Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
Background The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd.
2016
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| Online Access: | http://umpir.ump.edu.my/id/eprint/16809/1/fist-2016-nadeem-Flavokawain%20B%20induced1.pdf |
| _version_ | 1825823578198638592 |
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| author | Nadiah, Abu Akhtar, Muhammad Nadeem Swee, K. Yeap Kian, Lam Lim Wan, Yong Ho Mohd Puad, Abdullah Chai, Ling Ho Abdul Rahman, Omar Jamil, Ismail Noorjahan Banu, Alitheen |
| author_facet | Nadiah, Abu Akhtar, Muhammad Nadeem Swee, K. Yeap Kian, Lam Lim Wan, Yong Ho Mohd Puad, Abdullah Chai, Ling Ho Abdul Rahman, Omar Jamil, Ismail Noorjahan Banu, Alitheen |
| author_sort | Nadiah, Abu |
| collection | UMP |
| description | Background
The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated. |
| first_indexed | 2024-03-06T12:13:17Z |
| format | Article |
| id | UMPir16809 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:13:17Z |
| publishDate | 2016 |
| publisher | BioMed Central Ltd. |
| record_format | dspace |
| spelling | UMPir168092017-11-17T06:46:29Z http://umpir.ump.edu.my/id/eprint/16809/ Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro Nadiah, Abu Akhtar, Muhammad Nadeem Swee, K. Yeap Kian, Lam Lim Wan, Yong Ho Mohd Puad, Abdullah Chai, Ling Ho Abdul Rahman, Omar Jamil, Ismail Noorjahan Banu, Alitheen QR Microbiology Background The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated. BioMed Central Ltd. 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16809/1/fist-2016-nadeem-Flavokawain%20B%20induced1.pdf Nadiah, Abu and Akhtar, Muhammad Nadeem and Swee, K. Yeap and Kian, Lam Lim and Wan, Yong Ho and Mohd Puad, Abdullah and Chai, Ling Ho and Abdul Rahman, Omar and Jamil, Ismail and Noorjahan Banu, Alitheen (2016) Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro. BMC Complementary and Alternative Medicine, 16 (86). pp. 1-14. ISSN 1472-6882. (Published) http://doi.org/10.1186/s12906-016-1046-8 doi: 10.1186/s12906-016-1046-8 |
| spellingShingle | QR Microbiology Nadiah, Abu Akhtar, Muhammad Nadeem Swee, K. Yeap Kian, Lam Lim Wan, Yong Ho Mohd Puad, Abdullah Chai, Ling Ho Abdul Rahman, Omar Jamil, Ismail Noorjahan Banu, Alitheen Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro |
| title | Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro |
| title_full | Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro |
| title_fullStr | Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro |
| title_full_unstemmed | Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro |
| title_short | Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro |
| title_sort | flavokawain b induced cytotoxicity in two breast cancer cell lines mcf 7 and mda mb231 and inhibited the metastatic potential of mda mb231 via the regulation of several tyrosine kinases in vitro |
| topic | QR Microbiology |
| url | http://umpir.ump.edu.my/id/eprint/16809/1/fist-2016-nadeem-Flavokawain%20B%20induced1.pdf |
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