Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactant...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf |
| _version_ | 1825812528449454080 |
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| author | Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem |
| author_facet | Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem |
| author_sort | Rashid, Muhammad Abid |
| collection | UMP |
| description | This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactants tween 20/60, 1-propanol and phosphate buffer. The optimum weight ratios of components and MEs areas were determined by pseudo-ternary phase diagram. All formulations were physically characterized by centrifugation, pH, refractive index, conductivity, viscosity, surface tension and partition coefficient. The specific residence site of chloramphenicol was detected by 1H NMR study. It was uncovered that drug is entrapped between the oxyethylene groups of hydrophilic shell of MEs. So, the drug was screened from bulk water and its stability was enhanced. Thus, all characterizations have suggested that formulated MEs have potential for ocular application, being able to use as efficient drug carrier for ocular drug delivery. |
| first_indexed | 2024-03-06T12:30:31Z |
| format | Article |
| id | UMPir23931 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:30:31Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | UMPir239312019-01-23T08:21:16Z http://umpir.ump.edu.my/id/eprint/23931/ Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem QR Microbiology This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactants tween 20/60, 1-propanol and phosphate buffer. The optimum weight ratios of components and MEs areas were determined by pseudo-ternary phase diagram. All formulations were physically characterized by centrifugation, pH, refractive index, conductivity, viscosity, surface tension and partition coefficient. The specific residence site of chloramphenicol was detected by 1H NMR study. It was uncovered that drug is entrapped between the oxyethylene groups of hydrophilic shell of MEs. So, the drug was screened from bulk water and its stability was enhanced. Thus, all characterizations have suggested that formulated MEs have potential for ocular application, being able to use as efficient drug carrier for ocular drug delivery. Elsevier 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf Rashid, Muhammad Abid and Naza, Tehreem and Abbas, Madeeha and Nazir, Sadia and Younas, Nafisa and Majeed, Sana and Qureshi, Naseem and Akhtar, Muhammad Nadeem (2019) Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability. Colloid and Interface Science Communications, 28. pp. 41-48. ISSN 2215-0382. (Published) https://doi.org/10.1016/j.colcom.2018.11.006 https://doi.org/10.1016/j.colcom.2018.11.006 |
| spellingShingle | QR Microbiology Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability |
| title | Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability |
| title_full | Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability |
| title_fullStr | Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability |
| title_full_unstemmed | Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability |
| title_short | Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability |
| title_sort | chloramphenicol loaded microemulsions development characterization and stability |
| topic | QR Microbiology |
| url | http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf |
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