Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium
At present, vegetarian hard capsules from hydroxypropyl methyl cellulose is highly attractive to consumer market. However, the production volume is still low due to expensive raw polymer materials. Most of the renewable polymers do not meet sufficient mechanical strength for developing hard capsules...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier B.V.
2021
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| Online Access: | http://umpir.ump.edu.my/id/eprint/28759/1/35.%20Tuning%20mechanical%20properties%20of%20seaweeds%20for%20hard%20capsules.pdf http://umpir.ump.edu.my/id/eprint/28759/8/Tuning%20mechanical%20properties%20of%20seaweeds.pdf |
| _version_ | 1796994132983414784 |
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| author | Mohd Aiman, Hamdan Khairatun Najwa, Mohd Amin Rajan, Jose Martin, Darren Fatmawati, Adam |
| author_facet | Mohd Aiman, Hamdan Khairatun Najwa, Mohd Amin Rajan, Jose Martin, Darren Fatmawati, Adam |
| author_sort | Mohd Aiman, Hamdan |
| collection | UMP |
| description | At present, vegetarian hard capsules from hydroxypropyl methyl cellulose is highly attractive to consumer market. However, the production volume is still low due to expensive raw polymer materials. Most of the renewable polymers do not meet sufficient mechanical strength for developing hard capsules. This work demonstrates that the mechanical properties of carrageenan, a sea-based edible material known as seaweeds, could be enhanced by the addition of small amounts (<2 wt./v%) of cellulose nanocrystals (CNC) for developing hard capsules. The microstructure and mechanical properties of the cellulose toughened carrageenan films are systematically correlated to the rheology of the solution from which the films were prepared. Carrageenan films containing 1.6 wt./v% of CNC showed an optimum viscosity of 1.17 mPas with 58% higher tensile strength than films without CNC. The hard capsules thereby developed are stable to three types of antibiotics, which are amoxycillin 500 mg, ampicillin 500 mg, and doxycycline 100 mg. The carrageenan biocomposite hard capsule is suitable for human consumption based on the cytotoxicity test on human body. All the hard capsule samples showed excellent disintegration behavior in physiological conditions. These achievements pose promising directions for sustainable materials supply for pharmaceutical industries. |
| first_indexed | 2024-03-06T12:43:35Z |
| format | Article |
| id | UMPir28759 |
| institution | Universiti Malaysia Pahang |
| language | English English |
| last_indexed | 2024-03-06T12:43:35Z |
| publishDate | 2021 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | UMPir287592021-09-01T01:38:59Z http://umpir.ump.edu.my/id/eprint/28759/ Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium Mohd Aiman, Hamdan Khairatun Najwa, Mohd Amin Rajan, Jose Martin, Darren Fatmawati, Adam TP Chemical technology At present, vegetarian hard capsules from hydroxypropyl methyl cellulose is highly attractive to consumer market. However, the production volume is still low due to expensive raw polymer materials. Most of the renewable polymers do not meet sufficient mechanical strength for developing hard capsules. This work demonstrates that the mechanical properties of carrageenan, a sea-based edible material known as seaweeds, could be enhanced by the addition of small amounts (<2 wt./v%) of cellulose nanocrystals (CNC) for developing hard capsules. The microstructure and mechanical properties of the cellulose toughened carrageenan films are systematically correlated to the rheology of the solution from which the films were prepared. Carrageenan films containing 1.6 wt./v% of CNC showed an optimum viscosity of 1.17 mPas with 58% higher tensile strength than films without CNC. The hard capsules thereby developed are stable to three types of antibiotics, which are amoxycillin 500 mg, ampicillin 500 mg, and doxycycline 100 mg. The carrageenan biocomposite hard capsule is suitable for human consumption based on the cytotoxicity test on human body. All the hard capsule samples showed excellent disintegration behavior in physiological conditions. These achievements pose promising directions for sustainable materials supply for pharmaceutical industries. Elsevier B.V. 2021 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/28759/1/35.%20Tuning%20mechanical%20properties%20of%20seaweeds%20for%20hard%20capsules.pdf pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/28759/8/Tuning%20mechanical%20properties%20of%20seaweeds.pdf Mohd Aiman, Hamdan and Khairatun Najwa, Mohd Amin and Rajan, Jose and Martin, Darren and Fatmawati, Adam (2021) Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium. Food Hydrocolloids for Health, 1 (100023). pp. 1-10. ISSN 2667-0259. (Published) https://doi.org/10.1016/j.fhfh.2021.100023 https://doi.org/10.1016/j.fhfh.2021.100023 |
| spellingShingle | TP Chemical technology Mohd Aiman, Hamdan Khairatun Najwa, Mohd Amin Rajan, Jose Martin, Darren Fatmawati, Adam Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium |
| title | Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium |
| title_full | Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium |
| title_fullStr | Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium |
| title_full_unstemmed | Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium |
| title_short | Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium |
| title_sort | tuning mechanical properties of seaweeds for hard capsules a step forward for a sustainable drug delivery medium |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/28759/1/35.%20Tuning%20mechanical%20properties%20of%20seaweeds%20for%20hard%20capsules.pdf http://umpir.ump.edu.my/id/eprint/28759/8/Tuning%20mechanical%20properties%20of%20seaweeds.pdf |
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