Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity
6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 ± 0.20 μM) an...
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| Format: | Article |
| Language: | English |
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Elsevier
2017
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| Online Access: | http://umpir.ump.edu.my/id/eprint/19769/1/fist-2017-nadeem-Synthesis%20of%20a%20series%20of%20new%206-nitrobenzofuran-2-carbohydrazide1.pdf |
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| author | Taha, Muhammad Sultan, Sadia Mohamad, Azlan Syed Adnan, Ali Shah Jamil, Waqas Swee, KeongYeap Syahrul, Imran Akhtar, Muhammad Nadeem Seema, Zareen Nor Hadiani, Ismail Ali, Muhammad |
| author_facet | Taha, Muhammad Sultan, Sadia Mohamad, Azlan Syed Adnan, Ali Shah Jamil, Waqas Swee, KeongYeap Syahrul, Imran Akhtar, Muhammad Nadeem Seema, Zareen Nor Hadiani, Ismail Ali, Muhammad |
| author_sort | Taha, Muhammad |
| collection | UMP |
| description | 6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 ± 0.20 μM) and n-propyl gallate (IC50 = 30.30 ± 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 ± 0.90 μM), 2 (IC50 = 2.70 ± 0.25 μM), 3 (IC50 = 2.70 ± 0.25 μM), 10 (IC50 = 2.70 ± 1.10 μM), 11 (IC50 = 1.00 ± 1.20 μM), and 17 (IC50 = 3.75 ± 0.90 μM) showed excellent while 21 (IC50 = 7.50 ± 0.60 μM) and 28 (IC50 = 7.50 ± 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 ± 0.85 μM), 11 (IC50 = 24.20 ± 0.55 μM), 12 (IC50 = 21.10 ± 1.58 μM), 13 (IC50 = 14.60 ± 0.32 μM), 14 (IC50 = 29.20 ± 0.75 μM) and 15 (IC50 = 9.26 ± 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential. |
| first_indexed | 2024-03-06T12:20:28Z |
| format | Article |
| id | UMPir19769 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:20:28Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | UMPir197692018-04-05T06:16:02Z http://umpir.ump.edu.my/id/eprint/19769/ Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity Taha, Muhammad Sultan, Sadia Mohamad, Azlan Syed Adnan, Ali Shah Jamil, Waqas Swee, KeongYeap Syahrul, Imran Akhtar, Muhammad Nadeem Seema, Zareen Nor Hadiani, Ismail Ali, Muhammad Q Science (General) 6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 ± 0.20 μM) and n-propyl gallate (IC50 = 30.30 ± 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 ± 0.90 μM), 2 (IC50 = 2.70 ± 0.25 μM), 3 (IC50 = 2.70 ± 0.25 μM), 10 (IC50 = 2.70 ± 1.10 μM), 11 (IC50 = 1.00 ± 1.20 μM), and 17 (IC50 = 3.75 ± 0.90 μM) showed excellent while 21 (IC50 = 7.50 ± 0.60 μM) and 28 (IC50 = 7.50 ± 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 ± 0.85 μM), 11 (IC50 = 24.20 ± 0.55 μM), 12 (IC50 = 21.10 ± 1.58 μM), 13 (IC50 = 14.60 ± 0.32 μM), 14 (IC50 = 29.20 ± 0.75 μM) and 15 (IC50 = 9.26 ± 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential. Elsevier 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19769/1/fist-2017-nadeem-Synthesis%20of%20a%20series%20of%20new%206-nitrobenzofuran-2-carbohydrazide1.pdf Taha, Muhammad and Sultan, Sadia and Mohamad, Azlan and Syed Adnan, Ali Shah and Jamil, Waqas and Swee, KeongYeap and Syahrul, Imran and Akhtar, Muhammad Nadeem and Seema, Zareen and Nor Hadiani, Ismail and Ali, Muhammad (2017) Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity. New Horizons in Translational Medicine, 4 (1-4). pp. 23-30. ISSN 2307-5023. (Published) https://doi.org/10.1016/j.nhtm.2017.08.002 doi: 10.1016/j.nhtm.2017.08.002 |
| spellingShingle | Q Science (General) Taha, Muhammad Sultan, Sadia Mohamad, Azlan Syed Adnan, Ali Shah Jamil, Waqas Swee, KeongYeap Syahrul, Imran Akhtar, Muhammad Nadeem Seema, Zareen Nor Hadiani, Ismail Ali, Muhammad Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity |
| title | Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity |
| title_full | Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity |
| title_fullStr | Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity |
| title_full_unstemmed | Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity |
| title_short | Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity |
| title_sort | synthesis of a series of new 6 nitrobenzofuran 2 carbohydrazide derivatives with cytotoxic and antioxidant activity |
| topic | Q Science (General) |
| url | http://umpir.ump.edu.my/id/eprint/19769/1/fist-2017-nadeem-Synthesis%20of%20a%20series%20of%20new%206-nitrobenzofuran-2-carbohydrazide1.pdf |
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