Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
In this study, a simplex-centroid mixture design using design of experiment (DOE) software was implemented to evaluate the effect of biopolymers as excipients, which are hydroxypropyl methylcellulose, and alginate, on the gastrointestinal tolerance of probiotic tablet containing Saccharomyces boular...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/30455/1/azhar2020.pdf |
| _version_ | 1825813687327260672 |
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| author | Mohd Akmal, Azhar Mimi Sakinah, Abdul Munaim |
| author_facet | Mohd Akmal, Azhar Mimi Sakinah, Abdul Munaim |
| author_sort | Mohd Akmal, Azhar |
| collection | UMP |
| description | In this study, a simplex-centroid mixture design using design of experiment (DOE) software was implemented to evaluate the effect of biopolymers as excipients, which are hydroxypropyl methylcellulose, and alginate, on the gastrointestinal tolerance of probiotic tablet containing Saccharomyces boulardii. Microbial viability and dissolution time were used to evaluate the ideal formulation made using 39.01% carboxymethylcellulose and 60.99% alginate as excipients, which protected the probiotics from the acidic condition in the stomach with good dissolution time. The formulated probiotic tablet is more stable in terms of viability when stored at 4 C compared to room temperature. However, the viability remains above 106 CFU/tablet after six months of storage at room temperature. This study shows that the simplex-centroid mixture design is valid and can be used to formulate probiotic tablets that possess gastrointestinal tolerance. This study can lead to the development of commercial production of probiotic yeast tablets with gastrointestinal tolerance. |
| first_indexed | 2024-03-06T12:47:43Z |
| format | Article |
| id | UMPir30455 |
| institution | Universiti Malaysia Pahang |
| language | English |
| last_indexed | 2024-03-06T12:47:43Z |
| publishDate | 2020 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | UMPir304552021-01-15T04:06:19Z http://umpir.ump.edu.my/id/eprint/30455/ Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. Mohd Akmal, Azhar Mimi Sakinah, Abdul Munaim TP Chemical technology In this study, a simplex-centroid mixture design using design of experiment (DOE) software was implemented to evaluate the effect of biopolymers as excipients, which are hydroxypropyl methylcellulose, and alginate, on the gastrointestinal tolerance of probiotic tablet containing Saccharomyces boulardii. Microbial viability and dissolution time were used to evaluate the ideal formulation made using 39.01% carboxymethylcellulose and 60.99% alginate as excipients, which protected the probiotics from the acidic condition in the stomach with good dissolution time. The formulated probiotic tablet is more stable in terms of viability when stored at 4 C compared to room temperature. However, the viability remains above 106 CFU/tablet after six months of storage at room temperature. This study shows that the simplex-centroid mixture design is valid and can be used to formulate probiotic tablets that possess gastrointestinal tolerance. This study can lead to the development of commercial production of probiotic yeast tablets with gastrointestinal tolerance. Taylor & Francis 2020-12-16 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/30455/1/azhar2020.pdf Mohd Akmal, Azhar and Mimi Sakinah, Abdul Munaim (2020) Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. Drug Development and Industrial Pharmacy. pp. 1-9. ISSN 0363-9045. (Published) https://www.tandfonline.com/loi/iddi20 https://doi.org/10.1080/03639045.2020.1862176 |
| spellingShingle | TP Chemical technology Mohd Akmal, Azhar Mimi Sakinah, Abdul Munaim Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. |
| title | Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. |
| title_full | Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. |
| title_fullStr | Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. |
| title_full_unstemmed | Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. |
| title_short | Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. |
| title_sort | design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex centroid mixture |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/30455/1/azhar2020.pdf |
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