Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution
The aim of study was to assess solubility and thermodynamic function of CBZ-SAC co-crystal in varying SAC concentrations in ethanolic solution at temperatures (25-50 oC). Experimental solubilities of CBZ-SAC co-crystal were determined by gravimetric and high performance liquid chromatography (HPLC)...
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| Format: | Conference or Workshop Item |
| Language: | English English |
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2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/22192/1/43.%20Solubility%20and%20thermodynamic%20function%20of%20carbamazepine-saccharin.pdf http://umpir.ump.edu.my/id/eprint/22192/2/43.1%20Solubility%20and%20thermodynamic%20function%20of%20carbamazepine-saccharin.pdf |
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| author | Fatinah, Ab Rahman Engku Nadia, Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar |
| author_facet | Fatinah, Ab Rahman Engku Nadia, Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar |
| author_sort | Fatinah, Ab Rahman |
| collection | UMP |
| description | The aim of study was to assess solubility and thermodynamic function of CBZ-SAC co-crystal in varying SAC concentrations in ethanolic solution at temperatures (25-50 oC). Experimental solubilities of CBZ-SAC co-crystal were determined by gravimetric and high performance liquid chromatography (HPLC) methods. Experimental solubilities of co-crystal in mole fraction from HPLC method were correlated well with Van’t Hoff model. The solubilities of co-crystal were obtained highest in CBZ : SAC with ratio of 1.00 : 1.00 and the co-crystal solubility is higher than the pure form of CBZ (Fig.1) [1]. Based on the apparent thermodynamic analysis parameter, it was indicated an “endothermic and entropy-driven dissolution” of CBZ-SAC co-crystal [2,3,4]. From these results, CBZ-SAC co-crystal has been considered freely soluble in ethanol solution with non-SAC excess. |
| first_indexed | 2024-03-06T12:26:24Z |
| format | Conference or Workshop Item |
| id | UMPir22192 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T12:26:24Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | UMPir221922019-10-30T07:39:03Z http://umpir.ump.edu.my/id/eprint/22192/ Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution Fatinah, Ab Rahman Engku Nadia, Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar TP Chemical technology The aim of study was to assess solubility and thermodynamic function of CBZ-SAC co-crystal in varying SAC concentrations in ethanolic solution at temperatures (25-50 oC). Experimental solubilities of CBZ-SAC co-crystal were determined by gravimetric and high performance liquid chromatography (HPLC) methods. Experimental solubilities of co-crystal in mole fraction from HPLC method were correlated well with Van’t Hoff model. The solubilities of co-crystal were obtained highest in CBZ : SAC with ratio of 1.00 : 1.00 and the co-crystal solubility is higher than the pure form of CBZ (Fig.1) [1]. Based on the apparent thermodynamic analysis parameter, it was indicated an “endothermic and entropy-driven dissolution” of CBZ-SAC co-crystal [2,3,4]. From these results, CBZ-SAC co-crystal has been considered freely soluble in ethanol solution with non-SAC excess. 2018-05 Conference or Workshop Item NonPeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/22192/1/43.%20Solubility%20and%20thermodynamic%20function%20of%20carbamazepine-saccharin.pdf pdf en http://umpir.ump.edu.my/id/eprint/22192/2/43.1%20Solubility%20and%20thermodynamic%20function%20of%20carbamazepine-saccharin.pdf Fatinah, Ab Rahman and Engku Nadia, Engku Mat Nasir and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2018) Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution. In: 13th International Workshop of The Crystal Growth of Organic Material , 27 - 30 Ogos 2018 , Korea University, Seoul, Korea. pp. 1-11.. (Unpublished) |
| spellingShingle | TP Chemical technology Fatinah, Ab Rahman Engku Nadia, Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution |
| title | Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution |
| title_full | Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution |
| title_fullStr | Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution |
| title_full_unstemmed | Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution |
| title_short | Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution |
| title_sort | solubility and thermodynamic function of carbamazepine saccharin cbz sac co crystal in ethanolic solution |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/22192/1/43.%20Solubility%20and%20thermodynamic%20function%20of%20carbamazepine-saccharin.pdf http://umpir.ump.edu.my/id/eprint/22192/2/43.1%20Solubility%20and%20thermodynamic%20function%20of%20carbamazepine-saccharin.pdf |
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