Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach
The paper focuses on the design of a biochip for Single Cell Analysis (SCA) using microfluidics. Several techniques have been developed for analysis of human cells. But most of these analyses are done on a group of cells assuming that all the cells within an isogenic cell population are homogenous....
| Autors principals: | , , , , |
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| Format: | Conference or Workshop Item |
| Idioma: | English |
| Publicat: |
IEEE
2017
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| Matèries: | |
| Accés en línia: | http://umpir.ump.edu.my/id/eprint/23060/1/Microfluidic%20micro-well%20%28size%20and%20shape%29%20by%20numerical%20optimization%20for%20single%20cell%20applications.pdf |
| _version_ | 1825812385618722816 |
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| author | James, Jasper A. M., Sushmitha R., Premkumar Narayanamurthy, Vigneswaran R., Kalpana |
| author_facet | James, Jasper A. M., Sushmitha R., Premkumar Narayanamurthy, Vigneswaran R., Kalpana |
| author_sort | James, Jasper A. |
| collection | UMP |
| description | The paper focuses on the design of a biochip for Single Cell Analysis (SCA) using microfluidics. Several techniques have been developed for analysis of human cells. But most of these analyses are done on a group of cells assuming that all the cells within an isogenic cell population are homogenous. However, many evidences show that cellular heterogeneity occurs even within an isogenic cell population. Therefore, single cell analysis has been gaining a lot of importance in the recent past. The main objective is to design a micro-well with vertical trapping. The focus is on capturing a single cell by optimizing the shape and size of the micro-well and microchannel using hydrodynamics. The design simulation is done using COMSOL Multiphysics software. The paper provides a comparative analysis of various designs proposed, based on their performance and design parameters. |
| first_indexed | 2024-03-06T12:28:22Z |
| format | Conference or Workshop Item |
| id | UMPir23060 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:28:22Z |
| publishDate | 2017 |
| publisher | IEEE |
| record_format | dspace |
| spelling | UMPir230602019-04-22T02:08:31Z http://umpir.ump.edu.my/id/eprint/23060/ Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach James, Jasper A. M., Sushmitha R., Premkumar Narayanamurthy, Vigneswaran R., Kalpana TK Electrical engineering. Electronics Nuclear engineering The paper focuses on the design of a biochip for Single Cell Analysis (SCA) using microfluidics. Several techniques have been developed for analysis of human cells. But most of these analyses are done on a group of cells assuming that all the cells within an isogenic cell population are homogenous. However, many evidences show that cellular heterogeneity occurs even within an isogenic cell population. Therefore, single cell analysis has been gaining a lot of importance in the recent past. The main objective is to design a micro-well with vertical trapping. The focus is on capturing a single cell by optimizing the shape and size of the micro-well and microchannel using hydrodynamics. The design simulation is done using COMSOL Multiphysics software. The paper provides a comparative analysis of various designs proposed, based on their performance and design parameters. IEEE 2017 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23060/1/Microfluidic%20micro-well%20%28size%20and%20shape%29%20by%20numerical%20optimization%20for%20single%20cell%20applications.pdf James, Jasper A. and M., Sushmitha and R., Premkumar and Narayanamurthy, Vigneswaran and R., Kalpana (2017) Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach. In: International Conference on Microelectronic Devices, Circuits and Systems (ICMDCS 2017) , 10-12 August 2017 , Vellore, India. pp. 1-6.. ISBN 978-1-5386-1716-8 (Published) https://ieeexplore.ieee.org/abstract/document/8211597 https://doi.org/10.1016/j.ijrefrig.2018.01.015 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering James, Jasper A. M., Sushmitha R., Premkumar Narayanamurthy, Vigneswaran R., Kalpana Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach |
| title | Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach |
| title_full | Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach |
| title_fullStr | Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach |
| title_full_unstemmed | Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach |
| title_short | Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach |
| title_sort | microfluidic micro well size and shape by numerical optimization for single cell applications vertical trapping approach |
| topic | TK Electrical engineering. Electronics Nuclear engineering |
| url | http://umpir.ump.edu.my/id/eprint/23060/1/Microfluidic%20micro-well%20%28size%20and%20shape%29%20by%20numerical%20optimization%20for%20single%20cell%20applications.pdf |
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