The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory
Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The c...
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| Format: | Article |
| Language: | English |
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Wiley
2017
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| Online Access: | http://umpir.ump.edu.my/id/eprint/17822/1/fkm-2017-Mokhtarudin-The%20study%20of%20the%20function%20of%20AQP41.pdf |
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| author | Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J. |
| author_facet | Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J. |
| author_sort | Mohd Jamil Mohamed, Mokhtarudin |
| collection | UMP |
| description | Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The cerebral space is assumed to be made of four fluid compartments: astrocyte, neuron, ECS and blood microvessels, and a solid matrix for the tissue, and this is modelled using multiple-network poroelastic theory. AQP4 allows the movement of water between astrocyte and the ECS and the microvessels. It is found that the presence of AQP4 may help in reducing vasogenic oedema shown by a decrease in brain tissue extracellular pressure. However, the astrocyte pressure will increase to compensate for this decrease, which may lead to cytotoxic oedema. In addition, the swelling will also depend on the ionic concentrations in the astrocyte and extracellular space, which may change after ischaemic stroke. Understanding the role of AQP4 in oedema may thus help the development of a treatment plan in reducing brain swelling after ischaemia-reperfusion. |
| first_indexed | 2024-03-06T12:15:56Z |
| format | Article |
| id | UMPir17822 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:15:56Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | UMPir178222018-08-29T03:15:11Z http://umpir.ump.edu.my/id/eprint/17822/ The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J. TJ Mechanical engineering and machinery Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The cerebral space is assumed to be made of four fluid compartments: astrocyte, neuron, ECS and blood microvessels, and a solid matrix for the tissue, and this is modelled using multiple-network poroelastic theory. AQP4 allows the movement of water between astrocyte and the ECS and the microvessels. It is found that the presence of AQP4 may help in reducing vasogenic oedema shown by a decrease in brain tissue extracellular pressure. However, the astrocyte pressure will increase to compensate for this decrease, which may lead to cytotoxic oedema. In addition, the swelling will also depend on the ionic concentrations in the astrocyte and extracellular space, which may change after ischaemic stroke. Understanding the role of AQP4 in oedema may thus help the development of a treatment plan in reducing brain swelling after ischaemia-reperfusion. Wiley 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/17822/1/fkm-2017-Mokhtarudin-The%20study%20of%20the%20function%20of%20AQP41.pdf Mohd Jamil Mohamed, Mokhtarudin and Payne, Stephen J. (2017) The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory. International Journal for Numerical Methods In Biomedical Engineering, 33 (1). pp. 1-14. ISSN 2040-7939 (print); 2040-7947 (online). (Published) https://doi.org/10.1002/cnm.2784 DOI: 10.1002/cnm.2784 |
| spellingShingle | TJ Mechanical engineering and machinery Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J. The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory |
| title | The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory |
| title_full | The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory |
| title_fullStr | The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory |
| title_full_unstemmed | The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory |
| title_short | The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory |
| title_sort | study of the function of aqp4 in cerebral ischaemia reperfusion injury using poroelastic theory |
| topic | TJ Mechanical engineering and machinery |
| url | http://umpir.ump.edu.my/id/eprint/17822/1/fkm-2017-Mokhtarudin-The%20study%20of%20the%20function%20of%20AQP41.pdf |
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