Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production
Computational method can be used for investigation of the protein sequences for developing a vaccine against infections. In this present study, a protein derived from non-O157 Verotoxin-producing E. coli (VTEC) was identified as a potential vaccine candidate that can be used to evaluate their immuno...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
IEEE
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29304/13/Computational%20Investigation%20on%20Protein%20Sequence.pdf |
| _version_ | 1825813498366525440 |
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| author | Karim Khan, Md Fazlul Kabir, M. Nomani Rashid, Shah Samiur Tayan, Omar Mohammad Nazmul Hasan, Maziz |
| author_facet | Karim Khan, Md Fazlul Kabir, M. Nomani Rashid, Shah Samiur Tayan, Omar Mohammad Nazmul Hasan, Maziz |
| author_sort | Karim Khan, Md Fazlul |
| collection | UMP |
| description | Computational method can be used for investigation of the protein sequences for developing a vaccine against infections. In this present study, a protein derived from non-O157 Verotoxin-producing E. coli (VTEC) was identified as a potential vaccine candidate that can be used to evaluate their immunogenicity and protective capability against VTEC infections. Identification of potential B-cell epitopes for promising vaccine was carried out by evaluating the protein derived from non-O157 VTEC with the methods of beta turns, hydropathicity, surface accessibility and antigenicity. The methods were implemented in MATLAB. Our test results demonstrated that the VTEC-derived protein has plausible characteristics which provide significant insights for further investigations and will assist in finding potential drug targets/vaccine candidates. |
| first_indexed | 2024-03-06T12:44:54Z |
| format | Conference or Workshop Item |
| id | UMPir29304 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:44:54Z |
| publishDate | 2020 |
| publisher | IEEE |
| record_format | dspace |
| spelling | UMPir293042022-12-13T07:49:30Z http://umpir.ump.edu.my/id/eprint/29304/ Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production Karim Khan, Md Fazlul Kabir, M. Nomani Rashid, Shah Samiur Tayan, Omar Mohammad Nazmul Hasan, Maziz QA75 Electronic computers. Computer science Computational method can be used for investigation of the protein sequences for developing a vaccine against infections. In this present study, a protein derived from non-O157 Verotoxin-producing E. coli (VTEC) was identified as a potential vaccine candidate that can be used to evaluate their immunogenicity and protective capability against VTEC infections. Identification of potential B-cell epitopes for promising vaccine was carried out by evaluating the protein derived from non-O157 VTEC with the methods of beta turns, hydropathicity, surface accessibility and antigenicity. The methods were implemented in MATLAB. Our test results demonstrated that the VTEC-derived protein has plausible characteristics which provide significant insights for further investigations and will assist in finding potential drug targets/vaccine candidates. IEEE 2020 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/29304/13/Computational%20Investigation%20on%20Protein%20Sequence.pdf Karim Khan, Md Fazlul and Kabir, M. Nomani and Rashid, Shah Samiur and Tayan, Omar and Mohammad Nazmul Hasan, Maziz (2020) Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production. In: IEEE International Conference on Automatic Control and Intelligent Systems (I2CACIS 2020) , 20-20 June 2020 , Shah Alam, Selangor, Malaysia. pp. 57-61.. ISBN 978-1-7281-6133-4 (Published) https://doi.org/10.1109/I2CACIS49202.2020.9140202 doi:10.1109/I2CACIS49202.2020.9140202 |
| spellingShingle | QA75 Electronic computers. Computer science Karim Khan, Md Fazlul Kabir, M. Nomani Rashid, Shah Samiur Tayan, Omar Mohammad Nazmul Hasan, Maziz Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production |
| title | Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production |
| title_full | Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production |
| title_fullStr | Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production |
| title_full_unstemmed | Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production |
| title_short | Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production |
| title_sort | computational investigation on protein sequence of non o157 vtec for potentiality of vaccine production |
| topic | QA75 Electronic computers. Computer science |
| url | http://umpir.ump.edu.my/id/eprint/29304/13/Computational%20Investigation%20on%20Protein%20Sequence.pdf |
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