Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning
This paper presents the effect of humidity on electrospun polycaprolactone (PCL) nanofiber formation using needleless electrospinning for drug delivery application. The nanofiber was made using a NS Lab needleless electrospinning working at the applied voltage of 45 kV. Polycaprolactone in dichlorom...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2019
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/27510/1/Effect%20of%20Humidity%20on%20Formation%20of%20Electrospun1.pdf |
| _version_ | 1796993890539012096 |
|---|---|
| author | Ramakrishnan, Ramprasath Ramakrishnan, Praveena Ranganathan, Balu Tan, Cowen Sridhar, T. M. Jolius, Gimbun |
| author_facet | Ramakrishnan, Ramprasath Ramakrishnan, Praveena Ranganathan, Balu Tan, Cowen Sridhar, T. M. Jolius, Gimbun |
| author_sort | Ramakrishnan, Ramprasath |
| collection | UMP |
| description | This paper presents the effect of humidity on electrospun polycaprolactone (PCL) nanofiber formation using needleless electrospinning for drug delivery application. The nanofiber was made using a NS Lab needleless electrospinning working at the applied voltage of 45 kV. Polycaprolactone in dichloromethane was the polymer used with curcumin as the embedding model drug. Morphology of the fiber was analyzed using scanning electron microscopy and the fiber size distribution was studied using Fiber Metric image analysis tool. An increase in fiber diameter from 100 nm to 145 nm was observed when the humidity factor was raised from 40 RH to 60 RH. The fibers produced are also much more uniform at 60 humidity. The model drug, curcumin was loaded into a PCL nanofiber with entrapment efficiency up to 93. The controlled release of curcumin from the scaffold under physiological simulated conditions shows a significant release of curcumin within 48 hours of test. This work may serve as a useful guide to obtain a high-quality nanofiber from needleless electrospinning process for drug delivery application. |
| first_indexed | 2024-03-06T12:40:13Z |
| format | Article |
| id | UMPir27510 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:40:13Z |
| publishDate | 2019 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | UMPir275102020-03-27T09:07:27Z http://umpir.ump.edu.my/id/eprint/27510/ Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning Ramakrishnan, Ramprasath Ramakrishnan, Praveena Ranganathan, Balu Tan, Cowen Sridhar, T. M. Jolius, Gimbun TP Chemical technology This paper presents the effect of humidity on electrospun polycaprolactone (PCL) nanofiber formation using needleless electrospinning for drug delivery application. The nanofiber was made using a NS Lab needleless electrospinning working at the applied voltage of 45 kV. Polycaprolactone in dichloromethane was the polymer used with curcumin as the embedding model drug. Morphology of the fiber was analyzed using scanning electron microscopy and the fiber size distribution was studied using Fiber Metric image analysis tool. An increase in fiber diameter from 100 nm to 145 nm was observed when the humidity factor was raised from 40 RH to 60 RH. The fibers produced are also much more uniform at 60 humidity. The model drug, curcumin was loaded into a PCL nanofiber with entrapment efficiency up to 93. The controlled release of curcumin from the scaffold under physiological simulated conditions shows a significant release of curcumin within 48 hours of test. This work may serve as a useful guide to obtain a high-quality nanofiber from needleless electrospinning process for drug delivery application. Elsevier Ltd 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/27510/1/Effect%20of%20Humidity%20on%20Formation%20of%20Electrospun1.pdf Ramakrishnan, Ramprasath and Ramakrishnan, Praveena and Ranganathan, Balu and Tan, Cowen and Sridhar, T. M. and Jolius, Gimbun (2019) Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning. Materials Today: Proceedings, 19. 1241 - 1246. ISSN 2214-7853. (Published) https://doi.org/10.1016/j.matpr.2019.11.128 https://doi.org/10.1016/j.matpr.2019.11.128 |
| spellingShingle | TP Chemical technology Ramakrishnan, Ramprasath Ramakrishnan, Praveena Ranganathan, Balu Tan, Cowen Sridhar, T. M. Jolius, Gimbun Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning |
| title | Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning |
| title_full | Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning |
| title_fullStr | Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning |
| title_full_unstemmed | Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning |
| title_short | Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning |
| title_sort | effect of humidity on formation of electrospun polycaprolactone nanofiber embedded with curcumin using needdleless electrospinning |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/27510/1/Effect%20of%20Humidity%20on%20Formation%20of%20Electrospun1.pdf |
| work_keys_str_mv | AT ramakrishnanramprasath effectofhumidityonformationofelectrospunpolycaprolactonenanofiberembeddedwithcurcuminusingneeddlelesselectrospinning AT ramakrishnanpraveena effectofhumidityonformationofelectrospunpolycaprolactonenanofiberembeddedwithcurcuminusingneeddlelesselectrospinning AT ranganathanbalu effectofhumidityonformationofelectrospunpolycaprolactonenanofiberembeddedwithcurcuminusingneeddlelesselectrospinning AT tancowen effectofhumidityonformationofelectrospunpolycaprolactonenanofiberembeddedwithcurcuminusingneeddlelesselectrospinning AT sridhartm effectofhumidityonformationofelectrospunpolycaprolactonenanofiberembeddedwithcurcuminusingneeddlelesselectrospinning AT joliusgimbun effectofhumidityonformationofelectrospunpolycaprolactonenanofiberembeddedwithcurcuminusingneeddlelesselectrospinning |