In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides
Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29984/1/In%20silico%20analysis%20of%20the%20antigenic%20properties%20of%20iron.pdf |
| _version_ | 1796994347458101248 |
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| author | Rahman, Md. Shahedur Biswas, Chayon Biswas, Polash Kumar Kader, Md. Ashraful Nur Alam, S. M. Sonne, Christian Kim, Ki-Hyun |
| author_facet | Rahman, Md. Shahedur Biswas, Chayon Biswas, Polash Kumar Kader, Md. Ashraful Nur Alam, S. M. Sonne, Christian Kim, Ki-Hyun |
| author_sort | Rahman, Md. Shahedur |
| collection | UMP |
| description | Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal for N. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine against N. meningitidis. The basic properties of N. meningitidis OMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine against N. meningitidis both in vitro and in vivo. |
| first_indexed | 2024-03-06T12:46:33Z |
| format | Article |
| id | UMPir29984 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:46:33Z |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | dspace |
| spelling | UMPir299842022-06-21T02:00:37Z http://umpir.ump.edu.my/id/eprint/29984/ In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides Rahman, Md. Shahedur Biswas, Chayon Biswas, Polash Kumar Kader, Md. Ashraful Nur Alam, S. M. Sonne, Christian Kim, Ki-Hyun TP Chemical technology Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal for N. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine against N. meningitidis. The basic properties of N. meningitidis OMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine against N. meningitidis both in vitro and in vivo. MDPI 2020-09 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/29984/1/In%20silico%20analysis%20of%20the%20antigenic%20properties%20of%20iron.pdf Rahman, Md. Shahedur and Biswas, Chayon and Biswas, Polash Kumar and Kader, Md. Ashraful and Nur Alam, S. M. and Sonne, Christian and Kim, Ki-Hyun (2020) In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides. Applied Sciences, 10 (17). pp. 1-12. ISSN 2076-3417. (Published) https://doi.org/10.3390/app10176113 https://doi.org/10.3390/app10176113 |
| spellingShingle | TP Chemical technology Rahman, Md. Shahedur Biswas, Chayon Biswas, Polash Kumar Kader, Md. Ashraful Nur Alam, S. M. Sonne, Christian Kim, Ki-Hyun In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides |
| title | In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides |
| title_full | In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides |
| title_fullStr | In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides |
| title_full_unstemmed | In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides |
| title_short | In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides |
| title_sort | in silico analysis of the antigenic properties of iron regulated proteins against neisseria meningitides |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/29984/1/In%20silico%20analysis%20of%20the%20antigenic%20properties%20of%20iron.pdf |
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