Abu Bakar Noorjahan Banu, Alitheen |
| author_sort | Akhtar, Muhammad Nadeem |
| collection | UMP |
| description | A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) and normal breast cell (MCF-10A). The structure of DMMF was determined by EI-MS, 1H NMR and single X-ray crystallographic techniques. The DMMF possessed the highest cytotoxic effect against MCF-7 breast cancer cell (2.01 ± 1.53 μg/mL) and lowest against normal hepatic WRL-68 and breast cell lines after 24 h of treatment. Induction of apoptosis and regulation of cell cycle progression results indicates the significant increase in early apoptosis and G2/M arrest after 48 h of treatment in MCF-7 cells. Meanwhile, in MDA-MB231 cells, there was an increase in Sub G0/G1 cells population and early/late apoptotic cells upon treatment with DMMF. Additionally, DMMF effectively induced G2/M cell cycle arrest in MCF-7 cells and apoptosis in both MCF-7 and MDA-MB231 cells. |
| first_indexed | 2024-03-06T12:12:25Z |
| format | Article |
| id | UMPir16454 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:12:25Z |
| publishDate | 2017 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | UMPir164542019-10-30T04:14:10Z http://umpir.ump.edu.my/id/eprint/16454/ Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines Akhtar, Muhammad Nadeem Ali Salim, Landa Zeenelabdin Swee, Keong Yeap Nadiah, Abu Seema, Zareen Kong, Mun Lo Addila, Abu Bakar Noorjahan Banu, Alitheen Q Science (General) A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) and normal breast cell (MCF-10A). The structure of DMMF was determined by EI-MS, 1H NMR and single X-ray crystallographic techniques. The DMMF possessed the highest cytotoxic effect against MCF-7 breast cancer cell (2.01 ± 1.53 μg/mL) and lowest against normal hepatic WRL-68 and breast cell lines after 24 h of treatment. Induction of apoptosis and regulation of cell cycle progression results indicates the significant increase in early apoptosis and G2/M arrest after 48 h of treatment in MCF-7 cells. Meanwhile, in MDA-MB231 cells, there was an increase in Sub G0/G1 cells population and early/late apoptotic cells upon treatment with DMMF. Additionally, DMMF effectively induced G2/M cell cycle arrest in MCF-7 cells and apoptosis in both MCF-7 and MDA-MB231 cells. Elsevier Ltd 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16454/1/fist-2017-nadeem-Synthesis%20and%20cytotoxic1.pdf Akhtar, Muhammad Nadeem and Ali Salim, Landa Zeenelabdin and Swee, Keong Yeap and Nadiah, Abu and Seema, Zareen and Kong, Mun Lo and Addila, Abu Bakar and Noorjahan Banu, Alitheen (2017) Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines. Phytochemistry Letters, 19. pp. 145-150. ISSN 1874-3900. (Published) https://doi.org/10.1016/j.phytol.2016.12.022 DOI: 10.1016/j.phytol.2016.12.022 |
| spellingShingle | Q Science (General) Akhtar, Muhammad Nadeem Ali Salim, Landa Zeenelabdin Swee, Keong Yeap Nadiah, Abu Seema, Zareen Kong, Mun Lo Addila, Abu Bakar Noorjahan Banu, Alitheen Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines |
| title | Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines |
| title_full | Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines |
| title_fullStr | Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines |
| title_full_unstemmed | Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines |
| title_short | Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines |
| title_sort | synthesis and cytotoxic effects of e 3 2 3 dimethoxyphenyl 1 5 methylfuran 2 yl prop 2 en 1 one in mda mb231 and mcf 7 breast cancer cell lines |
| topic | Q Science (General) |
| url | http://umpir.ump.edu.my/id/eprint/16454/1/fist-2017-nadeem-Synthesis%20and%20cytotoxic1.pdf |
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