POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata
In this study, a central composite design was employed to optimize the process variables, i.e., microwave power (75-175 W) and ethanol concentration (20-85%) on the yield of bioactive compound extraction from Andrographis paniculata. The regression analysis shows a good fit between the experimental...
| Main Authors: | , , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
University of Nottingham
2019
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/26833/1/POCER1915_Microwave-Assisted%20Extraction1.pdf |
| _version_ | 1825813052667199488 |
|---|---|
| author | Chia, Vi Vien Pang, Sook Fun Sureena, Abdullah M. M., Yusoff Jolius, Gimbun |
| author_facet | Chia, Vi Vien Pang, Sook Fun Sureena, Abdullah M. M., Yusoff Jolius, Gimbun |
| author_sort | Chia, Vi Vien |
| collection | UMP |
| description | In this study, a central composite design was employed to optimize the process variables, i.e., microwave power (75-175 W) and ethanol concentration (20-85%) on the yield of bioactive compound extraction from Andrographis paniculata. The regression analysis shows a good fit between the experimental data to the second-order polynomial model with a coefficient of determination (R2) value of ≈ 0.95. The optimum conditions to maximize the yield of andrographolide, 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide were found at microwave power of 140 W and 85% ethanol. Experimental validation performed at the aforementioned conditions yielded AND (10.93 ± 0.053 mg/gDW), DDA (4.34 ± 0.215 mg/gDW), and NEA (5.70 ± 0.252 mg/gDW), which are comparable to those of
model prediction, i.e., 10.426 mg/gDW of AND, 4.123 mg/gDW of DDA and 5.558 mg/gDW of NEA, indicating the suitability of the developed models. |
| first_indexed | 2024-03-06T12:38:18Z |
| format | Conference or Workshop Item |
| id | UMPir26833 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:38:18Z |
| publishDate | 2019 |
| publisher | University of Nottingham |
| record_format | dspace |
| spelling | UMPir268332019-12-16T08:01:14Z http://umpir.ump.edu.my/id/eprint/26833/ POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata Chia, Vi Vien Pang, Sook Fun Sureena, Abdullah M. M., Yusoff Jolius, Gimbun TP Chemical technology In this study, a central composite design was employed to optimize the process variables, i.e., microwave power (75-175 W) and ethanol concentration (20-85%) on the yield of bioactive compound extraction from Andrographis paniculata. The regression analysis shows a good fit between the experimental data to the second-order polynomial model with a coefficient of determination (R2) value of ≈ 0.95. The optimum conditions to maximize the yield of andrographolide, 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide were found at microwave power of 140 W and 85% ethanol. Experimental validation performed at the aforementioned conditions yielded AND (10.93 ± 0.053 mg/gDW), DDA (4.34 ± 0.215 mg/gDW), and NEA (5.70 ± 0.252 mg/gDW), which are comparable to those of model prediction, i.e., 10.426 mg/gDW of AND, 4.123 mg/gDW of DDA and 5.558 mg/gDW of NEA, indicating the suitability of the developed models. University of Nottingham 2019 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26833/1/POCER1915_Microwave-Assisted%20Extraction1.pdf Chia, Vi Vien and Pang, Sook Fun and Sureena, Abdullah and M. M., Yusoff and Jolius, Gimbun (2019) POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata. In: Proceedings of the 5th Postgraduate Colloquium for Environmental Research (POCER 2019) , 8-9 August 2019 , Putrajaya, Malaysia. pp. 39-41., 8. ISBN 978-967-11279-6-4 (Published) https://www.nottingham.edu.my/Conferences/POCER/News-and-Proceedings.aspx |
| spellingShingle | TP Chemical technology Chia, Vi Vien Pang, Sook Fun Sureena, Abdullah M. M., Yusoff Jolius, Gimbun POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata |
| title | POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata |
| title_full | POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata |
| title_fullStr | POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata |
| title_full_unstemmed | POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata |
| title_short | POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata |
| title_sort | pocer 1915 microwave assisted extraction of andrographolide 14 deoxy 11 12 didehydroandrographolide and neoandrographolide from andrographis paniculata |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/26833/1/POCER1915_Microwave-Assisted%20Extraction1.pdf |
| work_keys_str_mv | AT chiavivien pocer1915microwaveassistedextractionofandrographolide14deoxy1112didehydroandrographolideandneoandrographolidefromandrographispaniculata AT pangsookfun pocer1915microwaveassistedextractionofandrographolide14deoxy1112didehydroandrographolideandneoandrographolidefromandrographispaniculata AT sureenaabdullah pocer1915microwaveassistedextractionofandrographolide14deoxy1112didehydroandrographolideandneoandrographolidefromandrographispaniculata AT mmyusoff pocer1915microwaveassistedextractionofandrographolide14deoxy1112didehydroandrographolideandneoandrographolidefromandrographispaniculata AT joliusgimbun pocer1915microwaveassistedextractionofandrographolide14deoxy1112didehydroandrographolideandneoandrographolidefromandrographispaniculata |