Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro

The kava-kava plant (Piper methsyticum) is traditionally known as the pacific elixir by the pacific islanders for its role in a wide range of biological activities. The extract of the roots of this plant contains a variety of interesting molecules including Flavokawain A and this molecule is known t...

Full description

Bibliographic Details
Main Authors: Nadiah, Abu, M. Nadeem, Akhtar, Yeap, Swee Keong, Lim, Kian Lam, Ho, Wan Yong, Aimi Jamil, Zulfadli, Abdul Rahman, Omar, Mohd Roslan, Sulaiman, Mohd Puad, Abdullah, Noorjahan Banu, Alitheen
Format: Article
Language:English
Published: Public Library of Science 2014
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/25416/1/Flavokawain%20a%20induces%20apoptosis%20in%20MCF-7%20and%20MDA-MB231.PDF
_version_ 1796993462233464832
author Nadiah, Abu
M. Nadeem, Akhtar
Yeap, Swee Keong
Lim, Kian Lam
Ho, Wan Yong
Aimi Jamil, Zulfadli
Abdul Rahman, Omar
Mohd Roslan, Sulaiman
Mohd Puad, Abdullah
Noorjahan Banu, Alitheen
author_facet Nadiah, Abu
M. Nadeem, Akhtar
Yeap, Swee Keong
Lim, Kian Lam
Ho, Wan Yong
Aimi Jamil, Zulfadli
Abdul Rahman, Omar
Mohd Roslan, Sulaiman
Mohd Puad, Abdullah
Noorjahan Banu, Alitheen
author_sort Nadiah, Abu
collection UMP
description The kava-kava plant (Piper methsyticum) is traditionally known as the pacific elixir by the pacific islanders for its role in a wide range of biological activities. The extract of the roots of this plant contains a variety of interesting molecules including Flavokawain A and this molecule is known to have anti-cancer properties. Breast cancer is still one of the leading diagnosed cancers in women today. The metastatic process is also very pertinent in the progression of tumorigenesis.
first_indexed 2024-03-06T12:34:20Z
format Article
id UMPir25416
institution Universiti Malaysia Pahang
language English
last_indexed 2024-03-06T12:34:20Z
publishDate 2014
publisher Public Library of Science
record_format dspace
spelling UMPir254162019-07-18T02:37:47Z http://umpir.ump.edu.my/id/eprint/25416/ Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro Nadiah, Abu M. Nadeem, Akhtar Yeap, Swee Keong Lim, Kian Lam Ho, Wan Yong Aimi Jamil, Zulfadli Abdul Rahman, Omar Mohd Roslan, Sulaiman Mohd Puad, Abdullah Noorjahan Banu, Alitheen Q Science (General) The kava-kava plant (Piper methsyticum) is traditionally known as the pacific elixir by the pacific islanders for its role in a wide range of biological activities. The extract of the roots of this plant contains a variety of interesting molecules including Flavokawain A and this molecule is known to have anti-cancer properties. Breast cancer is still one of the leading diagnosed cancers in women today. The metastatic process is also very pertinent in the progression of tumorigenesis. Public Library of Science 2014 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25416/1/Flavokawain%20a%20induces%20apoptosis%20in%20MCF-7%20and%20MDA-MB231.PDF Nadiah, Abu and M. Nadeem, Akhtar and Yeap, Swee Keong and Lim, Kian Lam and Ho, Wan Yong and Aimi Jamil, Zulfadli and Abdul Rahman, Omar and Mohd Roslan, Sulaiman and Mohd Puad, Abdullah and Noorjahan Banu, Alitheen (2014) Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro. PLoS ONE, 9 (10). pp. 1-12. ISSN 1932-6203. (Published) https://doi.org/10.1371/journal.pone.0105244 https://doi.org/10.1371/journal.pone.0105244
spellingShingle Q Science (General)
Nadiah, Abu
M. Nadeem, Akhtar
Yeap, Swee Keong
Lim, Kian Lam
Ho, Wan Yong
Aimi Jamil, Zulfadli
Abdul Rahman, Omar
Mohd Roslan, Sulaiman
Mohd Puad, Abdullah
Noorjahan Banu, Alitheen
Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
title Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
title_full Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
title_fullStr Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
title_full_unstemmed Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
title_short Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
title_sort flavokawain a induces apoptosis in mcf 7 and mda mb231 and inhibits the metastatic process in vitro
topic Q Science (General)
url http://umpir.ump.edu.my/id/eprint/25416/1/Flavokawain%20a%20induces%20apoptosis%20in%20MCF-7%20and%20MDA-MB231.PDF
work_keys_str_mv AT nadiahabu flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT mnadeemakhtar flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT yeapsweekeong flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT limkianlam flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT howanyong flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT aimijamilzulfadli flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT abdulrahmanomar flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT mohdroslansulaiman flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT mohdpuadabdullah flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro
AT noorjahanbanualitheen flavokawainainducesapoptosisinmcf7andmdamb231andinhibitsthemetastaticprocessinvitro