Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction
Reverse micellar extraction (RME) has emerged as a versatile and efficient tool for downstream processing (DSP) of various biomolecules, including structural proteins and enzymes, due to the substantial advantages over conventional DSP methods. However, the RME system is a complex dependency of seve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor and Francis Ltd
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/28046/1/Application%20of%20experimental%20designs%20and%20response%20surface%20methods%20.pdf |
| _version_ | 1825813282360918016 |
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| author | Sharifah Fathiyah, Sy Mohamad Farhan, Mohd Said Mimi Sakinah, A. M. Shahril, Mohamad Wan Mohd Azizi, Wan Sulaiman |
| author_facet | Sharifah Fathiyah, Sy Mohamad Farhan, Mohd Said Mimi Sakinah, A. M. Shahril, Mohamad Wan Mohd Azizi, Wan Sulaiman |
| author_sort | Sharifah Fathiyah, Sy Mohamad |
| collection | UMP |
| description | Reverse micellar extraction (RME) has emerged as a versatile and efficient tool for downstream processing (DSP) of various biomolecules, including structural proteins and enzymes, due to the substantial advantages over conventional DSP methods. However, the RME system is a complex dependency of several parameters that influences the overall selectivity and performance of the RME system, hence this justifies the need for optimization to obtain higher possible extraction results. For the last two decades, many experimental design strategies for screening and optimization of RME have been described in literature. The objective of this article is to review the use of different experimental designs and response surface methodologies that are currently used to screen and optimize the RME system for various types of biomolecules. Overall, this review provides the rationale for the selection of appropriate screening or optimization techniques for the parameters associated with both forward and backward extraction during the RME of biomolecules. |
| first_indexed | 2024-03-06T12:41:40Z |
| format | Article |
| id | UMPir28046 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:41:40Z |
| publishDate | 2020 |
| publisher | Taylor and Francis Ltd |
| record_format | dspace |
| spelling | UMPir280462021-01-18T08:28:12Z http://umpir.ump.edu.my/id/eprint/28046/ Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction Sharifah Fathiyah, Sy Mohamad Farhan, Mohd Said Mimi Sakinah, A. M. Shahril, Mohamad Wan Mohd Azizi, Wan Sulaiman TP Chemical technology Reverse micellar extraction (RME) has emerged as a versatile and efficient tool for downstream processing (DSP) of various biomolecules, including structural proteins and enzymes, due to the substantial advantages over conventional DSP methods. However, the RME system is a complex dependency of several parameters that influences the overall selectivity and performance of the RME system, hence this justifies the need for optimization to obtain higher possible extraction results. For the last two decades, many experimental design strategies for screening and optimization of RME have been described in literature. The objective of this article is to review the use of different experimental designs and response surface methodologies that are currently used to screen and optimize the RME system for various types of biomolecules. Overall, this review provides the rationale for the selection of appropriate screening or optimization techniques for the parameters associated with both forward and backward extraction during the RME of biomolecules. Taylor and Francis Ltd 2020 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/28046/1/Application%20of%20experimental%20designs%20and%20response%20surface%20methods%20.pdf Sharifah Fathiyah, Sy Mohamad and Farhan, Mohd Said and Mimi Sakinah, A. M. and Shahril, Mohamad and Wan Mohd Azizi, Wan Sulaiman (2020) Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction. Critical Reviews in Biotechnology, 40 (3). pp. 341-356. ISSN 0738-8551. (Published) https://doi.org/10.1080/07388551.2020.1712321 https://doi.org/10.1080/07388551.2020.1712321 |
| spellingShingle | TP Chemical technology Sharifah Fathiyah, Sy Mohamad Farhan, Mohd Said Mimi Sakinah, A. M. Shahril, Mohamad Wan Mohd Azizi, Wan Sulaiman Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction |
| title | Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction |
| title_full | Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction |
| title_fullStr | Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction |
| title_full_unstemmed | Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction |
| title_short | Application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction |
| title_sort | application of experimental designs and response surface methods in screening and optimization of reverse micellar extraction |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/28046/1/Application%20of%20experimental%20designs%20and%20response%20surface%20methods%20.pdf |
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