Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods...
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| Format: | Article |
| Language: | English |
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Informatics Publishing Limited
2017
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/17467/1/fkksa-2017-syarifah-Preliminary%20Study%20on%20Operating%20Parameters.pdf |
| _version_ | 1825823696885907456 |
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| author | Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar |
| author_facet | Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar |
| author_sort | Engku Nadia, Engku Mat Nasir |
| collection | UMP |
| description | Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs. |
| first_indexed | 2024-03-06T12:15:00Z |
| format | Article |
| id | UMPir17467 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:15:00Z |
| publishDate | 2017 |
| publisher | Informatics Publishing Limited |
| record_format | dspace |
| spelling | UMPir174672019-10-30T07:38:24Z http://umpir.ump.edu.my/id/eprint/17467/ Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar TP Chemical technology Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs. Informatics Publishing Limited 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/17467/1/fkksa-2017-syarifah-Preliminary%20Study%20on%20Operating%20Parameters.pdf Engku Nadia, Engku Mat Nasir and Fatinah, Ab Rahman and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2017) Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal. Indian Journal of Science and Technology, 10 (7). pp. 1-5. ISSN 0974-6846 (Print); 0974-5645 (Online). (Published) http://www.indjst.org/index.php/indjst/article/view/111216 DOI: 10.17485/ijst/2017/v10i7/111216 |
| spellingShingle | TP Chemical technology Engku Nadia, Engku Mat Nasir Fatinah, Ab Rahman Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal |
| title | Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal |
| title_full | Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal |
| title_fullStr | Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal |
| title_full_unstemmed | Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal |
| title_short | Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal |
| title_sort | preliminary study on operating parameters toward the metastable zone width of carbamazepine co crystal |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/17467/1/fkksa-2017-syarifah-Preliminary%20Study%20on%20Operating%20Parameters.pdf |
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