Freeze-dried lopinavir-loaded nanostructured lipid carriers for enhanced cellular uptake and bioavailability: statistical optimization, in vitro and in vivo evaluations.
Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-shear homogenization method. The LPV-NLCs formulations were freeze-dried using trehalose as a cryoprotectant. In vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI
2019
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/24708/1/Freeze-Dried%20Lopinavir-Loaded%20Nanostructured%20Lipid%20Carriers%20for%20Enhanced%20Cellular.pdf |