Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology
Phaleria macrocarpa locally known as Mahkota Dewa is one of the important medicinal plants that originates from Papua Island, Indonesia and grows in tropical areas. Mangiferin is one of the major bioactive compounds of Phaleria macrocarpa. The effect of extraction time (4–6 h) and extraction tempera...
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| Format: | Article |
| Language: | English English |
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Elsevier GmbH
2017
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| Online Access: | http://umpir.ump.edu.my/id/eprint/18207/1/Optimization%20of%20mangiferin%20extrated%20from%20Phaleria%20macrocarpa%20fruits%20using%20response%20surface%20methodology.pdf http://umpir.ump.edu.my/id/eprint/18207/7/Optimization%20of%20mangiferin%20extrated%20from%20Phaleria%20macrocarpa%20fruits%20using%20response%20surface%20methodology%201.pdf |
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| author | Alara, Oluwaseun Ruth Siti Kholijah, Abdul Mudalip Olalere, Olusegun Abayomi |
| author_facet | Alara, Oluwaseun Ruth Siti Kholijah, Abdul Mudalip Olalere, Olusegun Abayomi |
| author_sort | Alara, Oluwaseun Ruth |
| collection | UMP |
| description | Phaleria macrocarpa locally known as Mahkota Dewa is one of the important medicinal plants that originates from Papua Island, Indonesia and grows in tropical areas. Mangiferin is one of the major bioactive compounds of Phaleria macrocarpa. The effect of extraction time (4–6 h) and extraction temperature (90–110 °C) on the mangiferin yield were investigated using Face Centered Central Composite Design (FCCCD) with five centre points under Response Surface Methodology (RSM). The presence of mangiferin in the extract was confirmed using HPLC-DAD and the functional groups were identified through FTIR analyses. A second order polynomial model was employed in predicting the response. The regression analysis showed that more than 98% of the variation was explained by the models with the optimum of 38.7 mg/g mangiferin yield at 105 °C and 6 h extraction time. The experimental values show good accuracy with those predicted (1.1% deviation), thus indicating the suitability of the model employed and the success of FCCCD in optimizing the extraction conditions. |
| first_indexed | 2024-03-06T12:16:59Z |
| format | Article |
| id | UMPir18207 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T12:16:59Z |
| publishDate | 2017 |
| publisher | Elsevier GmbH |
| record_format | dspace |
| spelling | UMPir182072019-09-10T04:46:38Z http://umpir.ump.edu.my/id/eprint/18207/ Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology Alara, Oluwaseun Ruth Siti Kholijah, Abdul Mudalip Olalere, Olusegun Abayomi TP Chemical technology Phaleria macrocarpa locally known as Mahkota Dewa is one of the important medicinal plants that originates from Papua Island, Indonesia and grows in tropical areas. Mangiferin is one of the major bioactive compounds of Phaleria macrocarpa. The effect of extraction time (4–6 h) and extraction temperature (90–110 °C) on the mangiferin yield were investigated using Face Centered Central Composite Design (FCCCD) with five centre points under Response Surface Methodology (RSM). The presence of mangiferin in the extract was confirmed using HPLC-DAD and the functional groups were identified through FTIR analyses. A second order polynomial model was employed in predicting the response. The regression analysis showed that more than 98% of the variation was explained by the models with the optimum of 38.7 mg/g mangiferin yield at 105 °C and 6 h extraction time. The experimental values show good accuracy with those predicted (1.1% deviation), thus indicating the suitability of the model employed and the success of FCCCD in optimizing the extraction conditions. Elsevier GmbH 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/18207/1/Optimization%20of%20mangiferin%20extrated%20from%20Phaleria%20macrocarpa%20fruits%20using%20response%20surface%20methodology.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/18207/7/Optimization%20of%20mangiferin%20extrated%20from%20Phaleria%20macrocarpa%20fruits%20using%20response%20surface%20methodology%201.pdf Alara, Oluwaseun Ruth and Siti Kholijah, Abdul Mudalip and Olalere, Olusegun Abayomi (2017) Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology. Journal of Applied Research on Medicinal and Aromatic Plants, 5. pp. 82-87. ISSN 2214-7861. (Published) http://www.sciencedirect.com/science/journal/22147861?sdc=1 DOI: 10.1016/j.jarmap.2017.02.002 |
| spellingShingle | TP Chemical technology Alara, Oluwaseun Ruth Siti Kholijah, Abdul Mudalip Olalere, Olusegun Abayomi Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology |
| title | Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology |
| title_full | Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology |
| title_fullStr | Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology |
| title_full_unstemmed | Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology |
| title_short | Optimization of Mangiferin Extrated from Phaleria Macrocarpa Fruits Using Response Surface Methodology |
| title_sort | optimization of mangiferin extrated from phaleria macrocarpa fruits using response surface methodology |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/18207/1/Optimization%20of%20mangiferin%20extrated%20from%20Phaleria%20macrocarpa%20fruits%20using%20response%20surface%20methodology.pdf http://umpir.ump.edu.my/id/eprint/18207/7/Optimization%20of%20mangiferin%20extrated%20from%20Phaleria%20macrocarpa%20fruits%20using%20response%20surface%20methodology%201.pdf |
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